SHCBP1

 

Full name: SHC binding and spindle associated 1 Alias Symbol: FLJ22009|PAL
Type: protein-coding gene Cytoband: 16q11.2
Entrez ID: 79801 HGNC ID: HGNC:29547 Ensembl Gene: ENSG00000171241 OMIM ID: 611027
Drug and gene relationship at DGIdb

 

Expression of SHCBP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SHCBP1 79801 219493_at 1.3129 0.1257
GSE20347 SHCBP1 79801 219493_at 1.2868 0.0000
GSE23400 SHCBP1 79801 219493_at 0.6730 0.0000
GSE26886 SHCBP1 79801 219493_at 0.5997 0.2072
GSE29001 SHCBP1 79801 219493_at 1.4510 0.0016
GSE38129 SHCBP1 79801 219493_at 1.7532 0.0000
GSE45670 SHCBP1 79801 219493_at 1.5558 0.0000
GSE53622 SHCBP1 79801 24590 1.3003 0.0000
GSE53624 SHCBP1 79801 24590 1.3447 0.0000
GSE63941 SHCBP1 79801 219493_at 1.3581 0.1559
GSE77861 SHCBP1 79801 219493_at 0.7010 0.0339
GSE97050 SHCBP1 79801 A_32_P96719 0.5816 0.1241
SRP007169 SHCBP1 79801 RNAseq 1.3282 0.0037
SRP008496 SHCBP1 79801 RNAseq 0.9336 0.0143
SRP064894 SHCBP1 79801 RNAseq 1.0991 0.0000
SRP133303 SHCBP1 79801 RNAseq 0.9804 0.0000
SRP159526 SHCBP1 79801 RNAseq 0.8648 0.0010
SRP193095 SHCBP1 79801 RNAseq 0.8289 0.0000
SRP219564 SHCBP1 79801 RNAseq 1.1463 0.1189
TCGA SHCBP1 79801 RNAseq 1.1760 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by SHCBP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SHCBP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SHCBP1 79801 2 2 26
GSE20123 SHCBP1 79801 2 2 26
GSE43470 SHCBP1 79801 2 7 34
GSE46452 SHCBP1 79801 38 1 20
GSE47630 SHCBP1 79801 11 7 22
GSE54993 SHCBP1 79801 2 5 63
GSE54994 SHCBP1 79801 6 10 37
GSE60625 SHCBP1 79801 4 0 7
GSE74703 SHCBP1 79801 2 4 30
GSE74704 SHCBP1 79801 2 2 16
TCGA SHCBP1 79801 29 11 56

Total number of gains: 100; Total number of losses: 51; Total Number of normals: 337.  

 

Somatic mutations of SHCBP1:

 

Generating mutation plots.

 

Highly correlated genes for SHCBP1:

 

Showing top 20/1643 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SHCBP1HMMR0.80143612012
SHCBP1CDC200.7809111011
SHCBP1GINS10.77292212012
SHCBP1KIF20A0.76444312012
SHCBP1CENPN0.76272612012
SHCBP1CKAP2L0.761546808
SHCBP1FEN10.758626909
SHCBP1ORC60.75508811011
SHCBP1C1orf1310.752249606
SHCBP1MCM100.75042311011
SHCBP1KPNA20.74904410010
SHCBP1DCBLD10.74753707
SHCBP1FAM89A0.74595303
SHCBP1TTK0.74579712012
SHCBP1DEPDC1B0.745594707
SHCBP1DTL0.74374712011
SHCBP1BIRC50.74374412011
SHCBP1KIF140.74269612012
SHCBP1GART0.74225210010
SHCBP1UBE2C0.74133712012

For details and further investigation, click here