LRRC15

 

Full name: leucine rich repeat containing 15 Alias Symbol: LIB
Type: protein-coding gene Cytoband: 3q29
Entrez ID: 131578 HGNC ID: HGNC:20818 Ensembl Gene: ENSG00000172061 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of LRRC15:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRRC15 131578 213909_at 1.2675 0.0641
GSE20347 LRRC15 131578 213909_at 0.8044 0.0002
GSE23400 LRRC15 131578 213909_at 0.5408 0.0000
GSE26886 LRRC15 131578 213909_at 0.9317 0.0630
GSE29001 LRRC15 131578 213909_at 0.9207 0.0009
GSE38129 LRRC15 131578 213909_at 1.0776 0.0000
GSE45670 LRRC15 131578 213909_at 0.5855 0.1427
GSE53622 LRRC15 131578 90143 3.9677 0.0000
GSE53624 LRRC15 131578 90143 3.8565 0.0000
GSE63941 LRRC15 131578 213909_at -0.4998 0.0719
GSE77861 LRRC15 131578 213909_at 0.0353 0.8834
GSE97050 LRRC15 131578 A_24_P827037 1.1578 0.0835
SRP007169 LRRC15 131578 RNAseq 8.1110 0.0000
SRP008496 LRRC15 131578 RNAseq 7.5742 0.0000
SRP064894 LRRC15 131578 RNAseq 5.2390 0.0000
SRP133303 LRRC15 131578 RNAseq 5.7699 0.0000
SRP159526 LRRC15 131578 RNAseq 2.6090 0.0001
SRP219564 LRRC15 131578 RNAseq 4.8388 0.0000
TCGA LRRC15 131578 RNAseq 0.6980 0.0087

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by LRRC15 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRRC15:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRRC15 131578 22 0 8
GSE20123 LRRC15 131578 22 0 8
GSE43470 LRRC15 131578 24 0 19
GSE46452 LRRC15 131578 19 1 39
GSE47630 LRRC15 131578 27 2 11
GSE54993 LRRC15 131578 1 21 48
GSE54994 LRRC15 131578 41 0 12
GSE60625 LRRC15 131578 0 6 5
GSE74703 LRRC15 131578 20 0 16
GSE74704 LRRC15 131578 14 0 6
TCGA LRRC15 131578 77 0 19

Total number of gains: 267; Total number of losses: 30; Total Number of normals: 191.  

 

Somatic mutations of LRRC15:

 

Generating mutation plots.

 

Highly correlated genes for LRRC15:

 

Showing top 20/693 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRRC15ADAMTS120.820529707
LRRC15COL10A10.77653411011
LRRC15GPR840.760151303
LRRC15COL11A10.75145812011
LRRC15CTHRC10.751316707
LRRC15MMP110.7431741009
LRRC15ZNF4690.732641707
LRRC15C1QTNF60.729133605
LRRC15THBS20.7228312012
LRRC15MFAP20.70409510010
LRRC15MMP10.69954511011
LRRC15POSTN0.69659112011
LRRC15COL5A20.69658712010
LRRC15FAP0.6923781008
LRRC15TDO20.692105908
LRRC15THY10.69144612011
LRRC15CHSY30.690262706
LRRC15COL3A10.68517112011
LRRC15CTSK0.6842612012
LRRC15COL1A10.6796831109

For details and further investigation, click here