| Full name: serine and arginine rich splicing factor 3 | Alias Symbol: SRp20 | ||
| Type: protein-coding gene | Cytoband: 6p21.31-p21.2 | ||
| Entrez ID: 6428 | HGNC ID: HGNC:10785 | Ensembl Gene: ENSG00000112081 | OMIM ID: 603364 |
SRSF3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRSF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF3 | 6428 | 208672_s_at | 0.1626 | 0.6753 | |
| GSE20347 | SRSF3 | 6428 | 208672_s_at | 0.4216 | 0.0000 | |
| GSE23400 | SRSF3 | 6428 | 208672_s_at | 0.3483 | 0.0000 | |
| GSE26886 | SRSF3 | 6428 | 208672_s_at | 0.1661 | 0.1511 | |
| GSE29001 | SRSF3 | 6428 | 208672_s_at | 0.3740 | 0.0105 | |
| GSE38129 | SRSF3 | 6428 | 208672_s_at | 0.4062 | 0.0000 | |
| GSE45670 | SRSF3 | 6428 | 208672_s_at | 0.2388 | 0.0130 | |
| GSE53622 | SRSF3 | 6428 | 69215 | 0.0566 | 0.2772 | |
| GSE53624 | SRSF3 | 6428 | 14484 | 0.4466 | 0.0000 | |
| GSE63941 | SRSF3 | 6428 | 208672_s_at | 0.7223 | 0.0003 | |
| GSE77861 | SRSF3 | 6428 | 208672_s_at | 0.1537 | 0.3723 | |
| GSE97050 | SRSF3 | 6428 | A_33_P3232828 | -0.1027 | 0.6934 | |
| SRP007169 | SRSF3 | 6428 | RNAseq | -0.0222 | 0.9374 | |
| SRP008496 | SRSF3 | 6428 | RNAseq | 0.1394 | 0.4663 | |
| SRP064894 | SRSF3 | 6428 | RNAseq | -0.0574 | 0.6680 | |
| SRP133303 | SRSF3 | 6428 | RNAseq | 0.1617 | 0.2073 | |
| SRP159526 | SRSF3 | 6428 | RNAseq | 0.0947 | 0.6974 | |
| SRP193095 | SRSF3 | 6428 | RNAseq | -0.1625 | 0.0498 | |
| SRP219564 | SRSF3 | 6428 | RNAseq | 0.0089 | 0.9654 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRSF3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF3 | 6428 | 6 | 0 | 24 | |
| GSE20123 | SRSF3 | 6428 | 6 | 0 | 24 | |
| GSE43470 | SRSF3 | 6428 | 5 | 1 | 37 | |
| GSE46452 | SRSF3 | 6428 | 2 | 9 | 48 | |
| GSE47630 | SRSF3 | 6428 | 8 | 4 | 28 | |
| GSE54993 | SRSF3 | 6428 | 3 | 1 | 66 | |
| GSE54994 | SRSF3 | 6428 | 10 | 5 | 38 | |
| GSE60625 | SRSF3 | 6428 | 1 | 0 | 10 | |
| GSE74703 | SRSF3 | 6428 | 5 | 0 | 31 | |
| GSE74704 | SRSF3 | 6428 | 3 | 0 | 17 | |
| TCGA | SRSF3 | 6428 | 15 | 15 | 66 |
Total number of gains: 64; Total number of losses: 35; Total Number of normals: 389.
Somatic mutations of SRSF3:
Generating mutation plots.
Highly correlated genes for SRSF3:
Showing top 20/1192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF3 | CCDC124 | 0.764426 | 3 | 0 | 3 |
| SRSF3 | SRSF7 | 0.740063 | 11 | 0 | 10 |
| SRSF3 | EXOC6 | 0.728046 | 3 | 0 | 3 |
| SRSF3 | HNRNPR | 0.717239 | 10 | 0 | 10 |
| SRSF3 | DAPK3 | 0.706489 | 3 | 0 | 3 |
| SRSF3 | LPCAT2 | 0.695846 | 3 | 0 | 3 |
| SRSF3 | ACTL6A | 0.687859 | 10 | 0 | 8 |
| SRSF3 | PAK2 | 0.68197 | 7 | 0 | 7 |
| SRSF3 | ZBTB9 | 0.679359 | 3 | 0 | 3 |
| SRSF3 | MAD2L1 | 0.679224 | 9 | 0 | 8 |
| SRSF3 | KIF15 | 0.67784 | 8 | 0 | 8 |
| SRSF3 | TPX2 | 0.67755 | 8 | 0 | 8 |
| SRSF3 | PFDN2 | 0.67605 | 8 | 0 | 7 |
| SRSF3 | AURKB | 0.675966 | 8 | 0 | 8 |
| SRSF3 | MCM3 | 0.675493 | 9 | 0 | 9 |
| SRSF3 | RAD51AP1 | 0.674686 | 9 | 0 | 8 |
| SRSF3 | TRA2B | 0.674585 | 12 | 0 | 10 |
| SRSF3 | RFC3 | 0.673606 | 10 | 0 | 10 |
| SRSF3 | DEK | 0.671884 | 12 | 0 | 11 |
| SRSF3 | RPS21 | 0.671659 | 4 | 0 | 4 |
For details and further investigation, click here
