| Full name: transforming acidic coiled-coil containing protein 3 | Alias Symbol: ERIC1 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 10460 | HGNC ID: HGNC:11524 | Ensembl Gene: ENSG00000013810 | OMIM ID: 605303 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TACC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TACC3 | 10460 | 218308_at | 1.3607 | 0.0240 | |
| GSE20347 | TACC3 | 10460 | 218308_at | 0.7950 | 0.0000 | |
| GSE23400 | TACC3 | 10460 | 218308_at | 0.6077 | 0.0000 | |
| GSE26886 | TACC3 | 10460 | 218308_at | 0.4991 | 0.0396 | |
| GSE29001 | TACC3 | 10460 | 218308_at | 1.2904 | 0.0004 | |
| GSE38129 | TACC3 | 10460 | 218308_at | 1.1011 | 0.0000 | |
| GSE45670 | TACC3 | 10460 | 218308_at | 0.9337 | 0.0000 | |
| GSE53622 | TACC3 | 10460 | 40871 | 1.2190 | 0.0000 | |
| GSE53624 | TACC3 | 10460 | 40871 | 1.4545 | 0.0000 | |
| GSE63941 | TACC3 | 10460 | 218308_at | 1.6552 | 0.0079 | |
| GSE77861 | TACC3 | 10460 | 218308_at | 0.5922 | 0.0635 | |
| GSE97050 | TACC3 | 10460 | A_23_P212844 | 1.2174 | 0.1883 | |
| SRP007169 | TACC3 | 10460 | RNAseq | 2.2324 | 0.0002 | |
| SRP008496 | TACC3 | 10460 | RNAseq | 1.9444 | 0.0001 | |
| SRP064894 | TACC3 | 10460 | RNAseq | 1.7451 | 0.0000 | |
| SRP133303 | TACC3 | 10460 | RNAseq | 0.9521 | 0.0000 | |
| SRP159526 | TACC3 | 10460 | RNAseq | 1.3887 | 0.0071 | |
| SRP193095 | TACC3 | 10460 | RNAseq | 0.6620 | 0.0000 | |
| SRP219564 | TACC3 | 10460 | RNAseq | 1.3040 | 0.0169 | |
| TCGA | TACC3 | 10460 | RNAseq | 0.7154 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by TACC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TACC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TACC3 | 10460 | 0 | 16 | 14 | |
| GSE20123 | TACC3 | 10460 | 0 | 16 | 14 | |
| GSE43470 | TACC3 | 10460 | 1 | 16 | 26 | |
| GSE46452 | TACC3 | 10460 | 1 | 36 | 22 | |
| GSE47630 | TACC3 | 10460 | 2 | 19 | 19 | |
| GSE54993 | TACC3 | 10460 | 11 | 0 | 59 | |
| GSE54994 | TACC3 | 10460 | 3 | 12 | 38 | |
| GSE60625 | TACC3 | 10460 | 0 | 0 | 11 | |
| GSE74703 | TACC3 | 10460 | 1 | 12 | 23 | |
| GSE74704 | TACC3 | 10460 | 0 | 8 | 12 | |
| TCGA | TACC3 | 10460 | 9 | 47 | 40 |
Total number of gains: 28; Total number of losses: 182; Total Number of normals: 278.
Somatic mutations of TACC3:
Generating mutation plots.
Highly correlated genes for TACC3:
Showing top 20/1756 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TACC3 | CENPF | 0.836988 | 12 | 0 | 12 |
| TACC3 | CCNB2 | 0.827139 | 11 | 0 | 11 |
| TACC3 | KIF4A | 0.824927 | 11 | 0 | 11 |
| TACC3 | NEK2 | 0.820103 | 12 | 0 | 12 |
| TACC3 | UBE2C | 0.815978 | 13 | 0 | 12 |
| TACC3 | NUF2 | 0.815686 | 8 | 0 | 8 |
| TACC3 | TOP2A | 0.815413 | 12 | 0 | 12 |
| TACC3 | UBE2T | 0.808945 | 8 | 0 | 8 |
| TACC3 | TRIP13 | 0.808678 | 12 | 0 | 12 |
| TACC3 | ASPM | 0.807278 | 12 | 0 | 12 |
| TACC3 | FANCI | 0.806302 | 12 | 0 | 12 |
| TACC3 | KIF2C | 0.80418 | 12 | 0 | 12 |
| TACC3 | CEP55 | 0.803149 | 12 | 0 | 12 |
| TACC3 | AURKB | 0.802665 | 13 | 0 | 12 |
| TACC3 | BUB1B | 0.801367 | 9 | 0 | 9 |
| TACC3 | PRC1 | 0.799181 | 12 | 0 | 12 |
| TACC3 | BUB1 | 0.798016 | 10 | 0 | 10 |
| TACC3 | CDKN3 | 0.796018 | 12 | 0 | 12 |
| TACC3 | TPX2 | 0.795496 | 13 | 0 | 12 |
| TACC3 | CDCA2 | 0.795356 | 6 | 0 | 6 |
For details and further investigation, click here
