| Full name: tRNA-yW synthesizing protein 1 homolog | Alias Symbol: FLJ10900|MGC23001|MGC60291|YPL207W|TYW1A | ||
| Type: protein-coding gene | Cytoband: 7q11.21 | ||
| Entrez ID: 55253 | HGNC ID: HGNC:25598 | Ensembl Gene: ENSG00000198874 | OMIM ID: 611243 |
| Drug and gene relationship at DGIdb | |||
Expression of TYW1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TYW1 | 55253 | 218347_at | 0.3472 | 0.4630 | |
| GSE20347 | TYW1 | 55253 | 218347_at | 0.4277 | 0.0037 | |
| GSE23400 | TYW1 | 55253 | 218347_at | 0.1664 | 0.0004 | |
| GSE26886 | TYW1 | 55253 | 218347_at | -0.2316 | 0.4542 | |
| GSE29001 | TYW1 | 55253 | 218347_at | 0.1708 | 0.5831 | |
| GSE38129 | TYW1 | 55253 | 218347_at | 0.4662 | 0.0001 | |
| GSE45670 | TYW1 | 55253 | 218347_at | 0.1991 | 0.1920 | |
| GSE53622 | TYW1 | 55253 | 36837 | 0.1807 | 0.0094 | |
| GSE53624 | TYW1 | 55253 | 36837 | 0.3028 | 0.0000 | |
| GSE63941 | TYW1 | 55253 | 218347_at | -0.1524 | 0.7497 | |
| GSE77861 | TYW1 | 55253 | 218347_at | 0.1152 | 0.5741 | |
| GSE97050 | TYW1 | 55253 | A_32_P52206 | 0.2771 | 0.2616 | |
| SRP007169 | TYW1 | 55253 | RNAseq | 1.2012 | 0.0075 | |
| SRP008496 | TYW1 | 55253 | RNAseq | 1.4101 | 0.0000 | |
| SRP064894 | TYW1 | 55253 | RNAseq | 0.3175 | 0.0012 | |
| SRP133303 | TYW1 | 55253 | RNAseq | 0.2267 | 0.0171 | |
| SRP159526 | TYW1 | 55253 | RNAseq | 0.4182 | 0.0333 | |
| SRP193095 | TYW1 | 55253 | RNAseq | 0.4205 | 0.0001 | |
| SRP219564 | TYW1 | 55253 | RNAseq | 0.4015 | 0.2080 | |
| TCGA | TYW1 | 55253 | RNAseq | 0.0425 | 0.4462 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TYW1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TYW1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TYW1 | 55253 | 11 | 2 | 17 | |
| GSE20123 | TYW1 | 55253 | 10 | 2 | 18 | |
| GSE43470 | TYW1 | 55253 | 3 | 1 | 39 | |
| GSE46452 | TYW1 | 55253 | 13 | 0 | 46 | |
| GSE47630 | TYW1 | 55253 | 7 | 1 | 32 | |
| GSE54993 | TYW1 | 55253 | 2 | 7 | 61 | |
| GSE54994 | TYW1 | 55253 | 11 | 4 | 38 | |
| GSE60625 | TYW1 | 55253 | 0 | 0 | 11 | |
| GSE74703 | TYW1 | 55253 | 3 | 1 | 32 | |
| GSE74704 | TYW1 | 55253 | 5 | 1 | 14 | |
| TCGA | TYW1 | 55253 | 46 | 6 | 44 |
Total number of gains: 111; Total number of losses: 25; Total Number of normals: 352.
Somatic mutations of TYW1:
Generating mutation plots.
Highly correlated genes for TYW1:
Showing top 20/612 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TYW1 | EP400 | 0.813144 | 3 | 0 | 3 |
| TYW1 | MLLT1 | 0.805482 | 3 | 0 | 3 |
| TYW1 | ERP27 | 0.773741 | 3 | 0 | 3 |
| TYW1 | TMEM115 | 0.771304 | 3 | 0 | 3 |
| TYW1 | SP3 | 0.74602 | 3 | 0 | 3 |
| TYW1 | KLHL24 | 0.736984 | 3 | 0 | 3 |
| TYW1 | TMEM216 | 0.730403 | 3 | 0 | 3 |
| TYW1 | PIGM | 0.729637 | 3 | 0 | 3 |
| TYW1 | NFE2L1 | 0.715217 | 3 | 0 | 3 |
| TYW1 | LARP4 | 0.715181 | 4 | 0 | 3 |
| TYW1 | PPP1R35 | 0.714341 | 3 | 0 | 3 |
| TYW1 | EIF3C | 0.705137 | 3 | 0 | 3 |
| TYW1 | THADA | 0.697889 | 4 | 0 | 4 |
| TYW1 | RBAK | 0.697479 | 3 | 0 | 3 |
| TYW1 | SIX4 | 0.696689 | 3 | 0 | 3 |
| TYW1 | SCYL3 | 0.696097 | 3 | 0 | 3 |
| TYW1 | C10orf88 | 0.696085 | 4 | 0 | 3 |
| TYW1 | ZNF668 | 0.693658 | 4 | 0 | 3 |
| TYW1 | POGLUT1 | 0.693218 | 5 | 0 | 4 |
| TYW1 | TUBA1B | 0.686235 | 5 | 0 | 5 |
For details and further investigation, click here
