TLR2

 

Full name: toll like receptor 2 Alias Symbol: TIL4|CD282
Type: protein-coding gene Cytoband: 4q31.3
Entrez ID: 7097 HGNC ID: HGNC:11848 Ensembl Gene: ENSG00000137462 OMIM ID: 603028
Drug and gene relationship at DGIdb

 

TLR2 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05162Measles
hsa05168Herpes simplex infection
hsa05205Proteoglycans in cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of TLR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TLR2 7097 204924_at 1.2061 0.1717
GSE20347 TLR2 7097 204924_at 0.6438 0.0004
GSE23400 TLR2 7097 204924_at 0.5095 0.0000
GSE26886 TLR2 7097 204924_at 1.4558 0.0001
GSE29001 TLR2 7097 204924_at 1.6430 0.0000
GSE38129 TLR2 7097 204924_at 0.9177 0.0000
GSE45670 TLR2 7097 204924_at 1.0890 0.0010
GSE53622 TLR2 7097 78832 1.6085 0.0000
GSE53624 TLR2 7097 78832 1.6021 0.0000
GSE63941 TLR2 7097 204924_at 0.5905 0.5182
GSE77861 TLR2 7097 204924_at 0.8914 0.0034
GSE97050 TLR2 7097 A_23_P92499 1.1488 0.0465
SRP007169 TLR2 7097 RNAseq 1.6991 0.0084
SRP008496 TLR2 7097 RNAseq 2.6232 0.0002
SRP064894 TLR2 7097 RNAseq 1.9180 0.0000
SRP133303 TLR2 7097 RNAseq 1.4741 0.0000
SRP159526 TLR2 7097 RNAseq 1.4194 0.0253
SRP193095 TLR2 7097 RNAseq 2.0852 0.0000
SRP219564 TLR2 7097 RNAseq 1.8086 0.0001
TCGA TLR2 7097 RNAseq 0.5341 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by TLR2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TLR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TLR2 7097 0 14 16
GSE20123 TLR2 7097 0 14 16
GSE43470 TLR2 7097 0 13 30
GSE46452 TLR2 7097 1 36 22
GSE47630 TLR2 7097 0 23 17
GSE54993 TLR2 7097 10 0 60
GSE54994 TLR2 7097 1 13 39
GSE60625 TLR2 7097 0 1 10
GSE74703 TLR2 7097 0 11 25
GSE74704 TLR2 7097 0 7 13
TCGA TLR2 7097 10 35 51

Total number of gains: 22; Total number of losses: 167; Total Number of normals: 299.  

 

Somatic mutations of TLR2:

 

Generating mutation plots.

 

Highly correlated genes for TLR2:

 

Showing top 20/1792 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TLR2FCGR3A0.831691303
TLR2WDR810.781419404
TLR2LRRC8C0.780081303
TLR2TMC80.780063303
TLR2FAM89A0.754641303
TLR2TIGD10.739841303
TLR2IKBIP0.73524606
TLR2C6orf1410.728141303
TLR2ARPC1B0.72610611011
TLR2MMP120.72416611011
TLR2SUCNR10.722332404
TLR2ALPK20.720856303
TLR2SLC43A20.717824606
TLR2SLC6A60.717523504
TLR2CPT1A0.716234303
TLR2CLSPN0.712331505
TLR2CCNB1IP10.711943303
TLR2TTC39C0.711263303
TLR2SH3PXD2B0.710204707
TLR2CCDC1270.709486303

For details and further investigation, click here