SAFB

 

Full name: scaffold attachment factor B Alias Symbol: HET|SAFB1
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 6294 HGNC ID: HGNC:10520 Ensembl Gene: ENSG00000160633 OMIM ID: 602895
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of SAFB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SAFB 6294 201748_s_at 0.4702 0.0927
GSE20347 SAFB 6294 201748_s_at 0.5119 0.0000
GSE23400 SAFB 6294 201748_s_at 0.3793 0.0000
GSE26886 SAFB 6294 201748_s_at -0.1460 0.3663
GSE29001 SAFB 6294 201748_s_at 0.2027 0.5586
GSE38129 SAFB 6294 201748_s_at 0.4388 0.0001
GSE45670 SAFB 6294 201748_s_at 0.2273 0.0328
GSE53622 SAFB 6294 6524 0.4768 0.0000
GSE53624 SAFB 6294 6524 0.5892 0.0000
GSE63941 SAFB 6294 201748_s_at 0.1517 0.4249
GSE77861 SAFB 6294 201748_s_at 0.4958 0.0221
GSE97050 SAFB 6294 A_33_P3220818 0.1021 0.6212
SRP007169 SAFB 6294 RNAseq 1.4763 0.0152
SRP008496 SAFB 6294 RNAseq 1.6582 0.0005
SRP064894 SAFB 6294 RNAseq 0.4396 0.0006
SRP133303 SAFB 6294 RNAseq 0.2106 0.1156
SRP159526 SAFB 6294 RNAseq 0.3475 0.0358
SRP193095 SAFB 6294 RNAseq 0.2976 0.0292
SRP219564 SAFB 6294 RNAseq 0.2701 0.2617
TCGA SAFB 6294 RNAseq 0.0847 0.0659

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SAFB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SAFB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SAFB 6294 5 3 22
GSE20123 SAFB 6294 4 2 24
GSE43470 SAFB 6294 2 6 35
GSE46452 SAFB 6294 47 1 11
GSE47630 SAFB 6294 5 7 28
GSE54993 SAFB 6294 16 3 51
GSE54994 SAFB 6294 6 16 31
GSE60625 SAFB 6294 9 0 2
GSE74703 SAFB 6294 2 4 30
GSE74704 SAFB 6294 1 2 17
TCGA SAFB 6294 10 18 68

Total number of gains: 107; Total number of losses: 62; Total Number of normals: 319.  

 

Somatic mutations of SAFB:

 

Generating mutation plots.

 

Highly correlated genes for SAFB:

 

Showing top 20/562 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SAFBPDCD2L0.715077404
SAFBUBE2T0.6957505
SAFBIPO90.683773706
SAFBFBRSL10.682045403
SAFBLONP10.6670541009
SAFBCKS1B0.666087808
SAFBNUP620.665336908
SAFBRNASEH2A0.662357807
SAFBMCM40.660076707
SAFBHDGF0.656596908
SAFBSLC5A60.655844706
SAFBDESI20.653661808
SAFBNEURL40.652292404
SAFBERCC30.65107908
SAFBYDJC0.650987504
SAFBRUVBL10.647843808
SAFBTAF50.646501908
SAFBMEGF80.646202404
SAFBCENPF0.646045807
SAFBAURKB0.645392807

For details and further investigation, click here