| Full name: transmembrane protein 74 | Alias Symbol: FLJ30668|NET36 | ||
| Type: protein-coding gene | Cytoband: 8q23.1 | ||
| Entrez ID: 157753 | HGNC ID: HGNC:26409 | Ensembl Gene: ENSG00000164841 | OMIM ID: 613935 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM74:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM74 | 157753 | 1552520_at | -0.2351 | 0.4067 | |
| GSE26886 | TMEM74 | 157753 | 1552520_at | -0.6087 | 0.0002 | |
| GSE45670 | TMEM74 | 157753 | 1552520_at | -0.2480 | 0.0139 | |
| GSE53622 | TMEM74 | 157753 | 35995 | -2.3196 | 0.0000 | |
| GSE53624 | TMEM74 | 157753 | 35995 | -2.0051 | 0.0000 | |
| GSE63941 | TMEM74 | 157753 | 1552520_at | 0.0767 | 0.8331 | |
| GSE77861 | TMEM74 | 157753 | 1555159_at | 0.0460 | 0.6375 | |
| SRP064894 | TMEM74 | 157753 | RNAseq | -1.8555 | 0.0000 | |
| SRP133303 | TMEM74 | 157753 | RNAseq | -1.6152 | 0.0009 | |
| SRP159526 | TMEM74 | 157753 | RNAseq | -1.1847 | 0.0564 | |
| SRP219564 | TMEM74 | 157753 | RNAseq | -2.8403 | 0.0000 | |
| TCGA | TMEM74 | 157753 | RNAseq | -0.4597 | 0.3182 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TMEM74 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM74:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM74 | 157753 | 16 | 0 | 14 | |
| GSE20123 | TMEM74 | 157753 | 17 | 0 | 13 | |
| GSE43470 | TMEM74 | 157753 | 23 | 0 | 20 | |
| GSE46452 | TMEM74 | 157753 | 25 | 0 | 34 | |
| GSE47630 | TMEM74 | 157753 | 24 | 0 | 16 | |
| GSE54993 | TMEM74 | 157753 | 0 | 20 | 50 | |
| GSE54994 | TMEM74 | 157753 | 37 | 1 | 15 | |
| GSE60625 | TMEM74 | 157753 | 0 | 4 | 7 | |
| GSE74703 | TMEM74 | 157753 | 20 | 0 | 16 | |
| GSE74704 | TMEM74 | 157753 | 11 | 0 | 9 | |
| TCGA | TMEM74 | 157753 | 60 | 1 | 35 |
Total number of gains: 233; Total number of losses: 26; Total Number of normals: 229.
Somatic mutations of TMEM74:
Generating mutation plots.
Highly correlated genes for TMEM74:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM74 | KCNB1 | 0.713596 | 3 | 0 | 3 |
| TMEM74 | SH3BGR | 0.703868 | 3 | 0 | 3 |
| TMEM74 | SORCS1 | 0.697311 | 3 | 0 | 3 |
| TMEM74 | XKR4 | 0.682453 | 4 | 0 | 4 |
| TMEM74 | LDB3 | 0.679659 | 3 | 0 | 3 |
| TMEM74 | SLC27A6 | 0.675722 | 5 | 0 | 4 |
| TMEM74 | CAP2 | 0.675572 | 3 | 0 | 3 |
| TMEM74 | GNA14 | 0.672971 | 4 | 0 | 4 |
| TMEM74 | TEAD1 | 0.663741 | 4 | 0 | 4 |
| TMEM74 | ARHGAP6 | 0.661611 | 4 | 0 | 3 |
| TMEM74 | STX7 | 0.660608 | 5 | 0 | 5 |
| TMEM74 | ADAMTSL3 | 0.659829 | 3 | 0 | 3 |
| TMEM74 | PRKAA2 | 0.659607 | 4 | 0 | 4 |
| TMEM74 | PDK4 | 0.656456 | 4 | 0 | 4 |
| TMEM74 | CRYZL1 | 0.655517 | 4 | 0 | 4 |
| TMEM74 | ANGPTL1 | 0.655396 | 4 | 0 | 3 |
| TMEM74 | ALDH1A2 | 0.654595 | 4 | 0 | 4 |
| TMEM74 | CASQ2 | 0.652101 | 4 | 0 | 3 |
| TMEM74 | CITED2 | 0.652009 | 5 | 0 | 4 |
| TMEM74 | ZNF471 | 0.651902 | 5 | 0 | 4 |
For details and further investigation, click here
