| Full name: tetratricopeptide repeat domain 5 | Alias Symbol: Strap | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 91875 | HGNC ID: HGNC:19274 | Ensembl Gene: ENSG00000136319 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TTC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC5 | 91875 | 226557_at | 0.3757 | 0.2666 | |
| GSE26886 | TTC5 | 91875 | 226557_at | -0.2628 | 0.2526 | |
| GSE45670 | TTC5 | 91875 | 226557_at | 0.3603 | 0.0377 | |
| GSE53622 | TTC5 | 91875 | 87239 | 0.4942 | 0.0000 | |
| GSE53624 | TTC5 | 91875 | 87239 | 0.6229 | 0.0000 | |
| GSE63941 | TTC5 | 91875 | 226557_at | 0.9173 | 0.1814 | |
| GSE77861 | TTC5 | 91875 | 226557_at | 0.9656 | 0.0482 | |
| GSE97050 | TTC5 | 91875 | A_33_P3347108 | 0.0071 | 0.9816 | |
| SRP007169 | TTC5 | 91875 | RNAseq | 0.9316 | 0.0074 | |
| SRP008496 | TTC5 | 91875 | RNAseq | 1.0454 | 0.0000 | |
| SRP064894 | TTC5 | 91875 | RNAseq | 0.5596 | 0.0016 | |
| SRP133303 | TTC5 | 91875 | RNAseq | 0.3517 | 0.0823 | |
| SRP159526 | TTC5 | 91875 | RNAseq | 0.9159 | 0.0000 | |
| SRP193095 | TTC5 | 91875 | RNAseq | 0.4954 | 0.0000 | |
| SRP219564 | TTC5 | 91875 | RNAseq | 0.7898 | 0.0200 | |
| TCGA | TTC5 | 91875 | RNAseq | 0.2384 | 0.0008 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TTC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC5 | 91875 | 11 | 3 | 16 | |
| GSE20123 | TTC5 | 91875 | 9 | 3 | 18 | |
| GSE43470 | TTC5 | 91875 | 7 | 1 | 35 | |
| GSE46452 | TTC5 | 91875 | 19 | 2 | 38 | |
| GSE47630 | TTC5 | 91875 | 10 | 10 | 20 | |
| GSE54993 | TTC5 | 91875 | 3 | 11 | 56 | |
| GSE54994 | TTC5 | 91875 | 18 | 5 | 30 | |
| GSE60625 | TTC5 | 91875 | 0 | 2 | 9 | |
| GSE74703 | TTC5 | 91875 | 6 | 1 | 29 | |
| GSE74704 | TTC5 | 91875 | 4 | 2 | 14 | |
| TCGA | TTC5 | 91875 | 28 | 16 | 52 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of TTC5:
Generating mutation plots.
Highly correlated genes for TTC5:
Showing top 20/70 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC5 | LTB4R | 0.692832 | 3 | 0 | 3 |
| TTC5 | TCHH | 0.678345 | 4 | 0 | 3 |
| TTC5 | C14orf119 | 0.675954 | 4 | 0 | 3 |
| TTC5 | NPAS1 | 0.665734 | 3 | 0 | 3 |
| TTC5 | ELOVL3 | 0.64717 | 4 | 0 | 4 |
| TTC5 | PSMB5 | 0.640025 | 9 | 0 | 6 |
| TTC5 | TRIM16 | 0.638928 | 3 | 0 | 3 |
| TTC5 | TMCC2 | 0.617664 | 4 | 0 | 3 |
| TTC5 | OSBPL11 | 0.617508 | 3 | 0 | 3 |
| TTC5 | ST8SIA1 | 0.603667 | 3 | 0 | 3 |
| TTC5 | GPRIN1 | 0.596406 | 5 | 0 | 3 |
| TTC5 | TMEM9 | 0.583856 | 6 | 0 | 4 |
| TTC5 | CCDC43 | 0.580751 | 5 | 0 | 3 |
| TTC5 | EPB41L4B | 0.57548 | 4 | 0 | 3 |
| TTC5 | NAT14 | 0.573848 | 6 | 0 | 4 |
| TTC5 | TMEM251 | 0.571435 | 5 | 0 | 3 |
| TTC5 | SALL4 | 0.570826 | 7 | 0 | 5 |
| TTC5 | NDUFAF7 | 0.569213 | 4 | 0 | 3 |
| TTC5 | DIAPH3 | 0.566779 | 4 | 0 | 3 |
| TTC5 | GALNS | 0.564381 | 6 | 0 | 3 |
For details and further investigation, click here
