| Full name: ubiquitin like modifier activating enzyme 5 | Alias Symbol: FLJ23251 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 79876 | HGNC ID: HGNC:23230 | Ensembl Gene: ENSG00000081307 | OMIM ID: 610552 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBA5 | 79876 | 218289_s_at | 0.0293 | 0.9437 | |
| GSE20347 | UBA5 | 79876 | 218289_s_at | 0.3862 | 0.0084 | |
| GSE23400 | UBA5 | 79876 | 218289_s_at | 0.2451 | 0.0000 | |
| GSE26886 | UBA5 | 79876 | 222579_at | 0.0133 | 0.9640 | |
| GSE29001 | UBA5 | 79876 | 218289_s_at | 0.4539 | 0.1522 | |
| GSE38129 | UBA5 | 79876 | 218289_s_at | 0.3011 | 0.0050 | |
| GSE45670 | UBA5 | 79876 | 222578_s_at | 0.2390 | 0.0437 | |
| GSE53622 | UBA5 | 79876 | 43621 | -0.0490 | 0.6266 | |
| GSE53624 | UBA5 | 79876 | 43621 | 0.2034 | 0.0371 | |
| GSE63941 | UBA5 | 79876 | 218289_s_at | -0.2557 | 0.5677 | |
| GSE77861 | UBA5 | 79876 | 222578_s_at | 0.4418 | 0.2150 | |
| GSE97050 | UBA5 | 79876 | A_33_P3365652 | 0.1154 | 0.5763 | |
| SRP007169 | UBA5 | 79876 | RNAseq | 0.6197 | 0.0547 | |
| SRP008496 | UBA5 | 79876 | RNAseq | 0.7799 | 0.0002 | |
| SRP064894 | UBA5 | 79876 | RNAseq | 0.3573 | 0.0095 | |
| SRP133303 | UBA5 | 79876 | RNAseq | 0.3870 | 0.0282 | |
| SRP159526 | UBA5 | 79876 | RNAseq | 0.5015 | 0.0393 | |
| SRP193095 | UBA5 | 79876 | RNAseq | 0.1043 | 0.2127 | |
| SRP219564 | UBA5 | 79876 | RNAseq | 0.2967 | 0.2111 | |
| TCGA | UBA5 | 79876 | RNAseq | -0.1012 | 0.0504 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBA5 | 79876 | 16 | 0 | 14 | |
| GSE20123 | UBA5 | 79876 | 16 | 0 | 14 | |
| GSE43470 | UBA5 | 79876 | 21 | 0 | 22 | |
| GSE46452 | UBA5 | 79876 | 15 | 4 | 40 | |
| GSE47630 | UBA5 | 79876 | 18 | 3 | 19 | |
| GSE54993 | UBA5 | 79876 | 2 | 8 | 60 | |
| GSE54994 | UBA5 | 79876 | 32 | 3 | 18 | |
| GSE60625 | UBA5 | 79876 | 0 | 6 | 5 | |
| GSE74703 | UBA5 | 79876 | 18 | 0 | 18 | |
| GSE74704 | UBA5 | 79876 | 11 | 0 | 9 | |
| TCGA | UBA5 | 79876 | 58 | 6 | 32 |
Total number of gains: 207; Total number of losses: 30; Total Number of normals: 251.
Somatic mutations of UBA5:
Generating mutation plots.
Highly correlated genes for UBA5:
Showing top 20/302 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBA5 | C16orf74 | 0.711367 | 3 | 0 | 3 |
| UBA5 | ERLIN2 | 0.645592 | 4 | 0 | 3 |
| UBA5 | NAA50 | 0.638233 | 7 | 0 | 6 |
| UBA5 | GEMIN2 | 0.632 | 4 | 0 | 4 |
| UBA5 | LRRC58 | 0.627703 | 4 | 0 | 3 |
| UBA5 | ZNF658 | 0.623112 | 4 | 0 | 3 |
| UBA5 | TTC39C | 0.617227 | 3 | 0 | 3 |
| UBA5 | ABHD10 | 0.617198 | 9 | 0 | 8 |
| UBA5 | SKA3 | 0.614904 | 3 | 0 | 3 |
| UBA5 | UMPS | 0.61476 | 9 | 0 | 8 |
| UBA5 | COPB2 | 0.61449 | 10 | 0 | 9 |
| UBA5 | CDC73 | 0.608774 | 4 | 0 | 3 |
| UBA5 | BRAP | 0.60715 | 4 | 0 | 3 |
| UBA5 | CNBP | 0.606382 | 10 | 0 | 8 |
| UBA5 | DNAJC19 | 0.60377 | 6 | 0 | 5 |
| UBA5 | ZNF35 | 0.603029 | 4 | 0 | 3 |
| UBA5 | TBCCD1 | 0.59644 | 8 | 0 | 6 |
| UBA5 | TRIM59 | 0.596369 | 5 | 0 | 4 |
| UBA5 | COMMD2 | 0.595639 | 7 | 0 | 5 |
| UBA5 | SEC22A | 0.593079 | 10 | 0 | 8 |
For details and further investigation, click here
