CDC7

 

Full name: cell division cycle 7 Alias Symbol: Hsk1|huCdc7|HsCdc7
Type: protein-coding gene Cytoband: 1p22.1
Entrez ID: 8317 HGNC ID: HGNC:1745 Ensembl Gene: ENSG00000097046 OMIM ID: 603311
Drug and gene relationship at DGIdb

 

CDC7 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of CDC7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDC7 8317 204510_at 1.1884 0.0409
GSE20347 CDC7 8317 204510_at 0.8943 0.0002
GSE23400 CDC7 8317 204510_at 0.8161 0.0000
GSE26886 CDC7 8317 204510_at 0.5801 0.1163
GSE29001 CDC7 8317 204510_at 1.2297 0.0012
GSE38129 CDC7 8317 204510_at 1.2669 0.0000
GSE45670 CDC7 8317 204510_at 0.6691 0.0049
GSE53622 CDC7 8317 13817 0.8816 0.0000
GSE53624 CDC7 8317 13817 1.0884 0.0000
GSE63941 CDC7 8317 204510_at 2.4539 0.0012
GSE77861 CDC7 8317 204510_at 0.5667 0.1793
GSE97050 CDC7 8317 A_23_P148807 0.3489 0.3571
SRP007169 CDC7 8317 RNAseq 1.3304 0.0090
SRP008496 CDC7 8317 RNAseq 1.4666 0.0000
SRP064894 CDC7 8317 RNAseq 1.2496 0.0001
SRP133303 CDC7 8317 RNAseq 1.1200 0.0000
SRP159526 CDC7 8317 RNAseq 0.5544 0.1599
SRP193095 CDC7 8317 RNAseq 0.7561 0.0001
SRP219564 CDC7 8317 RNAseq 1.2954 0.0367
TCGA CDC7 8317 RNAseq 0.7601 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by CDC7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDC7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDC7 8317 0 8 22
GSE20123 CDC7 8317 0 8 22
GSE43470 CDC7 8317 2 5 36
GSE46452 CDC7 8317 1 1 57
GSE47630 CDC7 8317 8 5 27
GSE54993 CDC7 8317 0 1 69
GSE54994 CDC7 8317 6 2 45
GSE60625 CDC7 8317 0 0 11
GSE74703 CDC7 8317 1 4 31
GSE74704 CDC7 8317 0 5 15
TCGA CDC7 8317 6 24 66

Total number of gains: 24; Total number of losses: 63; Total Number of normals: 401.  

 

Somatic mutations of CDC7:

 

Generating mutation plots.

 

Highly correlated genes for CDC7:

 

Showing top 20/1138 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDC7KIF2C0.77667913012
CDC7CDK10.7748212012
CDC7RAD51AP10.76895213012
CDC7KIF18B0.76637311011
CDC7MCM60.76489712012
CDC7CENPF0.75448713012
CDC7CCNA20.75052212012
CDC7TRIP130.75000312012
CDC7UHRF10.744313909
CDC7STIL0.74380913013
CDC7MCM30.74091911011
CDC7ECT20.73758713013
CDC7MAD2L10.73707812012
CDC7DTL0.73619113011
CDC7CDC200.73334112012
CDC7BUB1B0.73215511010
CDC7NCAPH0.731382909
CDC7NEK20.73013313013
CDC7TPX20.72927112012
CDC7ASPM0.72816513012

For details and further investigation, click here