USP18

 

Full name: ubiquitin specific peptidase 18 Alias Symbol: 
Type: protein-coding gene Cytoband: 22q11.2
Entrez ID: 11274 HGNC ID: HGNC:12616 Ensembl Gene: ENSG00000184979 OMIM ID: 607057
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of USP18:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 USP18 11274 219211_at 0.6207 0.3760
GSE20347 USP18 11274 219211_at 0.8657 0.0037
GSE23400 USP18 11274 219211_at 0.6108 0.0000
GSE26886 USP18 11274 219211_at 0.9782 0.0002
GSE29001 USP18 11274 219211_at 1.6029 0.0004
GSE38129 USP18 11274 219211_at 0.9306 0.0000
GSE45670 USP18 11274 219211_at 1.5860 0.0000
GSE53622 USP18 11274 84934 1.4381 0.0000
GSE53624 USP18 11274 84934 1.6232 0.0000
GSE63941 USP18 11274 219211_at 0.5607 0.4087
GSE77861 USP18 11274 219211_at 0.3050 0.1869
GSE97050 USP18 11274 A_23_P132159 0.5414 0.4019
SRP007169 USP18 11274 RNAseq 2.0275 0.0014
SRP008496 USP18 11274 RNAseq 2.0074 0.0006
SRP064894 USP18 11274 RNAseq 2.4591 0.0000
SRP133303 USP18 11274 RNAseq 1.3957 0.0000
SRP159526 USP18 11274 RNAseq 1.1232 0.0042
SRP193095 USP18 11274 RNAseq 1.2611 0.0000
SRP219564 USP18 11274 RNAseq 2.0682 0.0136
TCGA USP18 11274 RNAseq 0.6637 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by USP18 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of USP18:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 USP18 11274 4 7 19
GSE20123 USP18 11274 4 7 19
GSE43470 USP18 11274 5 7 31
GSE46452 USP18 11274 32 2 25
GSE47630 USP18 11274 8 5 27
GSE54993 USP18 11274 3 6 61
GSE54994 USP18 11274 12 7 34
GSE60625 USP18 11274 5 0 6
GSE74703 USP18 11274 5 5 26
GSE74704 USP18 11274 2 4 14
TCGA USP18 11274 27 17 52

Total number of gains: 107; Total number of losses: 67; Total Number of normals: 314.  

 

Somatic mutations of USP18:

 

Generating mutation plots.

 

Highly correlated genes for USP18:

 

Showing top 20/1332 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
USP18USP410.910143303
USP18RNF2130.754332403
USP18ANKRD230.750354303
USP18CMPK20.750045807
USP18SSBP40.749934303
USP18PARP140.746894909
USP18IFI60.74519312012
USP18IFI44L0.74141312012
USP18IFI350.74074413013
USP18ARHGAP90.727117303
USP18SLC39A30.719378404
USP18EPSTI10.712388706
USP18DDX600.71199413013
USP18RSAD20.71113412011
USP18IFIT30.7095312012
USP18LAMP30.70943212011
USP18PARP120.7086113012
USP18HERC50.70842813012
USP18EIF2AK20.70532313012
USP18IFI440.704913011

For details and further investigation, click here