| Full name: signal sequence receptor subunit 2 | Alias Symbol: TLAP|TRAPB | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 6746 | HGNC ID: HGNC:11324 | Ensembl Gene: ENSG00000163479 | OMIM ID: 600867 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SSR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SSR2 | 6746 | 200652_at | 0.3712 | 0.2866 | |
| GSE20347 | SSR2 | 6746 | 200652_at | 0.5417 | 0.0002 | |
| GSE23400 | SSR2 | 6746 | 200652_at | 0.5501 | 0.0000 | |
| GSE26886 | SSR2 | 6746 | 200652_at | 0.5944 | 0.0379 | |
| GSE29001 | SSR2 | 6746 | 200652_at | 0.5800 | 0.0628 | |
| GSE38129 | SSR2 | 6746 | 200652_at | 0.6289 | 0.0000 | |
| GSE45670 | SSR2 | 6746 | 200652_at | 0.2864 | 0.0549 | |
| GSE53622 | SSR2 | 6746 | 36465 | 0.7648 | 0.0000 | |
| GSE53624 | SSR2 | 6746 | 130449 | 0.7832 | 0.0000 | |
| GSE63941 | SSR2 | 6746 | 200652_at | -0.1434 | 0.7464 | |
| GSE77861 | SSR2 | 6746 | 200652_at | 0.7411 | 0.0081 | |
| GSE97050 | SSR2 | 6746 | A_24_P282578 | 1.0051 | 0.0706 | |
| SRP007169 | SSR2 | 6746 | RNAseq | -0.1675 | 0.5635 | |
| SRP008496 | SSR2 | 6746 | RNAseq | 0.3339 | 0.1306 | |
| SRP064894 | SSR2 | 6746 | RNAseq | 0.6097 | 0.0477 | |
| SRP133303 | SSR2 | 6746 | RNAseq | 0.6378 | 0.0001 | |
| SRP159526 | SSR2 | 6746 | RNAseq | 0.8156 | 0.0000 | |
| SRP193095 | SSR2 | 6746 | RNAseq | 0.2170 | 0.1450 | |
| SRP219564 | SSR2 | 6746 | RNAseq | 0.4685 | 0.1431 | |
| TCGA | SSR2 | 6746 | RNAseq | -0.0414 | 0.3493 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SSR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SSR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SSR2 | 6746 | 14 | 0 | 16 | |
| GSE20123 | SSR2 | 6746 | 13 | 0 | 17 | |
| GSE43470 | SSR2 | 6746 | 7 | 2 | 34 | |
| GSE46452 | SSR2 | 6746 | 2 | 1 | 56 | |
| GSE47630 | SSR2 | 6746 | 14 | 0 | 26 | |
| GSE54993 | SSR2 | 6746 | 0 | 5 | 65 | |
| GSE54994 | SSR2 | 6746 | 16 | 0 | 37 | |
| GSE60625 | SSR2 | 6746 | 0 | 0 | 11 | |
| GSE74703 | SSR2 | 6746 | 7 | 2 | 27 | |
| GSE74704 | SSR2 | 6746 | 6 | 0 | 14 | |
| TCGA | SSR2 | 6746 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of SSR2:
Generating mutation plots.
Highly correlated genes for SSR2:
Showing top 20/1759 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SSR2 | ILF2 | 0.7837 | 12 | 0 | 12 |
| SSR2 | LSM2 | 0.746479 | 10 | 0 | 10 |
| SSR2 | CCT4 | 0.724279 | 10 | 0 | 10 |
| SSR2 | SNRPE | 0.722517 | 10 | 0 | 8 |
| SSR2 | GNG10 | 0.721421 | 3 | 0 | 3 |
| SSR2 | CKS1B | 0.715587 | 12 | 0 | 12 |
| SSR2 | PDIA5 | 0.712918 | 4 | 0 | 3 |
| SSR2 | PRMT1 | 0.712482 | 12 | 0 | 12 |
| SSR2 | CDK4 | 0.711119 | 12 | 0 | 11 |
| SSR2 | RANBP1 | 0.710984 | 10 | 0 | 10 |
| SSR2 | MRPS12 | 0.710377 | 9 | 0 | 9 |
| SSR2 | PFDN2 | 0.706238 | 11 | 0 | 10 |
| SSR2 | PYCR2 | 0.705793 | 4 | 0 | 3 |
| SSR2 | HSP90AB1 | 0.704955 | 11 | 0 | 11 |
| SSR2 | SOX4 | 0.704864 | 11 | 0 | 10 |
| SSR2 | GORAB | 0.702819 | 7 | 0 | 6 |
| SSR2 | HSPD1 | 0.699822 | 10 | 0 | 10 |
| SSR2 | SNAP47 | 0.69936 | 3 | 0 | 3 |
| SSR2 | RBMX | 0.698002 | 3 | 0 | 3 |
| SSR2 | FANCB | 0.697541 | 4 | 0 | 4 |
For details and further investigation, click here
