| Full name: N-acetylglutamate synthase | Alias Symbol: AGAS|ARGA|NAT7 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 162417 | HGNC ID: HGNC:17996 | Ensembl Gene: ENSG00000161653 | OMIM ID: 608300 |
| Drug and gene relationship at DGIdb | |||
Expression of NAGS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NAGS | 162417 | 229432_at | -0.0647 | 0.9610 | |
| GSE26886 | NAGS | 162417 | 229432_at | 0.8083 | 0.0015 | |
| GSE45670 | NAGS | 162417 | 229432_at | 0.2377 | 0.4245 | |
| GSE53622 | NAGS | 162417 | 157491 | 1.0033 | 0.0000 | |
| GSE53624 | NAGS | 162417 | 157491 | 0.7154 | 0.0000 | |
| GSE63941 | NAGS | 162417 | 229432_at | 0.4297 | 0.5144 | |
| GSE77861 | NAGS | 162417 | 229432_at | 0.1281 | 0.6703 | |
| GSE97050 | NAGS | 162417 | A_32_P32739 | 0.4086 | 0.2465 | |
| SRP007169 | NAGS | 162417 | RNAseq | -0.1618 | 0.8434 | |
| SRP064894 | NAGS | 162417 | RNAseq | 0.4712 | 0.1120 | |
| SRP133303 | NAGS | 162417 | RNAseq | 0.4851 | 0.1549 | |
| SRP159526 | NAGS | 162417 | RNAseq | 0.6504 | 0.1788 | |
| SRP193095 | NAGS | 162417 | RNAseq | -0.0128 | 0.9630 | |
| SRP219564 | NAGS | 162417 | RNAseq | -0.7005 | 0.1931 | |
| TCGA | NAGS | 162417 | RNAseq | 1.0234 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NAGS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NAGS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NAGS | 162417 | 5 | 2 | 23 | |
| GSE20123 | NAGS | 162417 | 5 | 2 | 23 | |
| GSE43470 | NAGS | 162417 | 1 | 2 | 40 | |
| GSE46452 | NAGS | 162417 | 32 | 0 | 27 | |
| GSE47630 | NAGS | 162417 | 9 | 0 | 31 | |
| GSE54993 | NAGS | 162417 | 3 | 4 | 63 | |
| GSE54994 | NAGS | 162417 | 8 | 6 | 39 | |
| GSE60625 | NAGS | 162417 | 4 | 0 | 7 | |
| GSE74703 | NAGS | 162417 | 1 | 1 | 34 | |
| GSE74704 | NAGS | 162417 | 3 | 1 | 16 | |
| TCGA | NAGS | 162417 | 23 | 7 | 66 |
Total number of gains: 94; Total number of losses: 25; Total Number of normals: 369.
Somatic mutations of NAGS:
Generating mutation plots.
Highly correlated genes for NAGS:
Showing top 20/409 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NAGS | FARSB | 0.694609 | 3 | 0 | 3 |
| NAGS | RPL26L1 | 0.672857 | 3 | 0 | 3 |
| NAGS | ACOT7 | 0.669199 | 6 | 0 | 6 |
| NAGS | ACAP1 | 0.667844 | 3 | 0 | 3 |
| NAGS | AJAP1 | 0.656063 | 4 | 0 | 3 |
| NAGS | SLC16A3 | 0.651608 | 3 | 0 | 3 |
| NAGS | BLACAT1 | 0.651042 | 3 | 0 | 3 |
| NAGS | AHR | 0.648081 | 4 | 0 | 3 |
| NAGS | STEAP1B | 0.646677 | 4 | 0 | 3 |
| NAGS | CEP85 | 0.645118 | 3 | 0 | 3 |
| NAGS | RDH11 | 0.64494 | 3 | 0 | 3 |
| NAGS | PRR11 | 0.642218 | 3 | 0 | 3 |
| NAGS | RTKN | 0.638959 | 5 | 0 | 5 |
| NAGS | B3GNT5 | 0.637223 | 3 | 0 | 3 |
| NAGS | AMIGO2 | 0.637189 | 5 | 0 | 4 |
| NAGS | PTRH2 | 0.63629 | 5 | 0 | 3 |
| NAGS | SPHK1 | 0.635192 | 3 | 0 | 3 |
| NAGS | PDPN | 0.635124 | 4 | 0 | 3 |
| NAGS | SLC50A1 | 0.632501 | 4 | 0 | 3 |
| NAGS | MELK | 0.631672 | 4 | 0 | 4 |
For details and further investigation, click here
