SOX9

 

Full name: SRY-box transcription factor 9 Alias Symbol: SRA1
Type: protein-coding gene Cytoband: 17q24.3
Entrez ID: 6662 HGNC ID: HGNC:11204 Ensembl Gene: ENSG00000125398 OMIM ID: 608160
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 14/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SOX9 involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway

 

Expression of SOX9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SOX9 6662 202935_s_at -0.1646 0.9080
GSE20347 SOX9 6662 202935_s_at -0.4714 0.2948
GSE23400 SOX9 6662 202936_s_at 0.0555 0.7657
GSE26886 SOX9 6662 202936_s_at -0.5791 0.1459
GSE29001 SOX9 6662 202936_s_at -0.1706 0.7742
GSE38129 SOX9 6662 202935_s_at 0.2526 0.7129
GSE45670 SOX9 6662 202936_s_at 0.0458 0.9250
GSE53622 SOX9 6662 13141 -0.0608 0.7974
GSE53624 SOX9 6662 13141 -0.3545 0.0057
GSE63941 SOX9 6662 202936_s_at -0.3963 0.8240
GSE77861 SOX9 6662 202936_s_at -0.0756 0.9227
GSE97050 SOX9 6662 A_23_P26847 0.8849 0.3194
SRP007169 SOX9 6662 RNAseq 0.5377 0.2945
SRP008496 SOX9 6662 RNAseq 0.2068 0.5649
SRP064894 SOX9 6662 RNAseq -0.4035 0.2925
SRP133303 SOX9 6662 RNAseq -0.1017 0.7404
SRP159526 SOX9 6662 RNAseq 0.9084 0.1561
SRP193095 SOX9 6662 RNAseq 0.6320 0.0951
SRP219564 SOX9 6662 RNAseq 0.0782 0.9231
TCGA SOX9 6662 RNAseq 0.0866 0.5154

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SOX9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SOX9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SOX9 6662 3 2 25
GSE20123 SOX9 6662 3 2 25
GSE43470 SOX9 6662 6 3 34
GSE46452 SOX9 6662 32 0 27
GSE47630 SOX9 6662 8 1 31
GSE54993 SOX9 6662 2 5 63
GSE54994 SOX9 6662 10 4 39
GSE60625 SOX9 6662 6 0 5
GSE74703 SOX9 6662 6 1 29
GSE74704 SOX9 6662 3 2 15
TCGA SOX9 6662 31 10 55

Total number of gains: 110; Total number of losses: 30; Total Number of normals: 348.  

 

Somatic mutations of SOX9:

 

Generating mutation plots.

 

Highly correlated genes for SOX9:

 

Showing top 20/51 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SOX9ZSWIM10.683126303
SOX9MAP70.660826404
SOX9SDC40.656758303
SOX9PLEKHM20.639902303
SOX9BAIAP2L20.639138303
SOX9ST140.623138303
SOX9ESRP10.606599303
SOX9FAM193B0.606015503
SOX9RCE10.605329303
SOX9PFKFB30.603733504
SOX9EPN10.594104403
SOX9UGCG0.592714403
SOX9SPTSSB0.590294303
SOX9LPAR30.586168503
SOX9LENG80.583392303
SOX9GCM10.58111303
SOX9CLK20.579297403
SOX9SH3BP10.575706303
SOX9NCOA30.572674303
SOX9TSTA30.569719503

For details and further investigation, click here