LMNB1

 

Full name: lamin B1 Alias Symbol: 
Type: protein-coding gene Cytoband: 5q23.2
Entrez ID: 4001 HGNC ID: HGNC:6637 Ensembl Gene: ENSG00000113368 OMIM ID: 150340
Drug and gene relationship at DGIdb
Screen Evidence:

 

LMNB1 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of LMNB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LMNB1 4001 203276_at 1.1251 0.0300
GSE20347 LMNB1 4001 203276_at 0.7013 0.0003
GSE23400 LMNB1 4001 203276_at 1.1263 0.0000
GSE26886 LMNB1 4001 203276_at 0.6038 0.0506
GSE29001 LMNB1 4001 203276_at 1.0687 0.0083
GSE38129 LMNB1 4001 203276_at 1.4932 0.0000
GSE45670 LMNB1 4001 203276_at 0.8454 0.0029
GSE53622 LMNB1 4001 3146 0.9699 0.0000
GSE53624 LMNB1 4001 3146 1.0320 0.0000
GSE63941 LMNB1 4001 203276_at 4.0618 0.0000
GSE77861 LMNB1 4001 203276_at 0.3176 0.2880
GSE97050 LMNB1 4001 A_23_P258493 0.6336 0.1279
SRP007169 LMNB1 4001 RNAseq 2.8243 0.0000
SRP008496 LMNB1 4001 RNAseq 2.3609 0.0001
SRP064894 LMNB1 4001 RNAseq 0.8938 0.0018
SRP133303 LMNB1 4001 RNAseq 1.0493 0.0000
SRP159526 LMNB1 4001 RNAseq 1.0435 0.0045
SRP193095 LMNB1 4001 RNAseq 0.4392 0.0000
SRP219564 LMNB1 4001 RNAseq 0.9283 0.1218
TCGA LMNB1 4001 RNAseq 0.7489 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by LMNB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LMNB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LMNB1 4001 1 12 17
GSE20123 LMNB1 4001 1 12 17
GSE43470 LMNB1 4001 3 8 32
GSE46452 LMNB1 4001 0 27 32
GSE47630 LMNB1 4001 0 21 19
GSE54993 LMNB1 4001 9 1 60
GSE54994 LMNB1 4001 2 15 36
GSE60625 LMNB1 4001 0 0 11
GSE74703 LMNB1 4001 2 6 28
GSE74704 LMNB1 4001 1 6 13
TCGA LMNB1 4001 2 40 54

Total number of gains: 21; Total number of losses: 148; Total Number of normals: 319.  

 

Somatic mutations of LMNB1:

 

Generating mutation plots.

 

Highly correlated genes for LMNB1:

 

Showing top 20/1485 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LMNB1DEPDC1B0.754855707
LMNB1TGFB10.749819303
LMNB1NDC800.74395712012
LMNB1MMS22L0.738523303
LMNB1SPC250.73547412011
LMNB1EME10.733452505
LMNB1NUF20.732939908
LMNB1UCK20.73195303
LMNB1NCAPH0.731219909
LMNB1SPAG50.727411109
LMNB1KIF150.72452812011
LMNB1HJURP0.7244211010
LMNB1CDK10.72352911011
LMNB1DNAJB110.721392505
LMNB1TTK0.71969312010
LMNB1GINS10.71903612011
LMNB1DTL0.71879412012
LMNB1CCNB20.71628511010
LMNB1CEP550.71589112011
LMNB1KIF20A0.71582813011

For details and further investigation, click here