| Full name: WD repeat containing antisense to TP53 | Alias Symbol: FLJ10385|TCAB1 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 55135 | HGNC ID: HGNC:25522 | Ensembl Gene: ENSG00000141499 | OMIM ID: 612661 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WRAP53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WRAP53 | 55135 | 44563_at | 0.6302 | 0.0132 | |
| GSE20347 | WRAP53 | 55135 | 44563_at | 0.4583 | 0.0001 | |
| GSE23400 | WRAP53 | 55135 | 44563_at | 0.1408 | 0.0021 | |
| GSE26886 | WRAP53 | 55135 | 44563_at | 0.6062 | 0.0001 | |
| GSE29001 | WRAP53 | 55135 | 44563_at | 0.1237 | 0.4847 | |
| GSE38129 | WRAP53 | 55135 | 44563_at | 0.4522 | 0.0000 | |
| GSE45670 | WRAP53 | 55135 | 44563_at | 0.4856 | 0.0001 | |
| GSE53622 | WRAP53 | 55135 | 27301 | -0.5914 | 0.0000 | |
| GSE53624 | WRAP53 | 55135 | 27301 | -1.7927 | 0.0000 | |
| GSE63941 | WRAP53 | 55135 | 44563_at | 0.8643 | 0.0024 | |
| GSE77861 | WRAP53 | 55135 | 44563_at | 0.1774 | 0.1116 | |
| GSE97050 | WRAP53 | 55135 | A_23_P55064 | 0.1577 | 0.5286 | |
| SRP007169 | WRAP53 | 55135 | RNAseq | 1.3682 | 0.0092 | |
| SRP008496 | WRAP53 | 55135 | RNAseq | 1.3371 | 0.0014 | |
| SRP064894 | WRAP53 | 55135 | RNAseq | 1.3785 | 0.0000 | |
| SRP133303 | WRAP53 | 55135 | RNAseq | 0.6638 | 0.0017 | |
| SRP159526 | WRAP53 | 55135 | RNAseq | 1.2409 | 0.0001 | |
| SRP193095 | WRAP53 | 55135 | RNAseq | 0.7858 | 0.0000 | |
| SRP219564 | WRAP53 | 55135 | RNAseq | 1.4462 | 0.0009 | |
| TCGA | WRAP53 | 55135 | RNAseq | 0.3636 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by WRAP53 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WRAP53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WRAP53 | 55135 | 4 | 2 | 24 | |
| GSE20123 | WRAP53 | 55135 | 4 | 3 | 23 | |
| GSE43470 | WRAP53 | 55135 | 1 | 6 | 36 | |
| GSE46452 | WRAP53 | 55135 | 34 | 1 | 24 | |
| GSE47630 | WRAP53 | 55135 | 7 | 1 | 32 | |
| GSE54993 | WRAP53 | 55135 | 4 | 3 | 63 | |
| GSE54994 | WRAP53 | 55135 | 5 | 8 | 40 | |
| GSE60625 | WRAP53 | 55135 | 4 | 0 | 7 | |
| GSE74703 | WRAP53 | 55135 | 1 | 3 | 32 | |
| GSE74704 | WRAP53 | 55135 | 2 | 1 | 17 | |
| TCGA | WRAP53 | 55135 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of WRAP53:
Generating mutation plots.
Highly correlated genes for WRAP53:
Showing top 20/331 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WRAP53 | RIMS4 | 0.7528 | 3 | 0 | 3 |
| WRAP53 | SLX4 | 0.736044 | 3 | 0 | 3 |
| WRAP53 | TNFAIP8L1 | 0.734695 | 6 | 0 | 6 |
| WRAP53 | AGAP2-AS1 | 0.713766 | 4 | 0 | 4 |
| WRAP53 | STMN3 | 0.706556 | 3 | 0 | 3 |
| WRAP53 | FANCD2 | 0.704504 | 3 | 0 | 3 |
| WRAP53 | PKMYT1 | 0.701124 | 9 | 0 | 8 |
| WRAP53 | CCDC114 | 0.693188 | 3 | 0 | 3 |
| WRAP53 | NPW | 0.691999 | 4 | 0 | 4 |
| WRAP53 | CDC6 | 0.675864 | 8 | 0 | 7 |
| WRAP53 | MEI1 | 0.6715 | 3 | 0 | 3 |
| WRAP53 | LRRC45 | 0.665996 | 4 | 0 | 4 |
| WRAP53 | FAM163B | 0.665275 | 3 | 0 | 3 |
| WRAP53 | MTFP1 | 0.660638 | 5 | 0 | 5 |
| WRAP53 | SPRR2G | 0.652413 | 3 | 0 | 3 |
| WRAP53 | HOXA10 | 0.652033 | 8 | 0 | 8 |
| WRAP53 | SUPT6H | 0.651249 | 4 | 0 | 4 |
| WRAP53 | ABCC10 | 0.647736 | 4 | 0 | 3 |
| WRAP53 | MEX3D | 0.647443 | 4 | 0 | 3 |
| WRAP53 | KLHL26 | 0.645144 | 4 | 0 | 3 |
For details and further investigation, click here
