| Full name: lin-54 DREAM MuvB core complex component | Alias Symbol: MIP120|DKFZp686L1814|JC8.6|CXCDC1|TCX1 | ||
| Type: protein-coding gene | Cytoband: 4q21.22 | ||
| Entrez ID: 132660 | HGNC ID: HGNC:25397 | Ensembl Gene: ENSG00000189308 | OMIM ID: 613367 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LIN54:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN54 | 132660 | 235809_at | -0.0956 | 0.9093 | |
| GSE26886 | LIN54 | 132660 | 235809_at | -0.0056 | 0.9795 | |
| GSE45670 | LIN54 | 132660 | 235809_at | -0.3084 | 0.0031 | |
| GSE53622 | LIN54 | 132660 | 70873 | -0.5230 | 0.0000 | |
| GSE53624 | LIN54 | 132660 | 70873 | -0.7926 | 0.0000 | |
| GSE63941 | LIN54 | 132660 | 235809_at | 0.1257 | 0.6502 | |
| GSE77861 | LIN54 | 132660 | 235809_at | -0.0451 | 0.6295 | |
| GSE97050 | LIN54 | 132660 | A_33_P3851513 | -0.0967 | 0.7083 | |
| SRP007169 | LIN54 | 132660 | RNAseq | -1.4237 | 0.0002 | |
| SRP008496 | LIN54 | 132660 | RNAseq | -1.6201 | 0.0000 | |
| SRP064894 | LIN54 | 132660 | RNAseq | -1.3005 | 0.0000 | |
| SRP133303 | LIN54 | 132660 | RNAseq | -0.1462 | 0.3896 | |
| SRP159526 | LIN54 | 132660 | RNAseq | -0.8264 | 0.0001 | |
| SRP193095 | LIN54 | 132660 | RNAseq | -0.6760 | 0.0000 | |
| SRP219564 | LIN54 | 132660 | RNAseq | -0.9720 | 0.0347 | |
| TCGA | LIN54 | 132660 | RNAseq | 0.1053 | 0.0667 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by LIN54 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIN54:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN54 | 132660 | 2 | 11 | 17 | |
| GSE20123 | LIN54 | 132660 | 2 | 11 | 17 | |
| GSE43470 | LIN54 | 132660 | 0 | 13 | 30 | |
| GSE46452 | LIN54 | 132660 | 1 | 36 | 22 | |
| GSE47630 | LIN54 | 132660 | 0 | 20 | 20 | |
| GSE54993 | LIN54 | 132660 | 8 | 0 | 62 | |
| GSE54994 | LIN54 | 132660 | 1 | 9 | 43 | |
| GSE60625 | LIN54 | 132660 | 0 | 0 | 11 | |
| GSE74703 | LIN54 | 132660 | 0 | 11 | 25 | |
| GSE74704 | LIN54 | 132660 | 1 | 6 | 13 | |
| TCGA | LIN54 | 132660 | 13 | 34 | 49 |
Total number of gains: 28; Total number of losses: 151; Total Number of normals: 309.
Somatic mutations of LIN54:
Generating mutation plots.
Highly correlated genes for LIN54:
Showing top 20/698 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN54 | TEAD3 | 0.75951 | 3 | 0 | 3 |
| LIN54 | TWF1 | 0.74824 | 4 | 0 | 4 |
| LIN54 | CA13 | 0.713085 | 3 | 0 | 3 |
| LIN54 | SCYL2 | 0.709763 | 3 | 0 | 3 |
| LIN54 | SLC10A5 | 0.705939 | 3 | 0 | 3 |
| LIN54 | PAQR8 | 0.699589 | 4 | 0 | 4 |
| LIN54 | GSKIP | 0.697737 | 3 | 0 | 3 |
| LIN54 | ARPC5L | 0.689923 | 3 | 0 | 3 |
| LIN54 | ALDH3A2 | 0.683603 | 4 | 0 | 4 |
| LIN54 | SAMD5 | 0.682352 | 4 | 0 | 4 |
| LIN54 | CCNG2 | 0.676112 | 5 | 0 | 5 |
| LIN54 | CASC3 | 0.673781 | 3 | 0 | 3 |
| LIN54 | VAMP8 | 0.670059 | 3 | 0 | 3 |
| LIN54 | PPP4R2 | 0.668517 | 4 | 0 | 3 |
| LIN54 | LGI1 | 0.667364 | 4 | 0 | 4 |
| LIN54 | ABCA5 | 0.66681 | 4 | 0 | 4 |
| LIN54 | OSTF1 | 0.659202 | 5 | 0 | 5 |
| LIN54 | UNC5CL | 0.658853 | 3 | 0 | 3 |
| LIN54 | RALGPS2 | 0.65851 | 5 | 0 | 4 |
| LIN54 | TTC9 | 0.657705 | 5 | 0 | 5 |
For details and further investigation, click here
