| Full name: surfactant protein D | Alias Symbol: SP-D|COLEC7 | ||
| Type: protein-coding gene | Cytoband: 10q22.3 | ||
| Entrez ID: 6441 | HGNC ID: HGNC:10803 | Ensembl Gene: ENSG00000133661 | OMIM ID: 178635 |
| Drug and gene relationship at DGIdb | |||
Expression of SFTPD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SFTPD | 6441 | 214199_at | 0.4443 | 0.4857 | |
| GSE20347 | SFTPD | 6441 | 214199_at | -0.2017 | 0.0553 | |
| GSE23400 | SFTPD | 6441 | 214199_at | -0.1422 | 0.0000 | |
| GSE26886 | SFTPD | 6441 | 214199_at | -0.0551 | 0.7517 | |
| GSE29001 | SFTPD | 6441 | 214199_at | -0.3026 | 0.2102 | |
| GSE38129 | SFTPD | 6441 | 214199_at | -0.2139 | 0.0407 | |
| GSE45670 | SFTPD | 6441 | 214199_at | 0.0529 | 0.8323 | |
| GSE53622 | SFTPD | 6441 | 29937 | -0.3960 | 0.0000 | |
| GSE53624 | SFTPD | 6441 | 29937 | -0.6830 | 0.0000 | |
| GSE63941 | SFTPD | 6441 | 214199_at | 0.3432 | 0.1657 | |
| GSE77861 | SFTPD | 6441 | 214199_at | -0.2002 | 0.0401 | |
| GSE97050 | SFTPD | 6441 | A_32_P107617 | 0.0261 | 0.9369 | |
| SRP064894 | SFTPD | 6441 | RNAseq | -0.5634 | 0.1910 | |
| SRP133303 | SFTPD | 6441 | RNAseq | -0.9079 | 0.0067 | |
| SRP159526 | SFTPD | 6441 | RNAseq | -0.9389 | 0.0628 | |
| SRP219564 | SFTPD | 6441 | RNAseq | 0.1983 | 0.6993 | |
| TCGA | SFTPD | 6441 | RNAseq | -0.2773 | 0.4766 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SFTPD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SFTPD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SFTPD | 6441 | 2 | 4 | 24 | |
| GSE20123 | SFTPD | 6441 | 2 | 3 | 25 | |
| GSE43470 | SFTPD | 6441 | 1 | 7 | 35 | |
| GSE46452 | SFTPD | 6441 | 0 | 11 | 48 | |
| GSE47630 | SFTPD | 6441 | 2 | 14 | 24 | |
| GSE54993 | SFTPD | 6441 | 7 | 0 | 63 | |
| GSE54994 | SFTPD | 6441 | 1 | 12 | 40 | |
| GSE60625 | SFTPD | 6441 | 0 | 0 | 11 | |
| GSE74703 | SFTPD | 6441 | 1 | 4 | 31 | |
| GSE74704 | SFTPD | 6441 | 1 | 1 | 18 | |
| TCGA | SFTPD | 6441 | 10 | 24 | 62 |
Total number of gains: 27; Total number of losses: 80; Total Number of normals: 381.
Somatic mutations of SFTPD:
Generating mutation plots.
Highly correlated genes for SFTPD:
Showing top 20/80 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SFTPD | TMEM52 | 0.774526 | 3 | 0 | 3 |
| SFTPD | FOLR3 | 0.715332 | 3 | 0 | 3 |
| SFTPD | ANKRD33B | 0.707595 | 3 | 0 | 3 |
| SFTPD | DCAF15 | 0.683082 | 3 | 0 | 3 |
| SFTPD | INHBC | 0.682646 | 3 | 0 | 3 |
| SFTPD | NR2E1 | 0.681242 | 4 | 0 | 3 |
| SFTPD | SLC22A18AS | 0.664607 | 3 | 0 | 3 |
| SFTPD | ZNF519 | 0.658905 | 3 | 0 | 3 |
| SFTPD | NCAN | 0.653516 | 5 | 0 | 3 |
| SFTPD | ACRV1 | 0.65324 | 5 | 0 | 4 |
| SFTPD | FGFR4 | 0.649533 | 3 | 0 | 3 |
| SFTPD | TMPRSS15 | 0.64898 | 4 | 0 | 3 |
| SFTPD | CELF5 | 0.647645 | 4 | 0 | 3 |
| SFTPD | SEC14L3 | 0.645609 | 4 | 0 | 3 |
| SFTPD | PSPN | 0.625323 | 4 | 0 | 3 |
| SFTPD | SORCS2 | 0.624788 | 3 | 0 | 3 |
| SFTPD | C14orf180 | 0.620456 | 4 | 0 | 3 |
| SFTPD | CPN1 | 0.619217 | 5 | 0 | 3 |
| SFTPD | PLCH2 | 0.616967 | 5 | 0 | 4 |
| SFTPD | ZFHX2 | 0.616213 | 4 | 0 | 3 |
For details and further investigation, click here
