SNRNP40

 

Full name: small nuclear ribonucleoprotein U5 subunit 40 Alias Symbol: PRP8BP|SPF38|PRPF8BP|HPRP8BP
Type: protein-coding gene Cytoband: 1p35.2
Entrez ID: 9410 HGNC ID: HGNC:30857 Ensembl Gene: ENSG00000060688 OMIM ID: 607797
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SNRNP40:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SNRNP40 9410 215905_s_at 0.4592 0.2829
GSE20347 SNRNP40 9410 215905_s_at 0.4757 0.0279
GSE23400 SNRNP40 9410 215905_s_at 0.3131 0.0000
GSE26886 SNRNP40 9410 215905_s_at -0.6685 0.0007
GSE29001 SNRNP40 9410 215905_s_at 0.3363 0.2357
GSE38129 SNRNP40 9410 215905_s_at 0.5116 0.0359
GSE45670 SNRNP40 9410 215905_s_at 0.5105 0.0031
GSE53622 SNRNP40 9410 81338 0.6320 0.0000
GSE53624 SNRNP40 9410 81338 0.6411 0.0000
GSE63941 SNRNP40 9410 215905_s_at 0.4945 0.1667
GSE77861 SNRNP40 9410 215905_s_at 0.2916 0.2296
GSE97050 SNRNP40 9410 A_24_P419309 0.2945 0.4563
SRP007169 SNRNP40 9410 RNAseq 1.4346 0.0009
SRP008496 SNRNP40 9410 RNAseq 1.1966 0.0000
SRP064894 SNRNP40 9410 RNAseq 0.7707 0.0000
SRP133303 SNRNP40 9410 RNAseq 0.6885 0.0002
SRP159526 SNRNP40 9410 RNAseq 0.6585 0.0123
SRP193095 SNRNP40 9410 RNAseq 0.3145 0.0018
SRP219564 SNRNP40 9410 RNAseq 0.3186 0.2369
TCGA SNRNP40 9410 RNAseq 0.2555 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SNRNP40 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SNRNP40:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SNRNP40 9410 0 6 24
GSE20123 SNRNP40 9410 0 5 25
GSE43470 SNRNP40 9410 4 6 33
GSE46452 SNRNP40 9410 5 1 53
GSE47630 SNRNP40 9410 8 3 29
GSE54993 SNRNP40 9410 1 1 68
GSE54994 SNRNP40 9410 10 3 40
GSE60625 SNRNP40 9410 0 0 11
GSE74703 SNRNP40 9410 3 4 29
GSE74704 SNRNP40 9410 0 0 20
TCGA SNRNP40 9410 12 18 66

Total number of gains: 43; Total number of losses: 47; Total Number of normals: 398.  

 

Somatic mutations of SNRNP40:

 

Generating mutation plots.

 

Highly correlated genes for SNRNP40:

 

Showing top 20/491 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SNRNP40CCDC1170.773617303
SNRNP40SAP300.711417303
SNRNP40TOMM220.69915707
SNRNP40ZNF5980.688705404
SNRNP40ORC10.6638941008
SNRNP40CDCA80.66295111010
SNRNP40LSM20.658445908
SNRNP40UBL7-AS10.657741605
SNRNP40RCC20.648491504
SNRNP40FANCB0.645888505
SNRNP40POC1A0.644597504
SNRNP40OIP50.639842807
SNRNP40SAAL10.639758505
SNRNP40NDC10.636007907
SNRNP40GINS40.635577505
SNRNP40PRR160.634933404
SNRNP40TSN0.633974806
SNRNP40RRM20.632071807
SNRNP40PLK10.6315851007
SNRNP40CDK20.6303831209

For details and further investigation, click here