| Full name: sirtuin 1 | Alias Symbol: SIR2L1 | ||
| Type: protein-coding gene | Cytoband: 10q21.3 | ||
| Entrez ID: 23411 | HGNC ID: HGNC:14929 | Ensembl Gene: ENSG00000096717 | OMIM ID: 604479 |
| Drug and gene relationship at DGIdb | |||
SIRT1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04211 | Longevity regulating pathway - mammal | |
| hsa04213 | Longevity regulating pathway - multiple species | |
| hsa05031 | Amphetamine addiction |
Expression of SIRT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRT1 | 23411 | 218878_s_at | -0.6182 | 0.2008 | |
| GSE20347 | SIRT1 | 23411 | 218878_s_at | -0.1675 | 0.2449 | |
| GSE23400 | SIRT1 | 23411 | 218878_s_at | -0.0290 | 0.7026 | |
| GSE26886 | SIRT1 | 23411 | 218878_s_at | 0.0548 | 0.8676 | |
| GSE29001 | SIRT1 | 23411 | 218878_s_at | -0.0849 | 0.7934 | |
| GSE38129 | SIRT1 | 23411 | 218878_s_at | -0.4283 | 0.0032 | |
| GSE45670 | SIRT1 | 23411 | 218878_s_at | -0.6809 | 0.0000 | |
| GSE53622 | SIRT1 | 23411 | 19197 | -0.3584 | 0.0000 | |
| GSE53624 | SIRT1 | 23411 | 19197 | -0.3679 | 0.0000 | |
| GSE63941 | SIRT1 | 23411 | 218878_s_at | -0.6557 | 0.1341 | |
| GSE77861 | SIRT1 | 23411 | 218878_s_at | 0.1058 | 0.5286 | |
| GSE97050 | SIRT1 | 23411 | A_23_P98022 | -0.3620 | 0.2935 | |
| SRP007169 | SIRT1 | 23411 | RNAseq | -0.0183 | 0.9621 | |
| SRP008496 | SIRT1 | 23411 | RNAseq | 0.3389 | 0.2098 | |
| SRP064894 | SIRT1 | 23411 | RNAseq | -0.6016 | 0.0244 | |
| SRP133303 | SIRT1 | 23411 | RNAseq | 0.0258 | 0.8776 | |
| SRP159526 | SIRT1 | 23411 | RNAseq | -0.4267 | 0.0830 | |
| SRP193095 | SIRT1 | 23411 | RNAseq | -0.1688 | 0.1155 | |
| SRP219564 | SIRT1 | 23411 | RNAseq | -0.2554 | 0.3642 | |
| TCGA | SIRT1 | 23411 | RNAseq | -0.2126 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIRT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRT1 | 23411 | 2 | 5 | 23 | |
| GSE20123 | SIRT1 | 23411 | 2 | 4 | 24 | |
| GSE43470 | SIRT1 | 23411 | 1 | 8 | 34 | |
| GSE46452 | SIRT1 | 23411 | 0 | 11 | 48 | |
| GSE47630 | SIRT1 | 23411 | 2 | 14 | 24 | |
| GSE54993 | SIRT1 | 23411 | 8 | 0 | 62 | |
| GSE54994 | SIRT1 | 23411 | 2 | 12 | 39 | |
| GSE60625 | SIRT1 | 23411 | 0 | 0 | 11 | |
| GSE74703 | SIRT1 | 23411 | 1 | 5 | 30 | |
| GSE74704 | SIRT1 | 23411 | 1 | 3 | 16 | |
| TCGA | SIRT1 | 23411 | 10 | 22 | 64 |
Total number of gains: 29; Total number of losses: 84; Total Number of normals: 375.
Somatic mutations of SIRT1:
Generating mutation plots.
Highly correlated genes for SIRT1:
Showing top 20/956 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRT1 | TTC8 | 0.762073 | 3 | 0 | 3 |
| SIRT1 | TMEM132C | 0.759712 | 3 | 0 | 3 |
| SIRT1 | KBTBD4 | 0.746141 | 3 | 0 | 3 |
| SIRT1 | LSM11 | 0.737696 | 4 | 0 | 4 |
| SIRT1 | FOXN3 | 0.728877 | 4 | 0 | 3 |
| SIRT1 | NTAN1 | 0.726072 | 3 | 0 | 3 |
| SIRT1 | TADA1 | 0.724335 | 4 | 0 | 4 |
| SIRT1 | DIS3L | 0.714057 | 4 | 0 | 3 |
| SIRT1 | SELENBP1 | 0.710865 | 6 | 0 | 5 |
| SIRT1 | COG5 | 0.710219 | 3 | 0 | 3 |
| SIRT1 | EZH1 | 0.710126 | 6 | 0 | 6 |
| SIRT1 | CEP290 | 0.710041 | 3 | 0 | 3 |
| SIRT1 | ADAMTS9-AS2 | 0.70704 | 3 | 0 | 3 |
| SIRT1 | ZNF10 | 0.70655 | 4 | 0 | 4 |
| SIRT1 | HOXA4 | 0.705264 | 4 | 0 | 4 |
| SIRT1 | UBE4B | 0.703503 | 4 | 0 | 3 |
| SIRT1 | PCMTD1 | 0.698333 | 4 | 0 | 4 |
| SIRT1 | AMZ2 | 0.698314 | 3 | 0 | 3 |
| SIRT1 | ANAPC16 | 0.694874 | 5 | 0 | 4 |
| SIRT1 | MAMDC2 | 0.693815 | 5 | 0 | 4 |
For details and further investigation, click here
