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Multi-Omics Database of ESCC

 

SH3GLB2

 

Full name: SH3 domain containing GRB2 like, endophilin B2 Alias Symbol: KIAA1848
Type: protein-coding gene Cytoband: 9q34.11
Entrez ID: 56904 HGNC ID: HGNC:10834 Ensembl Gene: ENSG00000148341 OMIM ID: 609288
Drug and gene relationship at DGIdb

 

Expression of SH3GLB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SH3GLB2 56904 218813_s_at -1.2430 0.0569
GSE20347 SH3GLB2 56904 218813_s_at -1.8528 0.0000
GSE23400 SH3GLB2 56904 218813_s_at -1.2459 0.0000
GSE26886 SH3GLB2 56904 224432_at -0.3469 0.0076
GSE29001 SH3GLB2 56904 218813_s_at -0.7742 0.0001
GSE38129 SH3GLB2 56904 218813_s_at -1.3642 0.0000
GSE45670 SH3GLB2 56904 224432_at 0.0336 0.8076
GSE53622 SH3GLB2 56904 1274 -1.3179 0.0000
GSE53624 SH3GLB2 56904 1274 -1.4845 0.0000
GSE63941 SH3GLB2 56904 224432_at 0.7297 0.0150
GSE77861 SH3GLB2 56904 218813_s_at -0.6709 0.0218
GSE97050 SH3GLB2 56904 A_24_P386334 -0.6905 0.1260
SRP007169 SH3GLB2 56904 RNAseq -2.4773 0.0000
SRP008496 SH3GLB2 56904 RNAseq -2.3739 0.0000
SRP064894 SH3GLB2 56904 RNAseq -1.1685 0.0000
SRP133303 SH3GLB2 56904 RNAseq -1.5192 0.0000
SRP159526 SH3GLB2 56904 RNAseq -1.3954 0.0000
SRP193095 SH3GLB2 56904 RNAseq -1.2128 0.0000
SRP219564 SH3GLB2 56904 RNAseq -1.3433 0.0029
TCGA SH3GLB2 56904 RNAseq -0.2241 0.0001

Upregulated datasets: 0; Downregulated datasets: 12.  

 

Survival by SH3GLB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SH3GLB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SH3GLB2 56904 6 9 15
GSE20123 SH3GLB2 56904 6 9 15
GSE43470 SH3GLB2 56904 5 8 30
GSE46452 SH3GLB2 56904 6 13 40
GSE47630 SH3GLB2 56904 3 16 21
GSE54993 SH3GLB2 56904 3 3 64
GSE54994 SH3GLB2 56904 11 8 34
GSE60625 SH3GLB2 56904 0 0 11
GSE74703 SH3GLB2 56904 5 6 25
GSE74704 SH3GLB2 56904 3 7 10
TCGA SH3GLB2 56904 27 24 45

Total number of gains: 75; Total number of losses: 103; Total Number of normals: 310.  

 

Somatic mutations of SH3GLB2:

 

Generating mutation plots.

 

Highly correlated genes for SH3GLB2:

 

Showing top 20/1210 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SH3GLB2UPK1A0.78252610010
SH3GLB2PSCA0.778036707
SH3GLB2CRISP30.76071111011
SH3GLB2CAPN50.75964310010
SH3GLB2SLC35C10.756971008
SH3GLB2ENDOU0.75479211010
SH3GLB2SLC16A60.75457410010
SH3GLB2SCNN1B0.74600111010
SH3GLB2SLC7A40.743996808
SH3GLB2KLHL100.743925303
SH3GLB2YPEL30.742804505
SH3GLB2CLIC30.740011908
SH3GLB2IL36A0.7387131009
SH3GLB2ALS2CL0.73595912011
SH3GLB2SMC5-AS10.735681303
SH3GLB2ANXA90.73551311010
SH3GLB2SLC37A10.7334051009
SH3GLB2MYZAP0.732812303
SH3GLB2CYP2C90.732476909
SH3GLB2CEACAM70.731519909

For details and further investigation, click here