| Full name: tryptophan 2,3-dioxygenase | Alias Symbol: TDO|TPH2 | ||
| Type: protein-coding gene | Cytoband: 4q32.1 | ||
| Entrez ID: 6999 | HGNC ID: HGNC:11708 | Ensembl Gene: ENSG00000151790 | OMIM ID: 191070 |
| Drug and gene relationship at DGIdb | |||
Expression of TDO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TDO2 | 6999 | 205943_at | 2.2511 | 0.1393 | |
| GSE20347 | TDO2 | 6999 | 205943_at | 0.9341 | 0.0005 | |
| GSE23400 | TDO2 | 6999 | 205943_at | 0.5301 | 0.0000 | |
| GSE26886 | TDO2 | 6999 | 205943_at | 0.8600 | 0.1715 | |
| GSE29001 | TDO2 | 6999 | 205943_at | 0.2560 | 0.4106 | |
| GSE38129 | TDO2 | 6999 | 205943_at | 1.5830 | 0.0000 | |
| GSE45670 | TDO2 | 6999 | 205943_at | 2.2015 | 0.0001 | |
| GSE53622 | TDO2 | 6999 | 217 | 2.4732 | 0.0000 | |
| GSE53624 | TDO2 | 6999 | 217 | 2.1020 | 0.0000 | |
| GSE63941 | TDO2 | 6999 | 205943_at | -1.3850 | 0.1370 | |
| GSE77861 | TDO2 | 6999 | 231702_at | -0.0808 | 0.5237 | |
| GSE97050 | TDO2 | 6999 | A_23_P80974 | 1.6518 | 0.0684 | |
| SRP064894 | TDO2 | 6999 | RNAseq | 3.6220 | 0.0000 | |
| SRP133303 | TDO2 | 6999 | RNAseq | 2.3050 | 0.0000 | |
| SRP159526 | TDO2 | 6999 | RNAseq | 2.3816 | 0.0000 | |
| TCGA | TDO2 | 6999 | RNAseq | 2.9604 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by TDO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TDO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TDO2 | 6999 | 0 | 14 | 16 | |
| GSE20123 | TDO2 | 6999 | 0 | 14 | 16 | |
| GSE43470 | TDO2 | 6999 | 0 | 14 | 29 | |
| GSE46452 | TDO2 | 6999 | 1 | 36 | 22 | |
| GSE47630 | TDO2 | 6999 | 0 | 23 | 17 | |
| GSE54993 | TDO2 | 6999 | 10 | 0 | 60 | |
| GSE54994 | TDO2 | 6999 | 1 | 12 | 40 | |
| GSE60625 | TDO2 | 6999 | 0 | 1 | 10 | |
| GSE74703 | TDO2 | 6999 | 0 | 12 | 24 | |
| GSE74704 | TDO2 | 6999 | 0 | 7 | 13 | |
| TCGA | TDO2 | 6999 | 10 | 36 | 50 |
Total number of gains: 22; Total number of losses: 169; Total Number of normals: 297.
Somatic mutations of TDO2:
Generating mutation plots.
Highly correlated genes for TDO2:
Showing top 20/834 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TDO2 | ALPK2 | 0.803919 | 3 | 0 | 3 |
| TDO2 | FCGR3A | 0.746128 | 3 | 0 | 3 |
| TDO2 | LRRC8C | 0.744309 | 3 | 0 | 3 |
| TDO2 | FAM89A | 0.740909 | 3 | 0 | 3 |
| TDO2 | HELB | 0.730173 | 3 | 0 | 3 |
| TDO2 | MEX3B | 0.719778 | 4 | 0 | 4 |
| TDO2 | PLA2G7 | 0.708073 | 11 | 0 | 10 |
| TDO2 | DCBLD1 | 0.70171 | 7 | 0 | 6 |
| TDO2 | SKA3 | 0.694628 | 3 | 0 | 3 |
| TDO2 | MMS22L | 0.694102 | 3 | 0 | 3 |
| TDO2 | LRRC15 | 0.692105 | 9 | 0 | 8 |
| TDO2 | SHCBP1 | 0.69128 | 9 | 0 | 9 |
| TDO2 | TLR2 | 0.691277 | 9 | 0 | 8 |
| TDO2 | CTRB2 | 0.687662 | 3 | 0 | 3 |
| TDO2 | CCDC18 | 0.687065 | 3 | 0 | 3 |
| TDO2 | NLRP3 | 0.685798 | 3 | 0 | 3 |
| TDO2 | ZNF789 | 0.68461 | 3 | 0 | 3 |
| TDO2 | THSD1 | 0.68447 | 3 | 0 | 3 |
| TDO2 | GPR84 | 0.682425 | 5 | 0 | 4 |
| TDO2 | CHSY3 | 0.676648 | 5 | 0 | 5 |
For details and further investigation, click here
