| Full name: melanophilin | Alias Symbol: l1Rk3|l(1)-3Rk|Slac-2a|ln|exophilin-3 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 79083 | HGNC ID: HGNC:29643 | Ensembl Gene: ENSG00000115648 | OMIM ID: 606526 |
| Drug and gene relationship at DGIdb | |||
Expression of MLPH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLPH | 79083 | 218211_s_at | -0.4364 | 0.4475 | |
| GSE20347 | MLPH | 79083 | 218211_s_at | -0.1112 | 0.6157 | |
| GSE23400 | MLPH | 79083 | 218211_s_at | -0.4429 | 0.0000 | |
| GSE26886 | MLPH | 79083 | 218211_s_at | 0.3424 | 0.3383 | |
| GSE29001 | MLPH | 79083 | 218211_s_at | -0.2933 | 0.2592 | |
| GSE38129 | MLPH | 79083 | 218211_s_at | -0.3204 | 0.1817 | |
| GSE45670 | MLPH | 79083 | 218211_s_at | -0.2699 | 0.5312 | |
| GSE53622 | MLPH | 79083 | 149371 | -1.2883 | 0.0000 | |
| GSE53624 | MLPH | 79083 | 149371 | -1.5051 | 0.0000 | |
| GSE63941 | MLPH | 79083 | 218211_s_at | -0.4357 | 0.7666 | |
| GSE77861 | MLPH | 79083 | 218211_s_at | 0.4739 | 0.1644 | |
| GSE97050 | MLPH | 79083 | A_23_P165783 | -0.0958 | 0.8584 | |
| SRP064894 | MLPH | 79083 | RNAseq | -0.3976 | 0.3178 | |
| SRP133303 | MLPH | 79083 | RNAseq | -0.9664 | 0.0516 | |
| SRP159526 | MLPH | 79083 | RNAseq | -0.6219 | 0.3994 | |
| SRP193095 | MLPH | 79083 | RNAseq | -0.9823 | 0.0653 | |
| SRP219564 | MLPH | 79083 | RNAseq | 0.9331 | 0.1633 | |
| TCGA | MLPH | 79083 | RNAseq | -1.3074 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MLPH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLPH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLPH | 79083 | 1 | 12 | 17 | |
| GSE20123 | MLPH | 79083 | 1 | 12 | 17 | |
| GSE43470 | MLPH | 79083 | 1 | 9 | 33 | |
| GSE46452 | MLPH | 79083 | 0 | 5 | 54 | |
| GSE47630 | MLPH | 79083 | 4 | 5 | 31 | |
| GSE54993 | MLPH | 79083 | 3 | 2 | 65 | |
| GSE54994 | MLPH | 79083 | 8 | 10 | 35 | |
| GSE60625 | MLPH | 79083 | 0 | 3 | 8 | |
| GSE74703 | MLPH | 79083 | 1 | 7 | 28 | |
| GSE74704 | MLPH | 79083 | 1 | 5 | 14 | |
| TCGA | MLPH | 79083 | 11 | 27 | 58 |
Total number of gains: 31; Total number of losses: 97; Total Number of normals: 360.
Somatic mutations of MLPH:
Generating mutation plots.
Highly correlated genes for MLPH:
Showing top 20/71 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLPH | TOX3 | 0.665751 | 7 | 0 | 7 |
| MLPH | CHRM3 | 0.649299 | 3 | 0 | 3 |
| MLPH | EYA1 | 0.635819 | 4 | 0 | 3 |
| MLPH | CHRM1 | 0.631608 | 5 | 0 | 4 |
| MLPH | GRIA2 | 0.627602 | 4 | 0 | 4 |
| MLPH | TSPAN8 | 0.623955 | 10 | 0 | 9 |
| MLPH | AGR3 | 0.616535 | 6 | 0 | 5 |
| MLPH | TMC5 | 0.593743 | 6 | 0 | 5 |
| MLPH | SHANK2 | 0.593288 | 4 | 0 | 3 |
| MLPH | TSPAN12 | 0.592473 | 5 | 0 | 4 |
| MLPH | CTTN | 0.590118 | 4 | 0 | 3 |
| MLPH | CHST9 | 0.580893 | 6 | 0 | 4 |
| MLPH | SLC44A4 | 0.580149 | 8 | 0 | 6 |
| MLPH | CAPN8 | 0.574608 | 5 | 0 | 4 |
| MLPH | SH3KBP1 | 0.57436 | 3 | 0 | 3 |
| MLPH | AZGP1 | 0.573103 | 9 | 0 | 6 |
| MLPH | NXPE4 | 0.571551 | 6 | 0 | 5 |
| MLPH | TMEM74B | 0.566 | 3 | 0 | 3 |
| MLPH | MANSC1 | 0.56446 | 5 | 0 | 4 |
| MLPH | SCGB2A1 | 0.556634 | 7 | 0 | 4 |
For details and further investigation, click here
