| Full name: V-set domain containing T cell activation inhibitor 1 | Alias Symbol: B7-H4|FLJ22418|B7S1|B7x|B7H4 | ||
| Type: protein-coding gene | Cytoband: 1p13.1-p12 | ||
| Entrez ID: 79679 | HGNC ID: HGNC:28873 | Ensembl Gene: ENSG00000134258 | OMIM ID: 608162 |
| Drug and gene relationship at DGIdb | |||
Expression of VTCN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VTCN1 | 79679 | 219768_at | -0.0402 | 0.9728 | |
| GSE20347 | VTCN1 | 79679 | 219768_at | 0.6572 | 0.0130 | |
| GSE23400 | VTCN1 | 79679 | 219768_at | 0.1149 | 0.0552 | |
| GSE26886 | VTCN1 | 79679 | 219768_at | 0.9878 | 0.0327 | |
| GSE29001 | VTCN1 | 79679 | 219768_at | 0.3576 | 0.3725 | |
| GSE38129 | VTCN1 | 79679 | 219768_at | 0.6633 | 0.0017 | |
| GSE45670 | VTCN1 | 79679 | 219768_at | 0.7815 | 0.1892 | |
| GSE53622 | VTCN1 | 79679 | 11585 | 0.7977 | 0.0064 | |
| GSE53624 | VTCN1 | 79679 | 11585 | 0.7569 | 0.0106 | |
| GSE63941 | VTCN1 | 79679 | 219768_at | 2.7323 | 0.0873 | |
| GSE77861 | VTCN1 | 79679 | 219768_at | 0.4226 | 0.3919 | |
| GSE97050 | VTCN1 | 79679 | A_23_P518 | 0.2875 | 0.3199 | |
| SRP133303 | VTCN1 | 79679 | RNAseq | -0.1203 | 0.8603 | |
| SRP159526 | VTCN1 | 79679 | RNAseq | 2.3639 | 0.0391 | |
| SRP219564 | VTCN1 | 79679 | RNAseq | 1.9546 | 0.0574 | |
| TCGA | VTCN1 | 79679 | RNAseq | 0.8389 | 0.1100 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by VTCN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VTCN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VTCN1 | 79679 | 0 | 8 | 22 | |
| GSE20123 | VTCN1 | 79679 | 0 | 8 | 22 | |
| GSE43470 | VTCN1 | 79679 | 0 | 5 | 38 | |
| GSE46452 | VTCN1 | 79679 | 2 | 1 | 56 | |
| GSE47630 | VTCN1 | 79679 | 9 | 5 | 26 | |
| GSE54993 | VTCN1 | 79679 | 0 | 1 | 69 | |
| GSE54994 | VTCN1 | 79679 | 10 | 2 | 41 | |
| GSE60625 | VTCN1 | 79679 | 0 | 0 | 11 | |
| GSE74703 | VTCN1 | 79679 | 0 | 4 | 32 | |
| GSE74704 | VTCN1 | 79679 | 0 | 4 | 16 | |
| TCGA | VTCN1 | 79679 | 15 | 28 | 53 |
Total number of gains: 36; Total number of losses: 66; Total Number of normals: 386.
Somatic mutations of VTCN1:
Generating mutation plots.
Highly correlated genes for VTCN1:
Showing top 20/77 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VTCN1 | STAG3 | 0.729451 | 3 | 0 | 3 |
| VTCN1 | SULT1E1 | 0.680009 | 4 | 0 | 3 |
| VTCN1 | MRAP2 | 0.662826 | 5 | 0 | 3 |
| VTCN1 | FAXC | 0.662445 | 4 | 0 | 3 |
| VTCN1 | PROM1 | 0.659113 | 3 | 0 | 3 |
| VTCN1 | IQCA1 | 0.628114 | 3 | 0 | 3 |
| VTCN1 | STRA6 | 0.626618 | 3 | 0 | 3 |
| VTCN1 | SLC4A11 | 0.611426 | 4 | 0 | 3 |
| VTCN1 | WFDC2 | 0.608421 | 7 | 0 | 5 |
| VTCN1 | CCDC57 | 0.607971 | 5 | 0 | 3 |
| VTCN1 | ZNF711 | 0.605179 | 3 | 0 | 3 |
| VTCN1 | MMP20 | 0.600734 | 3 | 0 | 3 |
| VTCN1 | ZNF670 | 0.599795 | 3 | 0 | 3 |
| VTCN1 | MIEN1 | 0.598018 | 3 | 0 | 3 |
| VTCN1 | SAMD12 | 0.594483 | 3 | 0 | 3 |
| VTCN1 | AOAH | 0.593449 | 3 | 0 | 3 |
| VTCN1 | KCNN4 | 0.58927 | 6 | 0 | 4 |
| VTCN1 | ATP8A2 | 0.588789 | 3 | 0 | 3 |
| VTCN1 | RARRES1 | 0.588535 | 5 | 0 | 3 |
| VTCN1 | CLDN3 | 0.585816 | 6 | 0 | 4 |
For details and further investigation, click here
