| Full name: 5'-3' exoribonuclease 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p11.22 | ||
| Entrez ID: 22803 | HGNC ID: HGNC:12836 | Ensembl Gene: ENSG00000088930 | OMIM ID: 608851 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of XRN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRN2 | 22803 | 223002_s_at | 0.5990 | 0.2059 | |
| GSE26886 | XRN2 | 22803 | 223002_s_at | 0.3666 | 0.0358 | |
| GSE45670 | XRN2 | 22803 | 223002_s_at | 0.4018 | 0.0211 | |
| GSE53622 | XRN2 | 22803 | 22164 | 0.7653 | 0.0000 | |
| GSE53624 | XRN2 | 22803 | 22164 | 0.8028 | 0.0000 | |
| GSE63941 | XRN2 | 22803 | 233878_s_at | 0.9116 | 0.0101 | |
| GSE77861 | XRN2 | 22803 | 223002_s_at | 0.8898 | 0.0101 | |
| GSE97050 | XRN2 | 22803 | A_23_P166135 | 0.6607 | 0.3482 | |
| SRP007169 | XRN2 | 22803 | RNAseq | 1.1660 | 0.0003 | |
| SRP008496 | XRN2 | 22803 | RNAseq | 1.0934 | 0.0000 | |
| SRP064894 | XRN2 | 22803 | RNAseq | 0.5916 | 0.0026 | |
| SRP133303 | XRN2 | 22803 | RNAseq | 0.6642 | 0.0000 | |
| SRP159526 | XRN2 | 22803 | RNAseq | 0.8019 | 0.0003 | |
| SRP193095 | XRN2 | 22803 | RNAseq | 0.5109 | 0.0000 | |
| SRP219564 | XRN2 | 22803 | RNAseq | 0.4983 | 0.0551 | |
| TCGA | XRN2 | 22803 | RNAseq | 0.1108 | 0.0127 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by XRN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRN2 | 22803 | 13 | 1 | 16 | |
| GSE20123 | XRN2 | 22803 | 13 | 1 | 16 | |
| GSE43470 | XRN2 | 22803 | 11 | 1 | 31 | |
| GSE46452 | XRN2 | 22803 | 27 | 1 | 31 | |
| GSE47630 | XRN2 | 22803 | 17 | 4 | 19 | |
| GSE54993 | XRN2 | 22803 | 0 | 15 | 55 | |
| GSE54994 | XRN2 | 22803 | 27 | 2 | 24 | |
| GSE60625 | XRN2 | 22803 | 0 | 0 | 11 | |
| GSE74703 | XRN2 | 22803 | 8 | 1 | 27 | |
| GSE74704 | XRN2 | 22803 | 7 | 1 | 12 | |
| TCGA | XRN2 | 22803 | 44 | 10 | 42 |
Total number of gains: 167; Total number of losses: 37; Total Number of normals: 284.
Somatic mutations of XRN2:
Generating mutation plots.
Highly correlated genes for XRN2:
Showing top 20/896 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRN2 | APMAP | 0.772881 | 6 | 0 | 5 |
| XRN2 | AAR2 | 0.740722 | 3 | 0 | 3 |
| XRN2 | ZNF622 | 0.728159 | 3 | 0 | 3 |
| XRN2 | POLR3F | 0.710746 | 6 | 0 | 5 |
| XRN2 | ESF1 | 0.702834 | 3 | 0 | 3 |
| XRN2 | USP42 | 0.690024 | 4 | 0 | 4 |
| XRN2 | HSP90AA1 | 0.689526 | 4 | 0 | 4 |
| XRN2 | SPRED1 | 0.689426 | 4 | 0 | 3 |
| XRN2 | SNRPB | 0.686567 | 7 | 0 | 7 |
| XRN2 | NIF3L1 | 0.686455 | 4 | 0 | 4 |
| XRN2 | C4orf46 | 0.683421 | 3 | 0 | 3 |
| XRN2 | FEN1 | 0.682754 | 3 | 0 | 3 |
| XRN2 | ARL6IP6 | 0.681679 | 5 | 0 | 5 |
| XRN2 | VBP1 | 0.681272 | 4 | 0 | 4 |
| XRN2 | DSN1 | 0.678457 | 5 | 0 | 5 |
| XRN2 | CBX3 | 0.677711 | 5 | 0 | 5 |
| XRN2 | ZNF146 | 0.677616 | 4 | 0 | 3 |
| XRN2 | NOP56 | 0.675122 | 3 | 0 | 3 |
| XRN2 | CDC25B | 0.673434 | 5 | 0 | 4 |
| XRN2 | ECT2 | 0.673274 | 5 | 0 | 5 |
For details and further investigation, click here
