| Full name: C-C motif chemokine ligand 21 | Alias Symbol: SLC|exodus-2|TCA4|CKb9|6Ckine|ECL | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 6366 | HGNC ID: HGNC:10620 | Ensembl Gene: ENSG00000137077 | OMIM ID: 602737 |
| Drug and gene relationship at DGIdb | |||
CCL21 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04064 | NF-kappa B signaling pathway |
Expression of CCL21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL21 | 6366 | 204606_at | -1.0525 | 0.2444 | |
| GSE20347 | CCL21 | 6366 | 204606_at | 0.0289 | 0.8746 | |
| GSE23400 | CCL21 | 6366 | 204606_at | -0.1943 | 0.0222 | |
| GSE26886 | CCL21 | 6366 | 204606_at | 0.3993 | 0.0609 | |
| GSE29001 | CCL21 | 6366 | 204606_at | -0.0532 | 0.7597 | |
| GSE38129 | CCL21 | 6366 | 204606_at | -0.5486 | 0.2503 | |
| GSE45670 | CCL21 | 6366 | 204606_at | -0.7784 | 0.0178 | |
| GSE53622 | CCL21 | 6366 | 107717 | -1.3342 | 0.0000 | |
| GSE53624 | CCL21 | 6366 | 107717 | -0.9516 | 0.0000 | |
| GSE63941 | CCL21 | 6366 | 204606_at | 0.3068 | 0.0413 | |
| GSE77861 | CCL21 | 6366 | 204606_at | -0.0394 | 0.7690 | |
| GSE97050 | CCL21 | 6366 | A_33_P3273623 | 0.7523 | 0.2371 | |
| SRP007169 | CCL21 | 6366 | RNAseq | 2.8263 | 0.0000 | |
| SRP008496 | CCL21 | 6366 | RNAseq | 2.3537 | 0.0001 | |
| SRP064894 | CCL21 | 6366 | RNAseq | -0.6446 | 0.1552 | |
| SRP133303 | CCL21 | 6366 | RNAseq | -1.1439 | 0.0172 | |
| SRP159526 | CCL21 | 6366 | RNAseq | -1.4799 | 0.0239 | |
| SRP219564 | CCL21 | 6366 | RNAseq | -0.9218 | 0.2567 | |
| TCGA | CCL21 | 6366 | RNAseq | -0.4476 | 0.0376 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by CCL21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL21 | 6366 | 4 | 13 | 13 | |
| GSE20123 | CCL21 | 6366 | 4 | 13 | 13 | |
| GSE43470 | CCL21 | 6366 | 3 | 10 | 30 | |
| GSE46452 | CCL21 | 6366 | 6 | 15 | 38 | |
| GSE47630 | CCL21 | 6366 | 1 | 20 | 19 | |
| GSE54993 | CCL21 | 6366 | 6 | 0 | 64 | |
| GSE54994 | CCL21 | 6366 | 6 | 12 | 35 | |
| GSE60625 | CCL21 | 6366 | 0 | 0 | 11 | |
| GSE74703 | CCL21 | 6366 | 2 | 7 | 27 | |
| GSE74704 | CCL21 | 6366 | 0 | 11 | 9 | |
| TCGA | CCL21 | 6366 | 16 | 44 | 36 |
Total number of gains: 48; Total number of losses: 145; Total Number of normals: 295.
Somatic mutations of CCL21:
Generating mutation plots.
Highly correlated genes for CCL21:
Showing top 20/439 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL21 | TPP1 | 0.813593 | 3 | 0 | 3 |
| CCL21 | C16orf86 | 0.753839 | 3 | 0 | 3 |
| CCL21 | ST8SIA4 | 0.735648 | 3 | 0 | 3 |
| CCL21 | GIMAP7 | 0.729645 | 5 | 0 | 5 |
| CCL21 | GIMAP5 | 0.715911 | 3 | 0 | 3 |
| CCL21 | PLXND1 | 0.714162 | 4 | 0 | 3 |
| CCL21 | COL18A1-AS1 | 0.713481 | 3 | 0 | 3 |
| CCL21 | GIMAP6 | 0.711369 | 7 | 0 | 6 |
| CCL21 | A2M | 0.700526 | 9 | 0 | 8 |
| CCL21 | AXL | 0.695684 | 7 | 0 | 6 |
| CCL21 | RASGRP3 | 0.688453 | 5 | 0 | 5 |
| CCL21 | ZNF579 | 0.685987 | 3 | 0 | 3 |
| CCL21 | GIMAP8 | 0.682778 | 5 | 0 | 5 |
| CCL21 | MSC | 0.6812 | 3 | 0 | 3 |
| CCL21 | CLEC14A | 0.679719 | 7 | 0 | 7 |
| CCL21 | PMP22 | 0.678763 | 9 | 0 | 8 |
| CCL21 | XAB2 | 0.674284 | 3 | 0 | 3 |
| CCL21 | ZNF609 | 0.66851 | 3 | 0 | 3 |
| CCL21 | DCTN3 | 0.667979 | 4 | 0 | 4 |
| CCL21 | GAB3 | 0.666087 | 5 | 0 | 5 |
For details and further investigation, click here
