| Full name: STT3 oligosaccharyltransferase complex catalytic subunit A | Alias Symbol: TMC|MGC9042|STT3-A | ||
| Type: protein-coding gene | Cytoband: 11q24.2 | ||
| Entrez ID: 3703 | HGNC ID: HGNC:6172 | Ensembl Gene: ENSG00000134910 | OMIM ID: 601134 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of STT3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STT3A | 3703 | 202223_at | 0.4458 | 0.3088 | |
| GSE20347 | STT3A | 3703 | 202223_at | 0.0628 | 0.6533 | |
| GSE23400 | STT3A | 3703 | 202223_at | 0.2463 | 0.0027 | |
| GSE26886 | STT3A | 3703 | 202223_at | -1.0602 | 0.0000 | |
| GSE29001 | STT3A | 3703 | 202223_at | -0.1929 | 0.5085 | |
| GSE38129 | STT3A | 3703 | 202223_at | 0.3658 | 0.0936 | |
| GSE45670 | STT3A | 3703 | 202223_at | 0.4339 | 0.0060 | |
| GSE53622 | STT3A | 3703 | 2637 | 0.3200 | 0.0000 | |
| GSE53624 | STT3A | 3703 | 2637 | 0.2979 | 0.0002 | |
| GSE63941 | STT3A | 3703 | 202223_at | -1.3074 | 0.0109 | |
| GSE77861 | STT3A | 3703 | 202223_at | 0.1886 | 0.3895 | |
| GSE97050 | STT3A | 3703 | A_23_P104734 | 0.1608 | 0.5843 | |
| SRP007169 | STT3A | 3703 | RNAseq | 0.6914 | 0.0901 | |
| SRP008496 | STT3A | 3703 | RNAseq | 0.7397 | 0.0006 | |
| SRP064894 | STT3A | 3703 | RNAseq | 0.4947 | 0.0000 | |
| SRP133303 | STT3A | 3703 | RNAseq | 0.3608 | 0.0546 | |
| SRP159526 | STT3A | 3703 | RNAseq | 0.1884 | 0.4802 | |
| SRP193095 | STT3A | 3703 | RNAseq | -0.1429 | 0.2900 | |
| SRP219564 | STT3A | 3703 | RNAseq | 0.4283 | 0.0257 | |
| TCGA | STT3A | 3703 | RNAseq | -0.0199 | 0.6626 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by STT3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STT3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STT3A | 3703 | 0 | 13 | 17 | |
| GSE20123 | STT3A | 3703 | 0 | 13 | 17 | |
| GSE43470 | STT3A | 3703 | 2 | 7 | 34 | |
| GSE46452 | STT3A | 3703 | 3 | 26 | 30 | |
| GSE47630 | STT3A | 3703 | 2 | 19 | 19 | |
| GSE54993 | STT3A | 3703 | 10 | 0 | 60 | |
| GSE54994 | STT3A | 3703 | 5 | 19 | 29 | |
| GSE60625 | STT3A | 3703 | 0 | 3 | 8 | |
| GSE74703 | STT3A | 3703 | 1 | 5 | 30 | |
| GSE74704 | STT3A | 3703 | 0 | 9 | 11 | |
| TCGA | STT3A | 3703 | 7 | 50 | 39 |
Total number of gains: 30; Total number of losses: 164; Total Number of normals: 294.
Somatic mutations of STT3A:
Generating mutation plots.
Highly correlated genes for STT3A:
Showing top 20/324 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STT3A | PPP1R3D | 0.711207 | 3 | 0 | 3 |
| STT3A | PCYT1A | 0.702244 | 3 | 0 | 3 |
| STT3A | MCOLN1 | 0.695037 | 3 | 0 | 3 |
| STT3A | LAMP2 | 0.693424 | 3 | 0 | 3 |
| STT3A | PHF6 | 0.662867 | 3 | 0 | 3 |
| STT3A | TMPRSS13 | 0.653876 | 3 | 0 | 3 |
| STT3A | FAM118B | 0.649924 | 7 | 0 | 6 |
| STT3A | ALKBH8 | 0.647292 | 3 | 0 | 3 |
| STT3A | APH1A | 0.645384 | 4 | 0 | 4 |
| STT3A | RNF26 | 0.641711 | 5 | 0 | 5 |
| STT3A | PDIA5 | 0.639035 | 4 | 0 | 3 |
| STT3A | SH3RF3-AS1 | 0.637475 | 3 | 0 | 3 |
| STT3A | HYLS1 | 0.636803 | 7 | 0 | 6 |
| STT3A | ROBO1 | 0.634228 | 3 | 0 | 3 |
| STT3A | NLRX1 | 0.634147 | 3 | 0 | 3 |
| STT3A | SLC39A7 | 0.634083 | 9 | 0 | 7 |
| STT3A | KCNK6 | 0.633716 | 3 | 0 | 3 |
| STT3A | KDSR | 0.633565 | 4 | 0 | 4 |
| STT3A | REXO2 | 0.633311 | 4 | 0 | 4 |
| STT3A | LYSMD3 | 0.633241 | 3 | 0 | 3 |
For details and further investigation, click here
