| Full name: synuclein beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 6620 | HGNC ID: HGNC:11140 | Ensembl Gene: ENSG00000074317 | OMIM ID: 602569 |
| Drug and gene relationship at DGIdb | |||
Expression of SNCB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SNCB | 6620 | 207853_s_at | -0.1073 | 0.6230 | |
| GSE20347 | SNCB | 6620 | 207853_s_at | 0.0006 | 0.9931 | |
| GSE23400 | SNCB | 6620 | 207853_s_at | -0.0953 | 0.0025 | |
| GSE26886 | SNCB | 6620 | 207853_s_at | 0.1366 | 0.1127 | |
| GSE29001 | SNCB | 6620 | 207853_s_at | -0.0325 | 0.8276 | |
| GSE38129 | SNCB | 6620 | 207853_s_at | -0.0098 | 0.9049 | |
| GSE45670 | SNCB | 6620 | 207853_s_at | -0.0003 | 0.9982 | |
| GSE53622 | SNCB | 6620 | 28077 | 0.6268 | 0.0000 | |
| GSE53624 | SNCB | 6620 | 28077 | 0.7049 | 0.0000 | |
| GSE63941 | SNCB | 6620 | 207853_s_at | -0.0339 | 0.8967 | |
| GSE77861 | SNCB | 6620 | 207853_s_at | -0.1809 | 0.1693 | |
| SRP159526 | SNCB | 6620 | RNAseq | 4.7880 | 0.0000 | |
| TCGA | SNCB | 6620 | RNAseq | 3.8009 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SNCB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SNCB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SNCB | 6620 | 2 | 13 | 15 | |
| GSE20123 | SNCB | 6620 | 2 | 13 | 15 | |
| GSE43470 | SNCB | 6620 | 1 | 11 | 31 | |
| GSE46452 | SNCB | 6620 | 0 | 27 | 32 | |
| GSE47630 | SNCB | 6620 | 0 | 20 | 20 | |
| GSE54993 | SNCB | 6620 | 10 | 2 | 58 | |
| GSE54994 | SNCB | 6620 | 2 | 17 | 34 | |
| GSE60625 | SNCB | 6620 | 1 | 0 | 10 | |
| GSE74703 | SNCB | 6620 | 1 | 7 | 28 | |
| GSE74704 | SNCB | 6620 | 1 | 6 | 13 | |
| TCGA | SNCB | 6620 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of SNCB:
Generating mutation plots.
Highly correlated genes for SNCB:
Showing top 20/337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SNCB | SH2D1A | 0.662139 | 3 | 0 | 3 |
| SNCB | FGF23 | 0.659821 | 3 | 0 | 3 |
| SNCB | NR6A1 | 0.654014 | 4 | 0 | 4 |
| SNCB | OPRL1 | 0.647815 | 3 | 0 | 3 |
| SNCB | SMCP | 0.644094 | 3 | 0 | 3 |
| SNCB | GIPC3 | 0.643883 | 3 | 0 | 3 |
| SNCB | DMBT1 | 0.640288 | 4 | 0 | 3 |
| SNCB | AVPR1A | 0.633932 | 4 | 0 | 4 |
| SNCB | KCNJ13 | 0.632841 | 3 | 0 | 3 |
| SNCB | CLEC1B | 0.632346 | 3 | 0 | 3 |
| SNCB | MYL4 | 0.631917 | 4 | 0 | 3 |
| SNCB | OR2H1 | 0.629692 | 3 | 0 | 3 |
| SNCB | ACTL6B | 0.627996 | 5 | 0 | 4 |
| SNCB | MVK | 0.627953 | 4 | 0 | 4 |
| SNCB | CHRNA2 | 0.62773 | 4 | 0 | 4 |
| SNCB | PAX5 | 0.627562 | 3 | 0 | 3 |
| SNCB | CRYGC | 0.623622 | 5 | 0 | 4 |
| SNCB | TPSD1 | 0.62266 | 6 | 0 | 5 |
| SNCB | ADCYAP1R1 | 0.622223 | 6 | 0 | 5 |
| SNCB | C11orf16 | 0.619077 | 5 | 0 | 4 |
For details and further investigation, click here
