| Full name: taste 1 receptor member 2 | Alias Symbol: T1R2|TR2 | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 80834 | HGNC ID: HGNC:14905 | Ensembl Gene: ENSG00000179002 | OMIM ID: 606226 |
| Drug and gene relationship at DGIdb | |||
TAS1R2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction | |
| hsa04973 | Carbohydrate digestion and absorption |
Expression of TAS1R2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAS1R2 | 80834 | 1553529_at | -0.1653 | 0.4456 | |
| GSE26886 | TAS1R2 | 80834 | 1553529_at | -0.2294 | 0.0188 | |
| GSE45670 | TAS1R2 | 80834 | 1553529_at | 0.0324 | 0.7112 | |
| GSE63941 | TAS1R2 | 80834 | 1553529_at | -0.0078 | 0.9566 | |
| GSE77861 | TAS1R2 | 80834 | 1553529_at | -0.0765 | 0.4060 | |
| TCGA | TAS1R2 | 80834 | RNAseq | 1.0342 | 0.3723 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TAS1R2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TAS1R2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAS1R2 | 80834 | 0 | 5 | 25 | |
| GSE20123 | TAS1R2 | 80834 | 0 | 4 | 26 | |
| GSE43470 | TAS1R2 | 80834 | 0 | 8 | 35 | |
| GSE46452 | TAS1R2 | 80834 | 5 | 1 | 53 | |
| GSE47630 | TAS1R2 | 80834 | 8 | 3 | 29 | |
| GSE54993 | TAS1R2 | 80834 | 3 | 1 | 66 | |
| GSE54994 | TAS1R2 | 80834 | 11 | 4 | 38 | |
| GSE60625 | TAS1R2 | 80834 | 0 | 0 | 11 | |
| GSE74703 | TAS1R2 | 80834 | 0 | 5 | 31 | |
| GSE74704 | TAS1R2 | 80834 | 0 | 0 | 20 | |
| TCGA | TAS1R2 | 80834 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of TAS1R2:
Generating mutation plots.
Highly correlated genes for TAS1R2:
Showing top 20/21 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAS1R2 | UNC13D | 0.672128 | 3 | 0 | 3 |
| TAS1R2 | NDOR1 | 0.658386 | 3 | 0 | 3 |
| TAS1R2 | KRT72 | 0.626431 | 3 | 0 | 3 |
| TAS1R2 | MYOZ1 | 0.603008 | 3 | 0 | 3 |
| TAS1R2 | TOM1L2 | 0.59653 | 3 | 0 | 3 |
| TAS1R2 | C2orf16 | 0.588694 | 3 | 0 | 3 |
| TAS1R2 | ZNF365 | 0.581834 | 3 | 0 | 3 |
| TAS1R2 | CYP2A6 | 0.581055 | 3 | 0 | 3 |
| TAS1R2 | TSHB | 0.58058 | 3 | 0 | 3 |
| TAS1R2 | EVPL | 0.576183 | 3 | 0 | 3 |
| TAS1R2 | RECQL5 | 0.566633 | 3 | 0 | 3 |
| TAS1R2 | MAT1A | 0.562294 | 3 | 0 | 3 |
| TAS1R2 | NODAL | 0.551111 | 4 | 0 | 3 |
| TAS1R2 | PSG6 | 0.550807 | 4 | 0 | 3 |
| TAS1R2 | EVPLL | 0.550039 | 3 | 0 | 3 |
| TAS1R2 | CARD14 | 0.546461 | 3 | 0 | 3 |
| TAS1R2 | OSTF1 | 0.535809 | 3 | 0 | 3 |
| TAS1R2 | NLRX1 | 0.522237 | 3 | 0 | 3 |
| TAS1R2 | SAMD10 | 0.521599 | 4 | 0 | 3 |
| TAS1R2 | KALRN | 0.51231 | 3 | 0 | 3 |
For details and further investigation, click here
