| Full name: transformer 2 beta homolog | Alias Symbol: Htra2-beta|PPP1R156 | ||
| Type: protein-coding gene | Cytoband: 3q27.2 | ||
| Entrez ID: 6434 | HGNC ID: HGNC:10781 | Ensembl Gene: ENSG00000136527 | OMIM ID: 602719 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRA2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRA2B | 6434 | 200893_at | 0.3149 | 0.2919 | |
| GSE20347 | TRA2B | 6434 | 200893_at | 0.4450 | 0.0002 | |
| GSE23400 | TRA2B | 6434 | 200893_at | 0.4638 | 0.0000 | |
| GSE26886 | TRA2B | 6434 | 200893_at | -0.0568 | 0.7435 | |
| GSE29001 | TRA2B | 6434 | 200893_at | 0.4630 | 0.0275 | |
| GSE38129 | TRA2B | 6434 | 200893_at | 0.4961 | 0.0000 | |
| GSE45670 | TRA2B | 6434 | 200893_at | 0.4024 | 0.0002 | |
| GSE53622 | TRA2B | 6434 | 30395 | 0.3514 | 0.0000 | |
| GSE53624 | TRA2B | 6434 | 30395 | 0.7012 | 0.0000 | |
| GSE63941 | TRA2B | 6434 | 200893_at | 0.9581 | 0.0157 | |
| GSE77861 | TRA2B | 6434 | 200893_at | 0.3158 | 0.0445 | |
| GSE97050 | TRA2B | 6434 | A_33_P3297517 | 0.3338 | 0.3235 | |
| SRP007169 | TRA2B | 6434 | RNAseq | 0.7266 | 0.0673 | |
| SRP008496 | TRA2B | 6434 | RNAseq | 0.8153 | 0.0007 | |
| SRP064894 | TRA2B | 6434 | RNAseq | 0.2439 | 0.0668 | |
| SRP133303 | TRA2B | 6434 | RNAseq | 0.7024 | 0.0000 | |
| SRP159526 | TRA2B | 6434 | RNAseq | 0.6630 | 0.0001 | |
| SRP193095 | TRA2B | 6434 | RNAseq | 0.3317 | 0.0143 | |
| SRP219564 | TRA2B | 6434 | RNAseq | 0.1457 | 0.5406 | |
| TCGA | TRA2B | 6434 | RNAseq | 0.1432 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRA2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRA2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRA2B | 6434 | 25 | 0 | 5 | |
| GSE20123 | TRA2B | 6434 | 25 | 0 | 5 | |
| GSE43470 | TRA2B | 6434 | 23 | 0 | 20 | |
| GSE46452 | TRA2B | 6434 | 19 | 1 | 39 | |
| GSE47630 | TRA2B | 6434 | 27 | 2 | 11 | |
| GSE54993 | TRA2B | 6434 | 1 | 19 | 50 | |
| GSE54994 | TRA2B | 6434 | 40 | 0 | 13 | |
| GSE60625 | TRA2B | 6434 | 0 | 6 | 5 | |
| GSE74703 | TRA2B | 6434 | 20 | 0 | 16 | |
| GSE74704 | TRA2B | 6434 | 17 | 0 | 3 | |
| TCGA | TRA2B | 6434 | 77 | 0 | 19 |
Total number of gains: 274; Total number of losses: 28; Total Number of normals: 186.
Somatic mutations of TRA2B:
Generating mutation plots.
Highly correlated genes for TRA2B:
Showing top 20/1657 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRA2B | TBL1X | 0.800659 | 3 | 0 | 3 |
| TRA2B | PLEKHA3 | 0.799737 | 3 | 0 | 3 |
| TRA2B | PCGF6 | 0.773905 | 4 | 0 | 4 |
| TRA2B | MRPL47 | 0.769498 | 7 | 0 | 7 |
| TRA2B | ACTL6A | 0.757303 | 11 | 0 | 11 |
| TRA2B | BCL7B | 0.742743 | 4 | 0 | 3 |
| TRA2B | FNBP4 | 0.739279 | 3 | 0 | 3 |
| TRA2B | HSPE1 | 0.731277 | 10 | 0 | 10 |
| TRA2B | SRSF2 | 0.727429 | 3 | 0 | 3 |
| TRA2B | LRRC34 | 0.724326 | 3 | 0 | 3 |
| TRA2B | PYCR2 | 0.724288 | 3 | 0 | 3 |
| TRA2B | SDHB | 0.723285 | 3 | 0 | 3 |
| TRA2B | FBXO5 | 0.718767 | 10 | 0 | 10 |
| TRA2B | ZNF496 | 0.71872 | 4 | 0 | 3 |
| TRA2B | BOLA3 | 0.717146 | 6 | 0 | 6 |
| TRA2B | U2SURP | 0.716247 | 9 | 0 | 8 |
| TRA2B | HSPD1 | 0.714672 | 11 | 0 | 11 |
| TRA2B | LRRC58 | 0.714446 | 5 | 0 | 4 |
| TRA2B | METAP1D | 0.714424 | 4 | 0 | 4 |
| TRA2B | MCM6 | 0.714411 | 10 | 0 | 9 |
For details and further investigation, click here
