| Full name: sphingomyelin phosphodiesterase acid like 3A | Alias Symbol: FLJ20177|ASM3A|ASML3a|yR36GH4.1 | ||
| Type: protein-coding gene | Cytoband: 6q22.31 | ||
| Entrez ID: 10924 | HGNC ID: HGNC:17389 | Ensembl Gene: ENSG00000172594 | OMIM ID: 610728 |
| Drug and gene relationship at DGIdb | |||
Expression of SMPDL3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMPDL3A | 10924 | 213624_at | -0.4519 | 0.6078 | |
| GSE20347 | SMPDL3A | 10924 | 213624_at | -1.3352 | 0.0000 | |
| GSE23400 | SMPDL3A | 10924 | 213624_at | -0.3427 | 0.0016 | |
| GSE26886 | SMPDL3A | 10924 | 213624_at | -1.5412 | 0.0001 | |
| GSE29001 | SMPDL3A | 10924 | 213624_at | -0.4225 | 0.3587 | |
| GSE38129 | SMPDL3A | 10924 | 213624_at | -0.9273 | 0.0001 | |
| GSE45670 | SMPDL3A | 10924 | 213624_at | -0.1416 | 0.6259 | |
| GSE53622 | SMPDL3A | 10924 | 17291 | -0.7270 | 0.0000 | |
| GSE53624 | SMPDL3A | 10924 | 17291 | -0.8850 | 0.0000 | |
| GSE63941 | SMPDL3A | 10924 | 213624_at | -5.1526 | 0.0000 | |
| GSE77861 | SMPDL3A | 10924 | 213624_at | -0.6292 | 0.0712 | |
| GSE97050 | SMPDL3A | 10924 | A_23_P72117 | 0.0625 | 0.8218 | |
| SRP007169 | SMPDL3A | 10924 | RNAseq | -1.6069 | 0.0008 | |
| SRP008496 | SMPDL3A | 10924 | RNAseq | -1.8325 | 0.0000 | |
| SRP064894 | SMPDL3A | 10924 | RNAseq | -0.1556 | 0.5655 | |
| SRP133303 | SMPDL3A | 10924 | RNAseq | -0.5765 | 0.0667 | |
| SRP159526 | SMPDL3A | 10924 | RNAseq | -0.7501 | 0.1719 | |
| SRP193095 | SMPDL3A | 10924 | RNAseq | -1.6028 | 0.0000 | |
| SRP219564 | SMPDL3A | 10924 | RNAseq | -0.3121 | 0.4069 | |
| TCGA | SMPDL3A | 10924 | RNAseq | -0.3884 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SMPDL3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMPDL3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMPDL3A | 10924 | 1 | 4 | 25 | |
| GSE20123 | SMPDL3A | 10924 | 1 | 3 | 26 | |
| GSE43470 | SMPDL3A | 10924 | 5 | 1 | 37 | |
| GSE46452 | SMPDL3A | 10924 | 2 | 11 | 46 | |
| GSE47630 | SMPDL3A | 10924 | 9 | 4 | 27 | |
| GSE54993 | SMPDL3A | 10924 | 3 | 2 | 65 | |
| GSE54994 | SMPDL3A | 10924 | 8 | 8 | 37 | |
| GSE60625 | SMPDL3A | 10924 | 0 | 1 | 10 | |
| GSE74703 | SMPDL3A | 10924 | 4 | 1 | 31 | |
| GSE74704 | SMPDL3A | 10924 | 0 | 1 | 19 | |
| TCGA | SMPDL3A | 10924 | 11 | 19 | 66 |
Total number of gains: 44; Total number of losses: 55; Total Number of normals: 389.
Somatic mutations of SMPDL3A:
Generating mutation plots.
Highly correlated genes for SMPDL3A:
Showing top 20/484 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMPDL3A | PGM2 | 0.666475 | 8 | 0 | 8 |
| SMPDL3A | LRRC66 | 0.647054 | 3 | 0 | 3 |
| SMPDL3A | SMIM15 | 0.643695 | 5 | 0 | 4 |
| SMPDL3A | TMPRSS13 | 0.643502 | 3 | 0 | 3 |
| SMPDL3A | SMPD1 | 0.643329 | 5 | 0 | 4 |
| SMPDL3A | RHD | 0.631779 | 3 | 0 | 3 |
| SMPDL3A | KCTD10 | 0.629943 | 3 | 0 | 3 |
| SMPDL3A | CARD6 | 0.620693 | 7 | 0 | 6 |
| SMPDL3A | SH3PXD2A-AS1 | 0.619856 | 3 | 0 | 3 |
| SMPDL3A | ACTR3C | 0.615023 | 3 | 0 | 3 |
| SMPDL3A | SMIM14 | 0.6087 | 7 | 0 | 6 |
| SMPDL3A | GSKIP | 0.607546 | 7 | 0 | 5 |
| SMPDL3A | EMC3 | 0.606046 | 8 | 0 | 7 |
| SMPDL3A | TMEM9B | 0.602484 | 10 | 0 | 6 |
| SMPDL3A | KCNJ2-AS1 | 0.599758 | 3 | 0 | 3 |
| SMPDL3A | SCP2 | 0.598523 | 11 | 0 | 9 |
| SMPDL3A | CYP2C18 | 0.598496 | 7 | 0 | 6 |
| SMPDL3A | STX12 | 0.596361 | 11 | 0 | 9 |
| SMPDL3A | CPEB4 | 0.595044 | 8 | 0 | 6 |
| SMPDL3A | KCNK6 | 0.595037 | 8 | 0 | 6 |
For details and further investigation, click here
