HSP90AB1

 

Full name: heat shock protein 90 alpha family class B member 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 6p21.1
Entrez ID: 3326 HGNC ID: HGNC:5258 Ensembl Gene: ENSG00000096384 OMIM ID: 140572
Drug and gene relationship at DGIdb
Screen Evidence:

 

HSP90AB1 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05200Pathways in cancer
hsa05215Prostate cancer

 

Expression of HSP90AB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HSP90AB1 3326 200064_at 0.4544 0.0770
GSE20347 HSP90AB1 3326 200064_at 0.7481 0.0003
GSE23400 HSP90AB1 3326 200064_at 0.8244 0.0000
GSE26886 HSP90AB1 3326 200064_at -0.2315 0.2827
GSE29001 HSP90AB1 3326 200064_at 0.5933 0.1062
GSE38129 HSP90AB1 3326 200064_at 0.8047 0.0000
GSE45670 HSP90AB1 3326 200064_at 0.4994 0.0198
GSE53622 HSP90AB1 3326 39003 0.6474 0.0000
GSE53624 HSP90AB1 3326 39003 1.0149 0.0000
GSE63941 HSP90AB1 3326 200064_at 1.4939 0.0001
GSE77861 HSP90AB1 3326 200064_at 0.4656 0.0316
GSE97050 HSP90AB1 3326 A_24_P823684 0.5679 0.0836
SRP007169 HSP90AB1 3326 RNAseq 0.7320 0.1205
SRP008496 HSP90AB1 3326 RNAseq 0.8918 0.0021
SRP064894 HSP90AB1 3326 RNAseq 0.6224 0.0008
SRP133303 HSP90AB1 3326 RNAseq 0.7195 0.0000
SRP159526 HSP90AB1 3326 RNAseq 0.9095 0.0010
SRP193095 HSP90AB1 3326 RNAseq 0.6411 0.0000
SRP219564 HSP90AB1 3326 RNAseq 0.4877 0.2278
TCGA HSP90AB1 3326 RNAseq 0.1157 0.0008

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by HSP90AB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HSP90AB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HSP90AB1 3326 7 1 22
GSE20123 HSP90AB1 3326 7 1 22
GSE43470 HSP90AB1 3326 6 0 37
GSE46452 HSP90AB1 3326 3 9 47
GSE47630 HSP90AB1 3326 8 4 28
GSE54993 HSP90AB1 3326 3 2 65
GSE54994 HSP90AB1 3326 8 3 42
GSE60625 HSP90AB1 3326 0 2 9
GSE74703 HSP90AB1 3326 6 0 30
GSE74704 HSP90AB1 3326 3 1 16
TCGA HSP90AB1 3326 21 14 61

Total number of gains: 72; Total number of losses: 37; Total Number of normals: 379.  

 

Somatic mutations of HSP90AB1:

 

Generating mutation plots.

 

Highly correlated genes for HSP90AB1:

 

Showing top 20/1131 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HSP90AB1SERPINH10.76706210010
HSP90AB1TUBB0.73855813012
HSP90AB1HSPD10.73486611010
HSP90AB1HSP90AA10.72878310010
HSP90AB1RANBP10.72530611010
HSP90AB1PFDN20.718811009
HSP90AB1TOMM200.713838606
HSP90AB1HSPE10.71174812011
HSP90AB1CCT20.7076910010
HSP90AB1MFAP20.7074681009
HSP90AB1SNRPC0.70736111010
HSP90AB1SSR20.70495511011
HSP90AB1ILF20.7032513011
HSP90AB1SPATC1L0.699948303
HSP90AB1CKS1B0.69749112011
HSP90AB1CCT40.6953071109
HSP90AB1DHX90.689695909
HSP90AB1RUVBL10.68838412010
HSP90AB1PUF600.6849731009
HSP90AB1SSRP10.68110310010

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