| Full name: steroidogenic acute regulatory protein | Alias Symbol: StAR|STARD1 | ||
| Type: protein-coding gene | Cytoband: 8p11.23 | ||
| Entrez ID: 6770 | HGNC ID: HGNC:11359 | Ensembl Gene: ENSG00000147465 | OMIM ID: 600617 |
| Drug and gene relationship at DGIdb | |||
STAR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis | |
| hsa04925 | Aldosterone synthesis and secretion |
Expression of STAR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STAR | 6770 | 204548_at | -0.0982 | 0.8708 | |
| GSE20347 | STAR | 6770 | 204548_at | 0.0896 | 0.7296 | |
| GSE23400 | STAR | 6770 | 204548_at | -0.0742 | 0.2601 | |
| GSE26886 | STAR | 6770 | 204548_at | -0.6091 | 0.0212 | |
| GSE29001 | STAR | 6770 | 204548_at | 0.1369 | 0.8169 | |
| GSE38129 | STAR | 6770 | 204548_at | 0.1304 | 0.5729 | |
| GSE45670 | STAR | 6770 | 204548_at | -0.2649 | 0.1673 | |
| GSE53622 | STAR | 6770 | 38630 | 0.2047 | 0.5384 | |
| GSE53624 | STAR | 6770 | 38630 | -0.5680 | 0.0074 | |
| GSE63941 | STAR | 6770 | 204548_at | -0.0889 | 0.6403 | |
| GSE77861 | STAR | 6770 | 204548_at | -0.1874 | 0.2134 | |
| GSE97050 | STAR | 6770 | A_23_P8981 | 0.5071 | 0.2035 | |
| SRP064894 | STAR | 6770 | RNAseq | -0.2704 | 0.3372 | |
| SRP133303 | STAR | 6770 | RNAseq | -0.1599 | 0.5268 | |
| SRP159526 | STAR | 6770 | RNAseq | 0.9937 | 0.2189 | |
| SRP193095 | STAR | 6770 | RNAseq | 0.0409 | 0.8536 | |
| SRP219564 | STAR | 6770 | RNAseq | -1.1192 | 0.0875 | |
| TCGA | STAR | 6770 | RNAseq | 0.3036 | 0.3219 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STAR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STAR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STAR | 6770 | 10 | 4 | 16 | |
| GSE20123 | STAR | 6770 | 11 | 4 | 15 | |
| GSE43470 | STAR | 6770 | 8 | 7 | 28 | |
| GSE46452 | STAR | 6770 | 23 | 4 | 32 | |
| GSE47630 | STAR | 6770 | 12 | 7 | 21 | |
| GSE54993 | STAR | 6770 | 2 | 16 | 52 | |
| GSE54994 | STAR | 6770 | 16 | 8 | 29 | |
| GSE60625 | STAR | 6770 | 3 | 0 | 8 | |
| GSE74703 | STAR | 6770 | 8 | 5 | 23 | |
| GSE74704 | STAR | 6770 | 9 | 1 | 10 | |
| TCGA | STAR | 6770 | 35 | 25 | 36 |
Total number of gains: 137; Total number of losses: 81; Total Number of normals: 270.
Somatic mutations of STAR:
Generating mutation plots.
Highly correlated genes for STAR:
Showing top 20/72 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STAR | C12orf40 | 0.699279 | 3 | 0 | 3 |
| STAR | PRB1 | 0.680273 | 3 | 0 | 3 |
| STAR | DEPDC4 | 0.654027 | 3 | 0 | 3 |
| STAR | B3GALT2 | 0.640461 | 3 | 0 | 3 |
| STAR | SPECC1 | 0.639864 | 3 | 0 | 3 |
| STAR | RETNLB | 0.637745 | 4 | 0 | 3 |
| STAR | SYN1 | 0.635364 | 3 | 0 | 3 |
| STAR | ATP6V1C2 | 0.634635 | 4 | 0 | 4 |
| STAR | GRAP2 | 0.632947 | 3 | 0 | 3 |
| STAR | MPND | 0.626161 | 4 | 0 | 4 |
| STAR | PHYHD1 | 0.619452 | 4 | 0 | 3 |
| STAR | CNIH3 | 0.615056 | 3 | 0 | 3 |
| STAR | TRIM13 | 0.615007 | 3 | 0 | 3 |
| STAR | TRPC4 | 0.613671 | 4 | 0 | 3 |
| STAR | TEX264 | 0.612978 | 3 | 0 | 3 |
| STAR | LTA | 0.612702 | 3 | 0 | 3 |
| STAR | IL1R2 | 0.611414 | 4 | 0 | 3 |
| STAR | ATG13 | 0.604873 | 3 | 0 | 3 |
| STAR | KRTAP5-8 | 0.596748 | 4 | 0 | 3 |
| STAR | FBL | 0.596185 | 5 | 0 | 4 |
For details and further investigation, click here
