| Full name: thrombospondin 1 | Alias Symbol: TSP1|THBS|TSP|THBS-1|TSP-1 | ||
| Type: protein-coding gene | Cytoband: 15q14 | ||
| Entrez ID: 7057 | HGNC ID: HGNC:11785 | Ensembl Gene: ENSG00000137801 | OMIM ID: 188060 |
| Drug and gene relationship at DGIdb | |||
THBS1 involved pathways:
Expression of THBS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THBS1 | 7057 | 201110_s_at | -0.2306 | 0.8068 | |
| GSE20347 | THBS1 | 7057 | 201110_s_at | 1.8186 | 0.0005 | |
| GSE23400 | THBS1 | 7057 | 201108_s_at | 0.5435 | 0.0011 | |
| GSE26886 | THBS1 | 7057 | 201108_s_at | 1.0359 | 0.0051 | |
| GSE29001 | THBS1 | 7057 | 201108_s_at | 0.2987 | 0.3258 | |
| GSE38129 | THBS1 | 7057 | 201110_s_at | 1.5624 | 0.0005 | |
| GSE45670 | THBS1 | 7057 | 201110_s_at | -0.9052 | 0.1505 | |
| GSE53622 | THBS1 | 7057 | 39446 | 0.4262 | 0.0150 | |
| GSE53624 | THBS1 | 7057 | 39446 | 0.4730 | 0.0000 | |
| GSE63941 | THBS1 | 7057 | 201110_s_at | -3.6512 | 0.0164 | |
| GSE77861 | THBS1 | 7057 | 201108_s_at | 0.2050 | 0.2188 | |
| GSE97050 | THBS1 | 7057 | A_33_P3415820 | 0.4967 | 0.2005 | |
| SRP007169 | THBS1 | 7057 | RNAseq | 4.5279 | 0.0000 | |
| SRP008496 | THBS1 | 7057 | RNAseq | 4.6746 | 0.0000 | |
| SRP064894 | THBS1 | 7057 | RNAseq | -0.1884 | 0.7227 | |
| SRP133303 | THBS1 | 7057 | RNAseq | 0.8603 | 0.0098 | |
| SRP159526 | THBS1 | 7057 | RNAseq | 0.4506 | 0.5396 | |
| SRP193095 | THBS1 | 7057 | RNAseq | 3.0814 | 0.0000 | |
| SRP219564 | THBS1 | 7057 | RNAseq | -0.5133 | 0.5908 | |
| TCGA | THBS1 | 7057 | RNAseq | -0.2722 | 0.0030 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by THBS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THBS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THBS1 | 7057 | 4 | 4 | 22 | |
| GSE20123 | THBS1 | 7057 | 4 | 5 | 21 | |
| GSE43470 | THBS1 | 7057 | 4 | 6 | 33 | |
| GSE46452 | THBS1 | 7057 | 3 | 7 | 49 | |
| GSE47630 | THBS1 | 7057 | 8 | 11 | 21 | |
| GSE54993 | THBS1 | 7057 | 4 | 6 | 60 | |
| GSE54994 | THBS1 | 7057 | 5 | 7 | 41 | |
| GSE60625 | THBS1 | 7057 | 4 | 0 | 7 | |
| GSE74703 | THBS1 | 7057 | 4 | 5 | 27 | |
| GSE74704 | THBS1 | 7057 | 2 | 3 | 15 | |
| TCGA | THBS1 | 7057 | 11 | 17 | 68 |
Total number of gains: 53; Total number of losses: 71; Total Number of normals: 364.
Somatic mutations of THBS1:
Generating mutation plots.
Highly correlated genes for THBS1:
Showing top 20/580 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THBS1 | NNMT | 0.718312 | 4 | 0 | 4 |
| THBS1 | FAP | 0.707374 | 10 | 0 | 10 |
| THBS1 | FBN1 | 0.698903 | 10 | 0 | 10 |
| THBS1 | TNFAIP6 | 0.695066 | 13 | 0 | 12 |
| THBS1 | FSTL1 | 0.688995 | 12 | 0 | 11 |
| THBS1 | FN1 | 0.681218 | 11 | 0 | 10 |
| THBS1 | ITGA5 | 0.679309 | 10 | 0 | 10 |
| THBS1 | ADAMTS15 | 0.677533 | 3 | 0 | 3 |
| THBS1 | MRC1 | 0.676333 | 8 | 0 | 8 |
| THBS1 | MMP2 | 0.672738 | 10 | 0 | 9 |
| THBS1 | C11orf96 | 0.669598 | 5 | 0 | 5 |
| THBS1 | IGFBP7 | 0.668545 | 12 | 0 | 11 |
| THBS1 | MICAL2 | 0.666281 | 8 | 0 | 7 |
| THBS1 | FILIP1L | 0.665039 | 12 | 0 | 12 |
| THBS1 | PMP22 | 0.658953 | 11 | 0 | 9 |
| THBS1 | VCAN | 0.657362 | 12 | 0 | 9 |
| THBS1 | FAM229B | 0.652624 | 3 | 0 | 3 |
| THBS1 | SPATA9 | 0.651831 | 3 | 0 | 3 |
| THBS1 | CHN1 | 0.648954 | 12 | 0 | 10 |
| THBS1 | DACT1 | 0.647778 | 12 | 0 | 10 |
For details and further investigation, click here
