| Full name: serpin family A member 3 | Alias Symbol: ACT | ||
| Type: protein-coding gene | Cytoband: 14q32.13 | ||
| Entrez ID: 12 | HGNC ID: HGNC:16 | Ensembl Gene: ENSG00000196136 | OMIM ID: 107280 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINA3 | 12 | 202376_at | -0.1292 | 0.9299 | |
| GSE20347 | SERPINA3 | 12 | 202376_at | 0.7639 | 0.0509 | |
| GSE23400 | SERPINA3 | 12 | 202376_at | -0.0708 | 0.5711 | |
| GSE26886 | SERPINA3 | 12 | 202376_at | 1.9930 | 0.0247 | |
| GSE29001 | SERPINA3 | 12 | 202376_at | 0.5749 | 0.1075 | |
| GSE38129 | SERPINA3 | 12 | 202376_at | 0.1751 | 0.7129 | |
| GSE45670 | SERPINA3 | 12 | 202376_at | -0.9833 | 0.1636 | |
| GSE53622 | SERPINA3 | 12 | 8166 | -0.8477 | 0.0040 | |
| GSE53624 | SERPINA3 | 12 | 8166 | -0.5134 | 0.0574 | |
| GSE63941 | SERPINA3 | 12 | 202376_at | -1.3122 | 0.2737 | |
| GSE77861 | SERPINA3 | 12 | 202376_at | 0.7391 | 0.2188 | |
| GSE97050 | SERPINA3 | 12 | A_23_P162918 | 0.6559 | 0.4202 | |
| SRP064894 | SERPINA3 | 12 | RNAseq | 0.5442 | 0.3385 | |
| SRP133303 | SERPINA3 | 12 | RNAseq | 2.4505 | 0.0147 | |
| SRP193095 | SERPINA3 | 12 | RNAseq | 1.7146 | 0.0113 | |
| TCGA | SERPINA3 | 12 | RNAseq | -0.4527 | 0.1301 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SERPINA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINA3 | 12 | 10 | 4 | 16 | |
| GSE20123 | SERPINA3 | 12 | 10 | 3 | 17 | |
| GSE43470 | SERPINA3 | 12 | 7 | 3 | 33 | |
| GSE46452 | SERPINA3 | 12 | 16 | 3 | 40 | |
| GSE47630 | SERPINA3 | 12 | 11 | 8 | 21 | |
| GSE54993 | SERPINA3 | 12 | 3 | 8 | 59 | |
| GSE54994 | SERPINA3 | 12 | 21 | 4 | 28 | |
| GSE60625 | SERPINA3 | 12 | 0 | 2 | 9 | |
| GSE74703 | SERPINA3 | 12 | 6 | 3 | 27 | |
| GSE74704 | SERPINA3 | 12 | 6 | 3 | 11 | |
| TCGA | SERPINA3 | 12 | 30 | 20 | 46 |
Total number of gains: 120; Total number of losses: 61; Total Number of normals: 307.
Somatic mutations of SERPINA3:
Generating mutation plots.
Highly correlated genes for SERPINA3:
Showing top 20/369 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINA3 | INVS | 0.723529 | 3 | 0 | 3 |
| SERPINA3 | LINC01361 | 0.697947 | 3 | 0 | 3 |
| SERPINA3 | TSN | 0.695607 | 3 | 0 | 3 |
| SERPINA3 | RUNX1-IT1 | 0.690755 | 3 | 0 | 3 |
| SERPINA3 | KDM6B | 0.680734 | 3 | 0 | 3 |
| SERPINA3 | TGFB1 | 0.680308 | 3 | 0 | 3 |
| SERPINA3 | TWIST2 | 0.678676 | 3 | 0 | 3 |
| SERPINA3 | CATSPER1 | 0.670897 | 3 | 0 | 3 |
| SERPINA3 | TNFRSF10B | 0.670436 | 3 | 0 | 3 |
| SERPINA3 | SOX5 | 0.66142 | 3 | 0 | 3 |
| SERPINA3 | IRF9 | 0.659772 | 3 | 0 | 3 |
| SERPINA3 | LARP1 | 0.659211 | 3 | 0 | 3 |
| SERPINA3 | CERCAM | 0.657928 | 4 | 0 | 3 |
| SERPINA3 | NKX2-2 | 0.657368 | 3 | 0 | 3 |
| SERPINA3 | GPR3 | 0.656719 | 3 | 0 | 3 |
| SERPINA3 | BCL7A | 0.655572 | 3 | 0 | 3 |
| SERPINA3 | SPOCK1 | 0.655191 | 4 | 0 | 4 |
| SERPINA3 | PPFIA1 | 0.652634 | 4 | 0 | 4 |
| SERPINA3 | FADD | 0.65113 | 4 | 0 | 4 |
| SERPINA3 | NOL11 | 0.647845 | 3 | 0 | 3 |
For details and further investigation, click here
