C1S

 

Full name: complement C1s Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 716 HGNC ID: HGNC:1247 Ensembl Gene: ENSG00000182326 OMIM ID: 120580
Drug and gene relationship at DGIdb

 

C1S involved pathways:

KEGG pathway Description View
hsa04610Complement and coagulation cascades
hsa05133Pertussis
hsa05150Staphylococcus aureus infection

 

Expression of C1S:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C1S 716 208747_s_at 0.2487 0.7683
GSE20347 C1S 716 208747_s_at 1.8537 0.0000
GSE23400 C1S 716 208747_s_at 0.8645 0.0000
GSE26886 C1S 716 208747_s_at 1.9759 0.0031
GSE29001 C1S 716 208747_s_at 1.6007 0.0067
GSE38129 C1S 716 208747_s_at 1.0778 0.0054
GSE45670 C1S 716 208747_s_at -0.6789 0.1727
GSE53622 C1S 716 50698 0.5231 0.0002
GSE53624 C1S 716 50698 0.8724 0.0000
GSE63941 C1S 716 208747_s_at -5.8211 0.0009
GSE77861 C1S 716 208747_s_at 2.3793 0.0057
GSE97050 C1S 716 A_23_P2492 0.4469 0.2467
SRP007169 C1S 716 RNAseq 2.3460 0.0000
SRP008496 C1S 716 RNAseq 2.9002 0.0000
SRP064894 C1S 716 RNAseq 0.6686 0.0340
SRP133303 C1S 716 RNAseq 0.5948 0.0867
SRP159526 C1S 716 RNAseq 0.6069 0.0642
SRP193095 C1S 716 RNAseq 2.2085 0.0000
SRP219564 C1S 716 RNAseq 1.3357 0.0498
TCGA C1S 716 RNAseq 0.0970 0.3016

Upregulated datasets: 9; Downregulated datasets: 1.  

 

Survival by C1S expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C1S:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C1S 716 8 3 19
GSE20123 C1S 716 8 3 19
GSE43470 C1S 716 8 3 32
GSE46452 C1S 716 10 1 48
GSE47630 C1S 716 12 2 26
GSE54993 C1S 716 1 10 59
GSE54994 C1S 716 10 2 41
GSE60625 C1S 716 0 1 10
GSE74703 C1S 716 7 2 27
GSE74704 C1S 716 5 2 13
TCGA C1S 716 40 6 50

Total number of gains: 109; Total number of losses: 35; Total Number of normals: 344.  

 

Somatic mutations of C1S:

 

Generating mutation plots.

 

Highly correlated genes for C1S:

 

Showing top 20/1219 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C1SC1R0.89745613013
C1SDRAM10.74567313013
C1SSERPING10.74104513012
C1SMMP20.73362411010
C1SCD140.72413612012
C1SVCAM10.72235411011
C1SFSTL10.71817113012
C1SLHFPL20.71541613013
C1SCOL6A30.71541113012
C1SCTSK0.71484313013
C1SSH2B30.71206212012
C1SBICC10.711148909
C1SIGFBP70.71084413012
C1SLRRC8C0.710696303
C1SSH3RF30.710215505
C1SALKBH60.707916303
C1SVCAN0.70692913012
C1SLUM0.70414713013
C1SNAPB0.70349303
C1SPLXND10.70183912012

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