IL1R1

 

Full name: interleukin 1 receptor type 1 Alias Symbol: D2S1473|CD121A
Type: protein-coding gene Cytoband: 2q11.2-q12.1
Entrez ID: 3554 HGNC ID: HGNC:5993 Ensembl Gene: ENSG00000115594 OMIM ID: 147810
Drug and gene relationship at DGIdb
Screen Evidence:

 

IL1R1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04380Osteoclast differentiation
hsa04750Inflammatory mediator regulation of TRP channels
hsa05166HTLV-I infection

 

Expression of IL1R1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL1R1 3554 202948_at -0.4097 0.4970
GSE20347 IL1R1 3554 202948_at -0.2299 0.2871
GSE23400 IL1R1 3554 202948_at 0.2507 0.0400
GSE26886 IL1R1 3554 202948_at -0.3393 0.3811
GSE29001 IL1R1 3554 202948_at -0.1147 0.7684
GSE38129 IL1R1 3554 202948_at -0.1338 0.5679
GSE45670 IL1R1 3554 202948_at -0.6694 0.0041
GSE53622 IL1R1 3554 44236 0.1239 0.2759
GSE53624 IL1R1 3554 44236 0.1937 0.0387
GSE63941 IL1R1 3554 202948_at -4.9524 0.0042
GSE77861 IL1R1 3554 202948_at 0.3004 0.4492
GSE97050 IL1R1 3554 A_33_P3396389 0.6794 0.1748
SRP007169 IL1R1 3554 RNAseq 0.2868 0.5229
SRP008496 IL1R1 3554 RNAseq 0.8714 0.0005
SRP064894 IL1R1 3554 RNAseq 0.4028 0.2470
SRP133303 IL1R1 3554 RNAseq 0.3271 0.3092
SRP159526 IL1R1 3554 RNAseq 0.2467 0.4708
SRP193095 IL1R1 3554 RNAseq 0.2906 0.0981
SRP219564 IL1R1 3554 RNAseq 0.1584 0.7667
TCGA IL1R1 3554 RNAseq -0.2457 0.0022

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by IL1R1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL1R1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL1R1 3554 5 2 23
GSE20123 IL1R1 3554 5 2 23
GSE43470 IL1R1 3554 5 1 37
GSE46452 IL1R1 3554 1 4 54
GSE47630 IL1R1 3554 7 0 33
GSE54993 IL1R1 3554 0 6 64
GSE54994 IL1R1 3554 11 0 42
GSE60625 IL1R1 3554 0 3 8
GSE74703 IL1R1 3554 5 1 30
GSE74704 IL1R1 3554 3 1 16
TCGA IL1R1 3554 34 6 56

Total number of gains: 76; Total number of losses: 26; Total Number of normals: 386.  

 

Somatic mutations of IL1R1:

 

Generating mutation plots.

 

Highly correlated genes for IL1R1:

 

Showing top 20/407 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL1R1HAUS10.791731303
IL1R1SYNPO20.6918303
IL1R1MRC10.680313707
IL1R1BICC10.677781807
IL1R1NNMT0.675089403
IL1R1PLEK0.669527303
IL1R1CSGALNACT10.664124706
IL1R1CRISPLD20.6635781009
IL1R1SPON10.6570021109
IL1R1GK0.656093403
IL1R1F30.653796403
IL1R1C11orf960.653387404
IL1R1SNX130.650867303
IL1R1IRAK30.648194605
IL1R1ARHGAP290.642705706
IL1R1HPS50.642405303
IL1R1FMOD0.640662908
IL1R1CMTM60.638632504
IL1R1ACP20.637395303
IL1R1PCAT190.637072303

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