| Full name: ISL LIM homeobox 2 | Alias Symbol: FLJ10160 | ||
| Type: protein-coding gene | Cytoband: 15q24.3 | ||
| Entrez ID: 64843 | HGNC ID: HGNC:18524 | Ensembl Gene: ENSG00000159556 | OMIM ID: 609481 |
| Drug and gene relationship at DGIdb | |||
Expression of ISL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISL2 | 64843 | 232352_at | 0.3033 | 0.5794 | |
| GSE26886 | ISL2 | 64843 | 232352_at | 0.6496 | 0.0001 | |
| GSE45670 | ISL2 | 64843 | 232352_at | 0.1661 | 0.3255 | |
| GSE53622 | ISL2 | 64843 | 97894 | 0.8659 | 0.0000 | |
| GSE53624 | ISL2 | 64843 | 97894 | 1.1697 | 0.0000 | |
| GSE63941 | ISL2 | 64843 | 232352_at | 0.0709 | 0.9236 | |
| GSE77861 | ISL2 | 64843 | 232352_at | 0.0821 | 0.6078 | |
| GSE97050 | ISL2 | 64843 | A_23_P54469 | -0.1823 | 0.4712 | |
| SRP133303 | ISL2 | 64843 | RNAseq | 1.1125 | 0.0007 | |
| SRP159526 | ISL2 | 64843 | RNAseq | 2.1672 | 0.0001 | |
| SRP219564 | ISL2 | 64843 | RNAseq | 0.4462 | 0.4614 | |
| TCGA | ISL2 | 64843 | RNAseq | 0.6974 | 0.0039 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ISL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISL2 | 64843 | 7 | 2 | 21 | |
| GSE20123 | ISL2 | 64843 | 7 | 2 | 21 | |
| GSE43470 | ISL2 | 64843 | 4 | 6 | 33 | |
| GSE46452 | ISL2 | 64843 | 3 | 7 | 49 | |
| GSE47630 | ISL2 | 64843 | 8 | 10 | 22 | |
| GSE54993 | ISL2 | 64843 | 5 | 6 | 59 | |
| GSE54994 | ISL2 | 64843 | 5 | 6 | 42 | |
| GSE60625 | ISL2 | 64843 | 4 | 0 | 7 | |
| GSE74703 | ISL2 | 64843 | 4 | 3 | 29 | |
| GSE74704 | ISL2 | 64843 | 3 | 2 | 15 | |
| TCGA | ISL2 | 64843 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 59; Total Number of normals: 365.
Somatic mutations of ISL2:
Generating mutation plots.
Highly correlated genes for ISL2:
Showing top 20/133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISL2 | ZBTB48 | 0.772766 | 3 | 0 | 3 |
| ISL2 | LINC00302 | 0.72263 | 3 | 0 | 3 |
| ISL2 | SCN9A | 0.697204 | 3 | 0 | 3 |
| ISL2 | TMCC2 | 0.679504 | 3 | 0 | 3 |
| ISL2 | TLR9 | 0.670914 | 3 | 0 | 3 |
| ISL2 | B4GALNT1 | 0.663147 | 4 | 0 | 3 |
| ISL2 | GALNT18 | 0.657764 | 4 | 0 | 3 |
| ISL2 | GTF3C5 | 0.657312 | 3 | 0 | 3 |
| ISL2 | CORT | 0.641603 | 4 | 0 | 4 |
| ISL2 | PRR15 | 0.637346 | 3 | 0 | 3 |
| ISL2 | THAP3 | 0.633489 | 4 | 0 | 3 |
| ISL2 | MSX2 | 0.628766 | 4 | 0 | 4 |
| ISL2 | CHGB | 0.628132 | 4 | 0 | 3 |
| ISL2 | SH3BP4 | 0.616122 | 5 | 0 | 4 |
| ISL2 | SHROOM1 | 0.612568 | 3 | 0 | 3 |
| ISL2 | SEC62 | 0.610905 | 5 | 0 | 5 |
| ISL2 | HOXA11 | 0.609755 | 3 | 0 | 3 |
| ISL2 | S100A4 | 0.609601 | 3 | 0 | 3 |
| ISL2 | WNT9A | 0.609319 | 3 | 0 | 3 |
| ISL2 | MYH9 | 0.605265 | 4 | 0 | 3 |
For details and further investigation, click here
