| Full name: STEAP3 metalloreductase | Alias Symbol: TSAP6|dudlin-2|STMP3 | ||
| Type: protein-coding gene | Cytoband: 2q14.2 | ||
| Entrez ID: 55240 | HGNC ID: HGNC:24592 | Ensembl Gene: ENSG00000115107 | OMIM ID: 609671 |
| Drug and gene relationship at DGIdb | |||
STEAP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of STEAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STEAP3 | 55240 | 218424_s_at | 1.2113 | 0.1452 | |
| GSE20347 | STEAP3 | 55240 | 218424_s_at | 0.4151 | 0.0500 | |
| GSE23400 | STEAP3 | 55240 | 218424_s_at | 0.2094 | 0.0134 | |
| GSE26886 | STEAP3 | 55240 | 218424_s_at | 0.5600 | 0.0063 | |
| GSE29001 | STEAP3 | 55240 | 218424_s_at | -0.0415 | 0.9069 | |
| GSE38129 | STEAP3 | 55240 | 218424_s_at | 0.8372 | 0.0002 | |
| GSE45670 | STEAP3 | 55240 | 218424_s_at | 0.6288 | 0.0006 | |
| GSE53622 | STEAP3 | 55240 | 141883 | 0.3539 | 0.0000 | |
| GSE53624 | STEAP3 | 55240 | 141883 | 0.4128 | 0.0000 | |
| GSE63941 | STEAP3 | 55240 | 218424_s_at | -0.5724 | 0.4395 | |
| GSE77861 | STEAP3 | 55240 | 218424_s_at | -0.0296 | 0.9068 | |
| GSE97050 | STEAP3 | 55240 | A_23_P90601 | 0.5934 | 0.1512 | |
| SRP007169 | STEAP3 | 55240 | RNAseq | 0.3186 | 0.6544 | |
| SRP008496 | STEAP3 | 55240 | RNAseq | 1.0622 | 0.0281 | |
| SRP064894 | STEAP3 | 55240 | RNAseq | 0.4311 | 0.1074 | |
| SRP133303 | STEAP3 | 55240 | RNAseq | 0.5858 | 0.0879 | |
| SRP159526 | STEAP3 | 55240 | RNAseq | -0.0854 | 0.8379 | |
| SRP193095 | STEAP3 | 55240 | RNAseq | 0.1532 | 0.2712 | |
| SRP219564 | STEAP3 | 55240 | RNAseq | 0.7834 | 0.1218 | |
| TCGA | STEAP3 | 55240 | RNAseq | -0.0631 | 0.4840 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by STEAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STEAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STEAP3 | 55240 | 6 | 1 | 23 | |
| GSE20123 | STEAP3 | 55240 | 6 | 1 | 23 | |
| GSE43470 | STEAP3 | 55240 | 3 | 1 | 39 | |
| GSE46452 | STEAP3 | 55240 | 1 | 4 | 54 | |
| GSE47630 | STEAP3 | 55240 | 6 | 0 | 34 | |
| GSE54993 | STEAP3 | 55240 | 0 | 6 | 64 | |
| GSE54994 | STEAP3 | 55240 | 11 | 0 | 42 | |
| GSE60625 | STEAP3 | 55240 | 0 | 3 | 8 | |
| GSE74703 | STEAP3 | 55240 | 3 | 1 | 32 | |
| GSE74704 | STEAP3 | 55240 | 3 | 1 | 16 | |
| TCGA | STEAP3 | 55240 | 32 | 6 | 58 |
Total number of gains: 71; Total number of losses: 24; Total Number of normals: 393.
Somatic mutations of STEAP3:
Generating mutation plots.
Highly correlated genes for STEAP3:
Showing top 20/246 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STEAP3 | PODXL2 | 0.745258 | 3 | 0 | 3 |
| STEAP3 | POLR1A | 0.711874 | 3 | 0 | 3 |
| STEAP3 | MIIP | 0.68459 | 3 | 0 | 3 |
| STEAP3 | FOXJ1 | 0.678811 | 3 | 0 | 3 |
| STEAP3 | NSUN6 | 0.6634 | 3 | 0 | 3 |
| STEAP3 | HDAC8 | 0.657994 | 3 | 0 | 3 |
| STEAP3 | F11R | 0.652608 | 6 | 0 | 4 |
| STEAP3 | FBRSL1 | 0.647268 | 4 | 0 | 4 |
| STEAP3 | LRFN1 | 0.641243 | 3 | 0 | 3 |
| STEAP3 | SUV39H2 | 0.638138 | 4 | 0 | 3 |
| STEAP3 | IGSF9 | 0.637202 | 5 | 0 | 4 |
| STEAP3 | TRIM11 | 0.635698 | 5 | 0 | 3 |
| STEAP3 | CPAMD8 | 0.632911 | 3 | 0 | 3 |
| STEAP3 | FAM53A | 0.632578 | 3 | 0 | 3 |
| STEAP3 | DEPDC1B | 0.631589 | 4 | 0 | 3 |
| STEAP3 | HOXC9 | 0.629037 | 4 | 0 | 3 |
| STEAP3 | SLC5A6 | 0.626645 | 7 | 0 | 5 |
| STEAP3 | WDR53 | 0.624419 | 5 | 0 | 4 |
| STEAP3 | SIGIRR | 0.619206 | 3 | 0 | 3 |
| STEAP3 | KIF18B | 0.61321 | 6 | 0 | 5 |
For details and further investigation, click here
