| Full name: cyclin dependent kinase 5 | Alias Symbol: PSSALRE | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 1020 | HGNC ID: HGNC:1774 | Ensembl Gene: ENSG00000164885 | OMIM ID: 123831 |
| Drug and gene relationship at DGIdb | |||
CDK5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance | |
| hsa05010 | Alzheimer's disease | |
| hsa05030 | Cocaine addiction |
Expression of CDK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK5 | 1020 | 204247_s_at | 0.4592 | 0.4702 | |
| GSE20347 | CDK5 | 1020 | 204247_s_at | 0.2456 | 0.1311 | |
| GSE23400 | CDK5 | 1020 | 204247_s_at | 0.1639 | 0.0048 | |
| GSE26886 | CDK5 | 1020 | 204247_s_at | -0.3146 | 0.3848 | |
| GSE29001 | CDK5 | 1020 | 204247_s_at | 0.3459 | 0.2772 | |
| GSE38129 | CDK5 | 1020 | 204247_s_at | 0.4395 | 0.0005 | |
| GSE45670 | CDK5 | 1020 | 204247_s_at | 0.4103 | 0.0343 | |
| GSE53622 | CDK5 | 1020 | 91388 | 0.5016 | 0.0000 | |
| GSE53624 | CDK5 | 1020 | 91388 | 0.5876 | 0.0000 | |
| GSE63941 | CDK5 | 1020 | 204247_s_at | -0.0178 | 0.9745 | |
| GSE77861 | CDK5 | 1020 | 204247_s_at | 0.1812 | 0.5939 | |
| GSE97050 | CDK5 | 1020 | A_23_P8400 | 0.3699 | 0.2349 | |
| SRP007169 | CDK5 | 1020 | RNAseq | 0.2377 | 0.5659 | |
| SRP008496 | CDK5 | 1020 | RNAseq | 0.1122 | 0.6724 | |
| SRP064894 | CDK5 | 1020 | RNAseq | 1.2417 | 0.0001 | |
| SRP133303 | CDK5 | 1020 | RNAseq | 0.5240 | 0.0070 | |
| SRP159526 | CDK5 | 1020 | RNAseq | 0.4407 | 0.1471 | |
| SRP193095 | CDK5 | 1020 | RNAseq | 0.1633 | 0.2519 | |
| SRP219564 | CDK5 | 1020 | RNAseq | 0.1784 | 0.5529 | |
| TCGA | CDK5 | 1020 | RNAseq | 0.2804 | 0.0011 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CDK5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK5 | 1020 | 2 | 4 | 24 | |
| GSE20123 | CDK5 | 1020 | 2 | 4 | 24 | |
| GSE43470 | CDK5 | 1020 | 2 | 5 | 36 | |
| GSE46452 | CDK5 | 1020 | 7 | 2 | 50 | |
| GSE47630 | CDK5 | 1020 | 5 | 9 | 26 | |
| GSE54993 | CDK5 | 1020 | 3 | 3 | 64 | |
| GSE54994 | CDK5 | 1020 | 5 | 8 | 40 | |
| GSE60625 | CDK5 | 1020 | 0 | 0 | 11 | |
| GSE74703 | CDK5 | 1020 | 2 | 4 | 30 | |
| GSE74704 | CDK5 | 1020 | 1 | 4 | 15 | |
| TCGA | CDK5 | 1020 | 26 | 25 | 45 |
Total number of gains: 55; Total number of losses: 68; Total Number of normals: 365.
Somatic mutations of CDK5:
Generating mutation plots.
Highly correlated genes for CDK5:
Showing top 20/819 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK5 | TXNDC12 | 0.733359 | 4 | 0 | 4 |
| CDK5 | ALG10 | 0.7178 | 4 | 0 | 4 |
| CDK5 | NOP56 | 0.702824 | 3 | 0 | 3 |
| CDK5 | SLX4IP | 0.701848 | 3 | 0 | 3 |
| CDK5 | GTPBP3 | 0.698653 | 4 | 0 | 4 |
| CDK5 | PRELID1 | 0.696083 | 3 | 0 | 3 |
| CDK5 | GOLT1B | 0.694858 | 5 | 0 | 5 |
| CDK5 | CENPW | 0.694593 | 4 | 0 | 3 |
| CDK5 | SPNS1 | 0.688113 | 4 | 0 | 4 |
| CDK5 | RAD18 | 0.682909 | 3 | 0 | 3 |
| CDK5 | KIAA1522 | 0.680874 | 3 | 0 | 3 |
| CDK5 | SNAP47 | 0.680292 | 3 | 0 | 3 |
| CDK5 | PMM2 | 0.67899 | 4 | 0 | 4 |
| CDK5 | SMC2 | 0.66555 | 6 | 0 | 6 |
| CDK5 | DUS4L | 0.663156 | 8 | 0 | 6 |
| CDK5 | DNASE2 | 0.662466 | 5 | 0 | 5 |
| CDK5 | TBC1D7 | 0.661996 | 3 | 0 | 3 |
| CDK5 | TATDN2 | 0.656329 | 4 | 0 | 4 |
| CDK5 | ESCO2 | 0.654602 | 5 | 0 | 5 |
| CDK5 | MRPL38 | 0.654439 | 4 | 0 | 3 |
For details and further investigation, click here
