| Full name: SIL1 nucleotide exchange factor | Alias Symbol: BAP|ULG5 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 64374 | HGNC ID: HGNC:24624 | Ensembl Gene: ENSG00000120725 | OMIM ID: 608005 |
| Drug and gene relationship at DGIdb | |||
Expression of SIL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIL1 | 64374 | 218436_at | 0.1763 | 0.7283 | |
| GSE20347 | SIL1 | 64374 | 218436_at | 0.0479 | 0.8419 | |
| GSE23400 | SIL1 | 64374 | 218436_at | 0.0896 | 0.2147 | |
| GSE26886 | SIL1 | 64374 | 218436_at | 0.7792 | 0.0003 | |
| GSE29001 | SIL1 | 64374 | 218436_at | 0.0589 | 0.8026 | |
| GSE38129 | SIL1 | 64374 | 218436_at | -0.0004 | 0.9983 | |
| GSE45670 | SIL1 | 64374 | 218436_at | 0.3017 | 0.0232 | |
| GSE53622 | SIL1 | 64374 | 15471 | 0.0056 | 0.9600 | |
| GSE53624 | SIL1 | 64374 | 15471 | 0.5168 | 0.0000 | |
| GSE63941 | SIL1 | 64374 | 218436_at | -1.0587 | 0.0058 | |
| GSE77861 | SIL1 | 64374 | 218436_at | -0.0902 | 0.6802 | |
| GSE97050 | SIL1 | 64374 | A_33_P3341586 | -0.0287 | 0.9215 | |
| SRP007169 | SIL1 | 64374 | RNAseq | 0.2988 | 0.6483 | |
| SRP008496 | SIL1 | 64374 | RNAseq | 0.2228 | 0.6029 | |
| SRP064894 | SIL1 | 64374 | RNAseq | 0.5007 | 0.0666 | |
| SRP133303 | SIL1 | 64374 | RNAseq | 0.8280 | 0.0068 | |
| SRP159526 | SIL1 | 64374 | RNAseq | 0.2891 | 0.4664 | |
| SRP193095 | SIL1 | 64374 | RNAseq | 0.0675 | 0.6217 | |
| SRP219564 | SIL1 | 64374 | RNAseq | 0.4684 | 0.2318 | |
| TCGA | SIL1 | 64374 | RNAseq | -0.1988 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SIL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIL1 | 64374 | 3 | 11 | 16 | |
| GSE20123 | SIL1 | 64374 | 4 | 11 | 15 | |
| GSE43470 | SIL1 | 64374 | 4 | 7 | 32 | |
| GSE46452 | SIL1 | 64374 | 0 | 27 | 32 | |
| GSE47630 | SIL1 | 64374 | 0 | 21 | 19 | |
| GSE54993 | SIL1 | 64374 | 9 | 1 | 60 | |
| GSE54994 | SIL1 | 64374 | 3 | 13 | 37 | |
| GSE60625 | SIL1 | 64374 | 0 | 0 | 11 | |
| GSE74703 | SIL1 | 64374 | 3 | 5 | 28 | |
| GSE74704 | SIL1 | 64374 | 3 | 5 | 12 | |
| TCGA | SIL1 | 64374 | 4 | 37 | 55 |
Total number of gains: 33; Total number of losses: 138; Total Number of normals: 317.
Somatic mutations of SIL1:
Generating mutation plots.
Highly correlated genes for SIL1:
Showing top 20/116 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIL1 | SOHLH1 | 0.711518 | 3 | 0 | 3 |
| SIL1 | SHC3 | 0.708821 | 3 | 0 | 3 |
| SIL1 | WDR83 | 0.701168 | 3 | 0 | 3 |
| SIL1 | BTBD8 | 0.69364 | 3 | 0 | 3 |
| SIL1 | C4BPA | 0.681718 | 3 | 0 | 3 |
| SIL1 | S100A7A | 0.678659 | 3 | 0 | 3 |
| SIL1 | ETFB | 0.673135 | 3 | 0 | 3 |
| SIL1 | GNL1 | 0.658859 | 5 | 0 | 4 |
| SIL1 | EYS | 0.64552 | 4 | 0 | 3 |
| SIL1 | MEP1A | 0.634398 | 4 | 0 | 3 |
| SIL1 | EVX1 | 0.634142 | 4 | 0 | 3 |
| SIL1 | DSPP | 0.632302 | 4 | 0 | 3 |
| SIL1 | ANXA2R | 0.631679 | 3 | 0 | 3 |
| SIL1 | MAGEL2 | 0.631242 | 4 | 0 | 3 |
| SIL1 | CSGALNACT2 | 0.627485 | 4 | 0 | 4 |
| SIL1 | CDH4 | 0.626369 | 3 | 0 | 3 |
| SIL1 | LONP1 | 0.624903 | 4 | 0 | 3 |
| SIL1 | HTRA4 | 0.624757 | 4 | 0 | 3 |
| SIL1 | CDC42EP2 | 0.619854 | 4 | 0 | 3 |
| SIL1 | EDNRA | 0.616539 | 3 | 0 | 3 |
For details and further investigation, click here
