| Full name: eukaryotic translation termination factor 1 | Alias Symbol: eRF1|TB3-1|RF1 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 2107 | HGNC ID: HGNC:3477 | Ensembl Gene: ENSG00000120705 | OMIM ID: 600285 |
| Drug and gene relationship at DGIdb | |||
Expression of ETF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ETF1 | 2107 | 201574_at | -0.2733 | 0.4729 | |
| GSE20347 | ETF1 | 2107 | 201573_s_at | -0.6027 | 0.0009 | |
| GSE23400 | ETF1 | 2107 | 201574_at | -0.2941 | 0.0000 | |
| GSE26886 | ETF1 | 2107 | 201573_s_at | -0.5941 | 0.0008 | |
| GSE29001 | ETF1 | 2107 | 201573_s_at | -0.6781 | 0.0010 | |
| GSE38129 | ETF1 | 2107 | 201573_s_at | -0.3069 | 0.1090 | |
| GSE45670 | ETF1 | 2107 | 201574_at | -0.2844 | 0.0883 | |
| GSE53622 | ETF1 | 2107 | 80622 | -0.6192 | 0.0000 | |
| GSE53624 | ETF1 | 2107 | 80622 | -0.4517 | 0.0000 | |
| GSE63941 | ETF1 | 2107 | 201574_at | -0.2278 | 0.5276 | |
| GSE77861 | ETF1 | 2107 | 201574_at | -0.3903 | 0.1745 | |
| GSE97050 | ETF1 | A_21_P0013769 | 0.0698 | 0.7919 | ||
| SRP007169 | ETF1 | 2107 | RNAseq | -1.3032 | 0.0014 | |
| SRP008496 | ETF1 | 2107 | RNAseq | -1.3304 | 0.0000 | |
| SRP064894 | ETF1 | 2107 | RNAseq | -0.8259 | 0.0000 | |
| SRP133303 | ETF1 | 2107 | RNAseq | 0.0225 | 0.9278 | |
| SRP159526 | ETF1 | 2107 | RNAseq | -0.6786 | 0.0481 | |
| SRP193095 | ETF1 | 2107 | RNAseq | -0.6999 | 0.0000 | |
| SRP219564 | ETF1 | 2107 | RNAseq | -0.8708 | 0.0003 | |
| TCGA | ETF1 | 2107 | RNAseq | -0.0408 | 0.3414 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ETF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ETF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ETF1 | 2107 | 3 | 10 | 17 | |
| GSE20123 | ETF1 | 2107 | 4 | 10 | 16 | |
| GSE43470 | ETF1 | 2107 | 4 | 5 | 34 | |
| GSE46452 | ETF1 | 2107 | 0 | 27 | 32 | |
| GSE47630 | ETF1 | 2107 | 0 | 21 | 19 | |
| GSE54993 | ETF1 | 2107 | 9 | 1 | 60 | |
| GSE54994 | ETF1 | 2107 | 3 | 13 | 37 | |
| GSE60625 | ETF1 | 2107 | 0 | 0 | 11 | |
| GSE74703 | ETF1 | 2107 | 3 | 4 | 29 | |
| GSE74704 | ETF1 | 2107 | 3 | 4 | 13 | |
| TCGA | ETF1 | 2107 | 3 | 37 | 56 |
Total number of gains: 32; Total number of losses: 132; Total Number of normals: 324.
Somatic mutations of ETF1:
Generating mutation plots.
Highly correlated genes for ETF1:
Showing top 20/1062 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ETF1 | WDFY1 | 0.753144 | 3 | 0 | 3 |
| ETF1 | JMY | 0.724241 | 3 | 0 | 3 |
| ETF1 | CYYR1 | 0.716462 | 3 | 0 | 3 |
| ETF1 | LYSMD3 | 0.715995 | 5 | 0 | 4 |
| ETF1 | RPF1 | 0.715758 | 3 | 0 | 3 |
| ETF1 | CAPNS2 | 0.713965 | 4 | 0 | 3 |
| ETF1 | SLC25A46 | 0.713765 | 7 | 0 | 6 |
| ETF1 | UBE4B | 0.712382 | 3 | 0 | 3 |
| ETF1 | ALKBH7 | 0.703206 | 4 | 0 | 3 |
| ETF1 | UBE2R2 | 0.696099 | 4 | 0 | 3 |
| ETF1 | IPMK | 0.695633 | 3 | 0 | 3 |
| ETF1 | FAM174A | 0.692954 | 7 | 0 | 5 |
| ETF1 | RCOR1 | 0.682713 | 6 | 0 | 6 |
| ETF1 | PCBP1-AS1 | 0.679816 | 3 | 0 | 3 |
| ETF1 | RREB1 | 0.679801 | 7 | 0 | 6 |
| ETF1 | SEC23IP | 0.677533 | 3 | 0 | 3 |
| ETF1 | CPEB4 | 0.676749 | 6 | 0 | 5 |
| ETF1 | ORMDL2 | 0.676621 | 7 | 0 | 6 |
| ETF1 | UQCRQ | 0.674614 | 10 | 0 | 9 |
| ETF1 | SNTB2 | 0.674224 | 3 | 0 | 3 |
For details and further investigation, click here
