| Full name: T cell leukemia homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q24.31 | ||
| Entrez ID: 3195 | HGNC ID: HGNC:5056 | Ensembl Gene: ENSG00000107807 | OMIM ID: 186770 |
| Drug and gene relationship at DGIdb | |||
Expression of TLX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLX1 | 3195 | 207179_at | 0.0007 | 0.9983 | |
| GSE20347 | TLX1 | 3195 | 207179_at | 0.1391 | 0.2784 | |
| GSE23400 | TLX1 | 3195 | 207179_at | -0.0305 | 0.3904 | |
| GSE26886 | TLX1 | 3195 | 207179_at | 0.0176 | 0.9174 | |
| GSE29001 | TLX1 | 3195 | 207179_at | -0.1497 | 0.2485 | |
| GSE38129 | TLX1 | 3195 | 207179_at | -0.0072 | 0.9668 | |
| GSE45670 | TLX1 | 3195 | 207179_at | 0.0363 | 0.8629 | |
| GSE53622 | TLX1 | 3195 | 28500 | 0.8194 | 0.0000 | |
| GSE53624 | TLX1 | 3195 | 28500 | 0.7521 | 0.0000 | |
| GSE63941 | TLX1 | 3195 | 207179_at | 0.0213 | 0.9326 | |
| GSE77861 | TLX1 | 3195 | 207179_at | -0.0176 | 0.8918 | |
| TCGA | TLX1 | 3195 | RNAseq | 1.7382 | 0.0582 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TLX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLX1 | 3195 | 0 | 9 | 21 | |
| GSE20123 | TLX1 | 3195 | 0 | 8 | 22 | |
| GSE43470 | TLX1 | 3195 | 0 | 8 | 35 | |
| GSE46452 | TLX1 | 3195 | 0 | 11 | 48 | |
| GSE47630 | TLX1 | 3195 | 2 | 14 | 24 | |
| GSE54993 | TLX1 | 3195 | 8 | 0 | 62 | |
| GSE54994 | TLX1 | 3195 | 1 | 12 | 40 | |
| GSE60625 | TLX1 | 3195 | 0 | 0 | 11 | |
| GSE74703 | TLX1 | 3195 | 0 | 5 | 31 | |
| GSE74704 | TLX1 | 3195 | 0 | 4 | 16 | |
| TCGA | TLX1 | 3195 | 5 | 28 | 63 |
Total number of gains: 16; Total number of losses: 99; Total Number of normals: 373.
Somatic mutations of TLX1:
Generating mutation plots.
Highly correlated genes for TLX1:
Showing top 20/134 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLX1 | KHDC3L | 0.665387 | 3 | 0 | 3 |
| TLX1 | ZG16 | 0.658535 | 4 | 0 | 3 |
| TLX1 | IL25 | 0.655402 | 4 | 0 | 4 |
| TLX1 | USHBP1 | 0.650995 | 3 | 0 | 3 |
| TLX1 | APBA1 | 0.625508 | 4 | 0 | 3 |
| TLX1 | L3MBTL1 | 0.617972 | 5 | 0 | 4 |
| TLX1 | RDH8 | 0.616995 | 3 | 0 | 3 |
| TLX1 | SLC22A13 | 0.608896 | 4 | 0 | 3 |
| TLX1 | GPR37L1 | 0.604792 | 5 | 0 | 4 |
| TLX1 | CTRC | 0.596871 | 4 | 0 | 3 |
| TLX1 | AP4S1 | 0.594488 | 4 | 0 | 3 |
| TLX1 | PIK3R5 | 0.589646 | 4 | 0 | 3 |
| TLX1 | BTNL2 | 0.589296 | 5 | 0 | 3 |
| TLX1 | NRG1 | 0.589092 | 4 | 0 | 3 |
| TLX1 | SIK1 | 0.588864 | 3 | 0 | 3 |
| TLX1 | GPR162 | 0.585851 | 4 | 0 | 3 |
| TLX1 | TACR1 | 0.585584 | 3 | 0 | 3 |
| TLX1 | SEMA6C | 0.583974 | 4 | 0 | 3 |
| TLX1 | SH3BP1 | 0.583109 | 5 | 0 | 3 |
| TLX1 | E2F4 | 0.579729 | 4 | 0 | 3 |
For details and further investigation, click here
