| Full name: synaptosome associated protein 25 | Alias Symbol: SNAP-25|RIC-4|RIC4|SEC9|bA416N4.2|dJ1068F16.2 | ||
| Type: protein-coding gene | Cytoband: 20p12.2 | ||
| Entrez ID: 6616 | HGNC ID: HGNC:11132 | Ensembl Gene: ENSG00000132639 | OMIM ID: 600322 |
| Drug and gene relationship at DGIdb | |||
Expression of SNAP25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SNAP25 | 6616 | 202507_s_at | 0.1884 | 0.6645 | |
| GSE20347 | SNAP25 | 6616 | 202507_s_at | -0.0419 | 0.6721 | |
| GSE23400 | SNAP25 | 6616 | 202507_s_at | -0.0692 | 0.0645 | |
| GSE26886 | SNAP25 | 6616 | 202507_s_at | -0.0490 | 0.7399 | |
| GSE29001 | SNAP25 | 6616 | 202507_s_at | -0.1298 | 0.3486 | |
| GSE38129 | SNAP25 | 6616 | 202507_s_at | -0.1223 | 0.1257 | |
| GSE45670 | SNAP25 | 6616 | 202507_s_at | 0.1091 | 0.2418 | |
| GSE53622 | SNAP25 | 6616 | 61178 | 0.6395 | 0.0000 | |
| GSE53624 | SNAP25 | 6616 | 61178 | 0.7932 | 0.0000 | |
| GSE63941 | SNAP25 | 6616 | 202507_s_at | -0.4395 | 0.2562 | |
| GSE77861 | SNAP25 | 6616 | 202507_s_at | -0.0856 | 0.2898 | |
| GSE97050 | SNAP25 | 6616 | A_33_P3338693 | -0.0114 | 0.9685 | |
| SRP133303 | SNAP25 | 6616 | RNAseq | 1.5957 | 0.0005 | |
| SRP159526 | SNAP25 | 6616 | RNAseq | 1.0921 | 0.1887 | |
| SRP219564 | SNAP25 | 6616 | RNAseq | 1.2787 | 0.0442 | |
| TCGA | SNAP25 | 6616 | RNAseq | -1.2382 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SNAP25 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SNAP25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SNAP25 | 6616 | 10 | 1 | 19 | |
| GSE20123 | SNAP25 | 6616 | 10 | 1 | 19 | |
| GSE43470 | SNAP25 | 6616 | 11 | 1 | 31 | |
| GSE46452 | SNAP25 | 6616 | 26 | 1 | 32 | |
| GSE47630 | SNAP25 | 6616 | 18 | 4 | 18 | |
| GSE54993 | SNAP25 | 6616 | 1 | 14 | 55 | |
| GSE54994 | SNAP25 | 6616 | 25 | 1 | 27 | |
| GSE60625 | SNAP25 | 6616 | 0 | 0 | 11 | |
| GSE74703 | SNAP25 | 6616 | 8 | 1 | 27 | |
| GSE74704 | SNAP25 | 6616 | 5 | 1 | 14 | |
| TCGA | SNAP25 | 6616 | 42 | 10 | 44 |
Total number of gains: 156; Total number of losses: 35; Total Number of normals: 297.
Somatic mutations of SNAP25:
Generating mutation plots.
Highly correlated genes for SNAP25:
Showing top 20/581 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SNAP25 | RHAG | 0.757578 | 3 | 0 | 3 |
| SNAP25 | GRID2 | 0.688301 | 4 | 0 | 3 |
| SNAP25 | MATN1 | 0.68271 | 4 | 0 | 4 |
| SNAP25 | TREM1 | 0.679634 | 4 | 0 | 3 |
| SNAP25 | TFF1 | 0.677178 | 4 | 0 | 3 |
| SNAP25 | SIGLEC8 | 0.67548 | 4 | 0 | 4 |
| SNAP25 | HSD17B14 | 0.672136 | 3 | 0 | 3 |
| SNAP25 | PRAMEF12 | 0.668107 | 7 | 0 | 7 |
| SNAP25 | LINC00474 | 0.663699 | 3 | 0 | 3 |
| SNAP25 | DKKL1 | 0.660167 | 4 | 0 | 4 |
| SNAP25 | PSG9 | 0.657919 | 3 | 0 | 3 |
| SNAP25 | MYBPH | 0.65533 | 7 | 0 | 5 |
| SNAP25 | ADAM22 | 0.654665 | 5 | 0 | 4 |
| SNAP25 | MCEMP1 | 0.652805 | 3 | 0 | 3 |
| SNAP25 | ADM2 | 0.651719 | 6 | 0 | 6 |
| SNAP25 | SLC9A5 | 0.650103 | 4 | 0 | 4 |
| SNAP25 | OVGP1 | 0.647719 | 6 | 0 | 5 |
| SNAP25 | ABCC6 | 0.647561 | 3 | 0 | 3 |
| SNAP25 | TSKS | 0.647072 | 3 | 0 | 3 |
| SNAP25 | FBXL20 | 0.646113 | 3 | 0 | 3 |
For details and further investigation, click here
