| Full name: solute carrier family 1 member 3 | Alias Symbol: EAAT1|GLAST|EA6 | ||
| Type: protein-coding gene | Cytoband: 5p13.2 | ||
| Entrez ID: 6507 | HGNC ID: HGNC:10941 | Ensembl Gene: ENSG00000079215 | OMIM ID: 600111 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SLC1A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC1A3 | 6507 | 202800_at | 0.1401 | 0.8407 | |
| GSE20347 | SLC1A3 | 6507 | 202800_at | -0.1965 | 0.6245 | |
| GSE23400 | SLC1A3 | 6507 | 202800_at | 0.0256 | 0.7971 | |
| GSE26886 | SLC1A3 | 6507 | 202800_at | -1.0178 | 0.0817 | |
| GSE29001 | SLC1A3 | 6507 | 202800_at | -0.6886 | 0.2911 | |
| GSE38129 | SLC1A3 | 6507 | 202800_at | -0.0244 | 0.9473 | |
| GSE45670 | SLC1A3 | 6507 | 202800_at | -0.1672 | 0.7159 | |
| GSE53622 | SLC1A3 | 6507 | 12703 | -0.2096 | 0.2740 | |
| GSE53624 | SLC1A3 | 6507 | 12703 | -0.3587 | 0.0022 | |
| GSE63941 | SLC1A3 | 6507 | 202800_at | 2.9390 | 0.0732 | |
| GSE77861 | SLC1A3 | 6507 | 202800_at | -0.7833 | 0.2086 | |
| GSE97050 | SLC1A3 | 6507 | A_24_P286114 | 0.5770 | 0.3309 | |
| SRP007169 | SLC1A3 | 6507 | RNAseq | 0.3252 | 0.6208 | |
| SRP008496 | SLC1A3 | 6507 | RNAseq | 0.0740 | 0.8574 | |
| SRP064894 | SLC1A3 | 6507 | RNAseq | 0.0400 | 0.9072 | |
| SRP133303 | SLC1A3 | 6507 | RNAseq | -0.4674 | 0.1977 | |
| SRP159526 | SLC1A3 | 6507 | RNAseq | -0.4204 | 0.4386 | |
| SRP193095 | SLC1A3 | 6507 | RNAseq | -0.6507 | 0.0732 | |
| SRP219564 | SLC1A3 | 6507 | RNAseq | -0.4248 | 0.4253 | |
| TCGA | SLC1A3 | 6507 | RNAseq | 0.4125 | 0.0065 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC1A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC1A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC1A3 | 6507 | 10 | 0 | 20 | |
| GSE20123 | SLC1A3 | 6507 | 10 | 0 | 20 | |
| GSE43470 | SLC1A3 | 6507 | 17 | 0 | 26 | |
| GSE46452 | SLC1A3 | 6507 | 5 | 22 | 32 | |
| GSE47630 | SLC1A3 | 6507 | 6 | 12 | 22 | |
| GSE54993 | SLC1A3 | 6507 | 5 | 4 | 61 | |
| GSE54994 | SLC1A3 | 6507 | 26 | 2 | 25 | |
| GSE60625 | SLC1A3 | 6507 | 0 | 0 | 11 | |
| GSE74703 | SLC1A3 | 6507 | 13 | 0 | 23 | |
| GSE74704 | SLC1A3 | 6507 | 9 | 0 | 11 | |
| TCGA | SLC1A3 | 6507 | 52 | 6 | 38 |
Total number of gains: 153; Total number of losses: 46; Total Number of normals: 289.
Somatic mutations of SLC1A3:
Generating mutation plots.
Highly correlated genes for SLC1A3:
Showing top 20/156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC1A3 | FAM107B | 0.663229 | 4 | 0 | 3 |
| SLC1A3 | ARG2 | 0.647296 | 3 | 0 | 3 |
| SLC1A3 | TRMT5 | 0.644832 | 4 | 0 | 4 |
| SLC1A3 | KIAA1522 | 0.638885 | 4 | 0 | 4 |
| SLC1A3 | MBNL3 | 0.637695 | 3 | 0 | 3 |
| SLC1A3 | ZNF681 | 0.634794 | 3 | 0 | 3 |
| SLC1A3 | ABHD6 | 0.632999 | 3 | 0 | 3 |
| SLC1A3 | PDIK1L | 0.631859 | 3 | 0 | 3 |
| SLC1A3 | PHLPP1 | 0.626813 | 3 | 0 | 3 |
| SLC1A3 | LYPD5 | 0.615696 | 3 | 0 | 3 |
| SLC1A3 | STK35 | 0.615584 | 4 | 0 | 3 |
| SLC1A3 | ZNF862 | 0.611507 | 3 | 0 | 3 |
| SLC1A3 | BACE2 | 0.610785 | 4 | 0 | 3 |
| SLC1A3 | FUT11 | 0.61066 | 4 | 0 | 3 |
| SLC1A3 | HDAC1 | 0.609942 | 4 | 0 | 3 |
| SLC1A3 | SRSF10 | 0.60885 | 3 | 0 | 3 |
| SLC1A3 | CNKSR1 | 0.608031 | 6 | 0 | 5 |
| SLC1A3 | TMED9 | 0.607323 | 4 | 0 | 3 |
| SLC1A3 | PDS5A | 0.603756 | 4 | 0 | 4 |
| SLC1A3 | STX3 | 0.602567 | 3 | 0 | 3 |
For details and further investigation, click here
