| Full name: scinderin | Alias Symbol: KIAA1905 | ||
| Type: protein-coding gene | Cytoband: 7p21.3 | ||
| Entrez ID: 85477 | HGNC ID: HGNC:21695 | Ensembl Gene: ENSG00000006747 | OMIM ID: 613416 |
| Drug and gene relationship at DGIdb | |||
SCIN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of SCIN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCIN | 85477 | 1552365_at | -3.5938 | 0.0330 | |
| GSE20347 | SCIN | 85477 | 222272_x_at | -0.3317 | 0.0009 | |
| GSE23400 | SCIN | 85477 | 222272_x_at | -0.1600 | 0.0000 | |
| GSE26886 | SCIN | 85477 | 1552365_at | -4.2876 | 0.0000 | |
| GSE29001 | SCIN | 85477 | 222272_x_at | -0.2389 | 0.0056 | |
| GSE38129 | SCIN | 85477 | 222272_x_at | -0.2604 | 0.0101 | |
| GSE45670 | SCIN | 85477 | 1552365_at | -3.4103 | 0.0001 | |
| GSE53622 | SCIN | 85477 | 35926 | -1.8623 | 0.0000 | |
| GSE53624 | SCIN | 85477 | 35926 | -2.2715 | 0.0000 | |
| GSE63941 | SCIN | 85477 | 222272_x_at | -0.0885 | 0.6682 | |
| GSE77861 | SCIN | 85477 | 222272_x_at | -0.2832 | 0.0747 | |
| GSE97050 | SCIN | 85477 | A_23_P157136 | -0.7419 | 0.2401 | |
| SRP007169 | SCIN | 85477 | RNAseq | -3.7593 | 0.0000 | |
| SRP008496 | SCIN | 85477 | RNAseq | -3.4893 | 0.0000 | |
| SRP064894 | SCIN | 85477 | RNAseq | -3.5552 | 0.0000 | |
| SRP133303 | SCIN | 85477 | RNAseq | -2.7686 | 0.0000 | |
| SRP159526 | SCIN | 85477 | RNAseq | -3.0655 | 0.0000 | |
| SRP193095 | SCIN | 85477 | RNAseq | -3.1933 | 0.0000 | |
| SRP219564 | SCIN | 85477 | RNAseq | -3.4480 | 0.0001 | |
| TCGA | SCIN | 85477 | RNAseq | -0.7664 | 0.0063 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by SCIN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCIN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCIN | 85477 | 14 | 2 | 14 | |
| GSE20123 | SCIN | 85477 | 14 | 2 | 14 | |
| GSE43470 | SCIN | 85477 | 5 | 0 | 38 | |
| GSE46452 | SCIN | 85477 | 11 | 1 | 47 | |
| GSE47630 | SCIN | 85477 | 9 | 1 | 30 | |
| GSE54993 | SCIN | 85477 | 0 | 6 | 64 | |
| GSE54994 | SCIN | 85477 | 22 | 1 | 30 | |
| GSE60625 | SCIN | 85477 | 0 | 0 | 11 | |
| GSE74703 | SCIN | 85477 | 5 | 0 | 31 | |
| GSE74704 | SCIN | 85477 | 8 | 2 | 10 | |
| TCGA | SCIN | 85477 | 54 | 7 | 35 |
Total number of gains: 142; Total number of losses: 22; Total Number of normals: 324.
Somatic mutations of SCIN:
Generating mutation plots.
Highly correlated genes for SCIN:
Showing top 20/1385 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCIN | SAMD5 | 0.82774 | 7 | 0 | 7 |
| SCIN | ATP6V1C2 | 0.805333 | 4 | 0 | 4 |
| SCIN | SH3BGRL2 | 0.799255 | 7 | 0 | 7 |
| SCIN | SFTA2 | 0.796406 | 4 | 0 | 4 |
| SCIN | KRT78 | 0.779957 | 7 | 0 | 7 |
| SCIN | FLG-AS1 | 0.773798 | 6 | 0 | 6 |
| SCIN | HCG22 | 0.769497 | 6 | 0 | 6 |
| SCIN | GBP6 | 0.769332 | 4 | 0 | 4 |
| SCIN | C15orf62 | 0.765753 | 7 | 0 | 7 |
| SCIN | CAPN14 | 0.764303 | 6 | 0 | 6 |
| SCIN | PAQR8 | 0.760594 | 7 | 0 | 7 |
| SCIN | SLC10A5 | 0.759345 | 3 | 0 | 3 |
| SCIN | ZNF823 | 0.758537 | 7 | 0 | 7 |
| SCIN | CYSRT1 | 0.755261 | 6 | 0 | 6 |
| SCIN | FAM3D | 0.754644 | 8 | 0 | 7 |
| SCIN | NIPAL1 | 0.753387 | 3 | 0 | 3 |
| SCIN | SPNS2 | 0.752855 | 5 | 0 | 5 |
| SCIN | TMPRSS11B | 0.750703 | 7 | 0 | 7 |
| SCIN | CA13 | 0.750032 | 3 | 0 | 3 |
| SCIN | SASH1 | 0.74708 | 11 | 0 | 11 |
For details and further investigation, click here
