SIRT7

 

Full name: sirtuin 7 Alias Symbol: 
Type: protein-coding gene Cytoband: 17q25.3
Entrez ID: 51547 HGNC ID: HGNC:14935 Ensembl Gene: ENSG00000187531 OMIM ID: 606212
Drug and gene relationship at DGIdb

 

Expression of SIRT7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SIRT7 51547 218797_s_at -0.3566 0.4791
GSE20347 SIRT7 51547 218797_s_at -0.8916 0.0000
GSE23400 SIRT7 51547 218797_s_at -0.6369 0.0000
GSE26886 SIRT7 51547 218797_s_at -1.6425 0.0000
GSE29001 SIRT7 51547 218797_s_at -0.9937 0.0035
GSE38129 SIRT7 51547 218797_s_at -0.5381 0.0157
GSE45670 SIRT7 51547 218797_s_at -0.2625 0.1273
GSE53622 SIRT7 51547 93381 -0.3580 0.0000
GSE53624 SIRT7 51547 93381 -0.6222 0.0000
GSE63941 SIRT7 51547 218797_s_at 1.0915 0.0090
GSE77861 SIRT7 51547 218797_s_at -0.3792 0.0570
GSE97050 SIRT7 51547 A_33_P3391727 0.0422 0.8500
SRP007169 SIRT7 51547 RNAseq -2.0840 0.0000
SRP008496 SIRT7 51547 RNAseq -1.9773 0.0000
SRP064894 SIRT7 51547 RNAseq -0.9432 0.0000
SRP133303 SIRT7 51547 RNAseq -0.8890 0.0000
SRP159526 SIRT7 51547 RNAseq -1.1837 0.0000
SRP193095 SIRT7 51547 RNAseq -1.0467 0.0000
SRP219564 SIRT7 51547 RNAseq -1.1678 0.0434
TCGA SIRT7 51547 RNAseq -0.0630 0.4140

Upregulated datasets: 1; Downregulated datasets: 6.  

 

Survival by SIRT7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SIRT7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SIRT7 51547 4 4 22
GSE20123 SIRT7 51547 4 4 22
GSE43470 SIRT7 51547 3 5 35
GSE46452 SIRT7 51547 34 0 25
GSE47630 SIRT7 51547 9 2 29
GSE54993 SIRT7 51547 2 5 63
GSE54994 SIRT7 51547 10 6 37
GSE60625 SIRT7 51547 6 0 5
GSE74703 SIRT7 51547 3 3 30
GSE74704 SIRT7 51547 4 3 13
TCGA SIRT7 51547 25 12 59

Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.  

 

Somatic mutations of SIRT7:

 

Generating mutation plots.

 

Highly correlated genes for SIRT7:

 

Showing top 20/1302 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SIRT7ZNRF10.789354404
SIRT7RAB250.76279212012
SIRT7ATG9B0.757332707
SIRT7TOM10.75228211011
SIRT7NIPAL10.750248303
SIRT7PMM10.74973110010
SIRT7ZFAND2B0.74352606
SIRT7ALOX120.74178110010
SIRT7SNX240.73957510010
SIRT7EPHA10.73923911011
SIRT7RAB11FIP10.7367511009
SIRT7CYP2C90.735071909
SIRT7MXD10.7334861009
SIRT7TTC90.73307712012
SIRT7EVPL0.730813012
SIRT7TRIP100.73064712011
SIRT7EPS8L10.72997513012
SIRT7ESPL10.72962211011
SIRT7PLEKHM10.72525111011
SIRT7CPTP0.724383808

For details and further investigation, click here