| Full name: serpin family B member 4 | Alias Symbol: PI11|LEUPIN|SCCA-2|SCCA1 | ||
| Type: protein-coding gene | Cytoband: 18q21.33 | ||
| Entrez ID: 6318 | HGNC ID: HGNC:10570 | Ensembl Gene: ENSG00000206073 | OMIM ID: 600518 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SERPINB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB4 | 6318 | 211906_s_at | -2.2295 | 0.5376 | |
| GSE20347 | SERPINB4 | 6318 | 211906_s_at | -3.2481 | 0.0000 | |
| GSE23400 | SERPINB4 | 6318 | 211906_s_at | -2.4282 | 0.0000 | |
| GSE26886 | SERPINB4 | 6318 | 211906_s_at | -6.2239 | 0.0000 | |
| GSE29001 | SERPINB4 | 6318 | 211906_s_at | -3.4173 | 0.0001 | |
| GSE38129 | SERPINB4 | 6318 | 211906_s_at | -1.5870 | 0.0560 | |
| GSE45670 | SERPINB4 | 6318 | 211906_s_at | 0.7393 | 0.1994 | |
| GSE53622 | SERPINB4 | 6318 | 138320 | -2.3796 | 0.0000 | |
| GSE53624 | SERPINB4 | 6318 | 138320 | -2.9135 | 0.0000 | |
| GSE63941 | SERPINB4 | 6318 | 211906_s_at | 1.1108 | 0.4781 | |
| GSE77861 | SERPINB4 | 6318 | 211906_s_at | -0.7618 | 0.1776 | |
| GSE97050 | SERPINB4 | 6318 | A_23_P502413 | -0.9637 | 0.5920 | |
| SRP007169 | SERPINB4 | 6318 | RNAseq | -5.5544 | 0.0000 | |
| SRP008496 | SERPINB4 | 6318 | RNAseq | -3.7374 | 0.0002 | |
| SRP064894 | SERPINB4 | 6318 | RNAseq | -1.7487 | 0.0127 | |
| SRP133303 | SERPINB4 | 6318 | RNAseq | -1.1479 | 0.0569 | |
| SRP219564 | SERPINB4 | 6318 | RNAseq | -1.9619 | 0.1257 | |
| TCGA | SERPINB4 | 6318 | RNAseq | 1.2953 | 0.0066 |
Upregulated datasets: 1; Downregulated datasets: 9.
Survival by SERPINB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB4 | 6318 | 1 | 9 | 20 | |
| GSE20123 | SERPINB4 | 6318 | 1 | 9 | 20 | |
| GSE43470 | SERPINB4 | 6318 | 0 | 7 | 36 | |
| GSE46452 | SERPINB4 | 6318 | 1 | 26 | 32 | |
| GSE47630 | SERPINB4 | 6318 | 5 | 21 | 14 | |
| GSE54993 | SERPINB4 | 6318 | 9 | 0 | 61 | |
| GSE54994 | SERPINB4 | 6318 | 1 | 18 | 34 | |
| GSE60625 | SERPINB4 | 6318 | 0 | 4 | 7 | |
| GSE74703 | SERPINB4 | 6318 | 0 | 7 | 29 | |
| GSE74704 | SERPINB4 | 6318 | 1 | 6 | 13 | |
| TCGA | SERPINB4 | 6318 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB4:
Generating mutation plots.
Highly correlated genes for SERPINB4:
Showing top 20/1271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB4 | SERPINB3 | 0.87642 | 11 | 0 | 11 |
| SERPINB4 | CERS3 | 0.770557 | 6 | 0 | 6 |
| SERPINB4 | EPGN | 0.759494 | 3 | 0 | 3 |
| SERPINB4 | PGLYRP3 | 0.756986 | 4 | 0 | 4 |
| SERPINB4 | KLK13 | 0.750804 | 12 | 0 | 11 |
| SERPINB4 | MPZL3 | 0.748527 | 7 | 0 | 7 |
| SERPINB4 | ENDOU | 0.747525 | 10 | 0 | 10 |
| SERPINB4 | C5orf66-AS1 | 0.746516 | 4 | 0 | 4 |
| SERPINB4 | FLG | 0.746441 | 10 | 0 | 10 |
| SERPINB4 | BNIPL | 0.742672 | 6 | 0 | 5 |
| SERPINB4 | SERPINB1 | 0.738457 | 12 | 0 | 11 |
| SERPINB4 | SPAG17 | 0.737822 | 4 | 0 | 4 |
| SERPINB4 | NIPAL1 | 0.737637 | 3 | 0 | 3 |
| SERPINB4 | SCEL | 0.736323 | 12 | 0 | 11 |
| SERPINB4 | IL18 | 0.736306 | 10 | 0 | 10 |
| SERPINB4 | CRABP2 | 0.736085 | 10 | 0 | 9 |
| SERPINB4 | TMPRSS11D | 0.733887 | 12 | 0 | 11 |
| SERPINB4 | TMPRSS11E | 0.732686 | 12 | 0 | 10 |
| SERPINB4 | HOPX | 0.732453 | 11 | 0 | 10 |
| SERPINB4 | CXCR2 | 0.729071 | 9 | 0 | 9 |
For details and further investigation, click here
