CAV1

 

Full name: caveolin 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 7q31.2
Entrez ID: 857 HGNC ID: HGNC:1527 Ensembl Gene: ENSG00000105974 OMIM ID: 601047
Drug and gene relationship at DGIdb

 

CAV1 involved pathways:

KEGG pathway Description View
hsa04510Focal adhesion
hsa05205Proteoglycans in cancer

 

Expression of CAV1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CAV1 857 212097_at -0.1421 0.9062
GSE20347 CAV1 857 212097_at 0.3749 0.4579
GSE23400 CAV1 857 212097_at 0.4669 0.0177
GSE26886 CAV1 857 212097_at 1.7142 0.0016
GSE29001 CAV1 857 212097_at 0.8845 0.0463
GSE38129 CAV1 857 212097_at -0.0472 0.9208
GSE45670 CAV1 857 212097_at -0.3370 0.5533
GSE53622 CAV1 857 128053 0.6537 0.0001
GSE53624 CAV1 857 128053 1.0646 0.0000
GSE63941 CAV1 857 212097_at -0.8658 0.5014
GSE77861 CAV1 857 212097_at 1.2717 0.2104
GSE97050 CAV1 857 A_24_P12626 0.1908 0.3405
SRP007169 CAV1 857 RNAseq 2.6665 0.0000
SRP008496 CAV1 857 RNAseq 2.6286 0.0000
SRP064894 CAV1 857 RNAseq 0.7943 0.0043
SRP133303 CAV1 857 RNAseq 1.0883 0.0016
SRP159526 CAV1 857 RNAseq -0.5812 0.2305
SRP193095 CAV1 857 RNAseq 2.2011 0.0000
SRP219564 CAV1 857 RNAseq 0.0719 0.9191
TCGA CAV1 857 RNAseq 0.1102 0.3430

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by CAV1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CAV1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CAV1 857 10 2 18
GSE20123 CAV1 857 11 2 17
GSE43470 CAV1 857 3 2 38
GSE46452 CAV1 857 8 1 50
GSE47630 CAV1 857 7 4 29
GSE54993 CAV1 857 2 7 61
GSE54994 CAV1 857 11 6 36
GSE60625 CAV1 857 0 0 11
GSE74703 CAV1 857 3 2 31
GSE74704 CAV1 857 7 2 11
TCGA CAV1 857 33 17 46

Total number of gains: 95; Total number of losses: 45; Total Number of normals: 348.  

 

Somatic mutations of CAV1:

 

Generating mutation plots.

 

Highly correlated genes for CAV1:

 

Showing top 20/777 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CAV1CAV20.78506713013
CAV1SNTA10.750654303
CAV1ATXN1L0.728003303
CAV1SLC6A60.715434303
CAV1EXOSC100.70974303
CAV1SEMA3C0.7051712012
CAV1KLF70.6994312011
CAV1LGALS10.69913312012
CAV1TGFBR20.6949271009
CAV1ANO60.693153808
CAV1EMP30.68750912012
CAV1ACTN10.68723413011
CAV1FBLIM10.685589606
CAV1LTBP10.68525211010
CAV1SLBP0.684169303
CAV1MTX30.679213303
CAV1PDGFC0.67777912011
CAV1SLC25A300.67774404
CAV1RAB230.676435808
CAV1MICAL20.674932909

For details and further investigation, click here